Wigraine

Vascular Headaches, Postpartum state, Cluster Headache + 2 more
Treatment
3 FDA approvals
20 Active Studies for Wigraine

What is Wigraine

ErgotamineThe Generic name of this drug
Treatment SummaryCaffeine is a drug used for various medical purposes. It is similar in structure to Theophylline and Theobromine and can be found in coffee beans, tea, and cacao beans. It is also used in some cosmetic products and can be taken orally, by inhalation, topically, or by injection. Caffeine injection is approved by the FDA and is used to treat apnea of the premature newborn and improve the quality of life of these babies.
Cafergotis the brand name
image of different drug pills on a surface
Wigraine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Cafergot
Ergotamine
1953
15

Approved as Treatment by the FDA

Ergotamine, also known as Cafergot, is approved by the FDA for 3 uses which include Cluster Headache and Vascular Headaches .
Cluster Headache
Vascular Headaches
Used to treat Vascular Headaches in combination with Caffeine
Migraine

Effectiveness

How Wigraine Affects PatientsCaffeine wakes up the brain and body, helping you feel more alert and energized. It can also make you feel jittery and restless. Caffeine helps with digestion by increasing stomach acid and helping food move through the digestive system. Caffeine is often combined with painkillers to help relieve migraine and other types of headaches. Lastly, caffeine can make you have to urinate more often.
How Wigraine works in the bodyCaffeine affects many different parts of the body. It can stop some enzymes from working, block certain receptors, change the way cells handle calcium, and stop adenosine receptors from working. In the respiratory system, caffeine increases response to carbon dioxide and stimulates breathing. In the central nervous system, caffeine boosts alertness by blocking adenosine receptors. In the renal system, it causes more urination by stimulating renal blood flow. In the cardiovascular system, caffeine causes blood vessels to relax and increases heart rate. It also helps with headaches by constricting blood vessels in the brain.

When to interrupt dosage

The proposed dosage of Wigraine is determined by the identified condition, for example Overdose, Drug, Catarrh and Athletic Performance. The amount likewise fluctuates as per the delivery system (e.g. Tablet or Tablet - Oral) noted in the table beneath.
Condition
Dosage
Administration
Cluster Headache
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Migraine
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Postpartum state
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Uterine Atony
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral
Vascular Headaches
1.0 mg, , 2.0 mg, 0.6 mg, 0.3 mg, 9.0 mg/mL
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Rectal, Suppository, Suppository - Rectal, Sublingual, Tablet, orally disintegrating, Tablet, orally disintegrating - Sublingual, Tablet - Sublingual, Capsule, Capsule - Oral, Tablet, extended release, Tablet, extended release - Oral, Aerosol, Aerosol - Oral

Warnings

Wigraine has one contraindication that should be taken into consideration. If you have any of the conditions listed in the table below, Wigraine should not be consumed.Wigraine Contraindications
Condition
Risk Level
Notes
Impaired Hepatic Function
Do Not Combine
Impaired Renal Function
Do Not Combine
Coronary Heart Disease
Do Not Combine
Peripheral Vascular Disease
Do Not Combine
Pulse Frequency
Do Not Combine
Hypertensive disease
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Wigraine.
Common Wigraine Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Major
The metabolism of (R)-warfarin can be decreased when combined with Ergotamine.
(S)-Warfarin
Major
The metabolism of (S)-Warfarin can be decreased when combined with Ergotamine.
1,2-Benzodiazepine
Major
The metabolism of 1,2-Benzodiazepine can be decreased when combined with Ergotamine.
3,5-diiodothyropropionic acid
Major
The metabolism of 3,5-diiodothyropropionic acid can be decreased when combined with Ergotamine.
4-Bromo-2,5-dimethoxyphenethylamine
Major
Ergotamine may increase the hypertensive and vasoconstricting activities of 4-Bromo-2,5-dimethoxyphenethylamine.
Wigraine Toxicity & Overdose RiskThe toxic dose of caffeine for rats is about 192mg/kg. In humans, an overdose of caffeine can be deadly at a dose of 10-14 grams (150-200mg/kg of body weight). Symptoms of an overdose may include nausea, vomiting, diarrhea, restlessness, anxiety, insomnia, rapid heartbeat, and tremors. In some cases, death may occur. Treatment for a caffeine overdose includes offering symptomatic treatment for mild overdoses and intubation for severe cases. Activated charcoal and hemodialysis can prevent further complications. Benzodiazepine drugs can be used to prevent or treat seizures and IV fluids and

Wigraine Novel Uses: Which Conditions Have a Clinical Trial Featuring Wigraine?

A prodigious 429 active trials are currently underway to assess the potential of Wigraine in managing Chronic Fatigue Syndrome, Chronic Pain and Migraine Headaches.
Condition
Clinical Trials
Trial Phases
Postpartum state
5 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Cluster Headache
4 Actively Recruiting
Phase 1, Phase 3, Phase 2
Vascular Headaches
0 Actively Recruiting
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Uterine Atony
0 Actively Recruiting

Wigraine Reviews: What are patients saying about Wigraine?

5Patient Review
2/2/2012
Wigraine for Headache caused by Disorder of Cranial Blood Vessels
I've been using this treatment for 30 years to control my headaches, and it's been a real lifesaver.
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Patient Q&A Section about wigraine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Wigraine

Have you considered Wigraine clinical trials? We made a collection of clinical trials featuring Wigraine, we think they might fit your search criteria.
Have you considered Wigraine clinical trials? We made a collection of clinical trials featuring Wigraine, we think they might fit your search criteria.
Have you considered Wigraine clinical trials? We made a collection of clinical trials featuring Wigraine, we think they might fit your search criteria.
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