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What is Tranxene
Clorazepic acidThe Generic name of this drug
Treatment SummaryClorazepate is a medication used to treat anxiety and related symptoms. It has the added benefit of being able to relax muscles and prevent seizures.
Tranxene T-Tabis the brand name
Tranxene Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tranxene T-Tab
Clorazepic acid
1972
55
Approved as Treatment by the FDA
Clorazepic acid, otherwise called Tranxene T-Tab, is approved by the FDA for 4 uses which include Seizures and Acute Alcohol Withdrawal .Seizures
Acute Alcohol Withdrawal
Generalized Anxiety Disorder
Helps manage Generalized Anxiety Disorder
Anxiety
Effectiveness
How Tranxene Affects PatientsClorazepate is a type of medication in the benzodiazepine group. It has calming effects on the central nervous system and its main metabolite, nordiazepam, enters the bloodstream quickly. Research on healthy men shows that clorazepate has a calming effect on the central nervous system. When taken orally, clorazepate is changed into nordiazepam, meaning there is very little of the original drug left in the body.
How Tranxene works in the bodyBenzodiazepines work by binding to two receptors, BNZ1 and BNZ2. BNZ1 helps you sleep and BNZ2 helps to relax your muscles, prevent seizures, and improve coordination and memory. Benzodiazepines increase the effects of the neurotransmitter GABA, which stops cells from becoming overly excited. This stops cells from firing too much and helps you relax.
When to interrupt dosage
The proposed dose of Tranxene is contingent upon the determined condition, such as Seizures, Anxiety and Generalized Anxiety Disorder. The quantity of dosage varies, depending on the technique of delivery (e.g. Tablet - Oral or Capsule - Oral) detailed in the table below.Condition
Dosage
Administration
Generalized Anxiety Disorder
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Seizures
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Acute Alcohol Withdrawal
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Anxiety
, 3.75 mg, 7.5 mg, 15.0 mg, 11.3 mg, 5.0 mg, 22.5 mg
, Oral, Tablet - Oral, Tablet, Capsule, Capsule - Oral, Tablet, extended release - Oral, Tablet, extended release
Warnings
Tranxene has one contraindication and should not be taken while encountering any of the conditions displayed in the table below.Tranxene ContraindicationsCondition
Risk Level
Notes
Glaucoma
Do Not Combine
Common Tranxene Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Ethanol
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methadone
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Methadone.
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Clorazepic acid is combined with Oliceridine.
Sodium oxybate
Major
Clorazepic acid may increase the central nervous system depressant (CNS depressant) activities of Sodium oxybate.
Tranxene Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 1320mg/kg. Monkeys have also been found to tolerate a dose greater than 1600mg/kg. Overdosing on the drug can lead to confusion, coma, poor coordination, drowsiness, and a slower reaction time.
Tranxene Novel Uses: Which Conditions Have a Clinical Trial Featuring Tranxene?
32 active clinical trials are presently examining the potential of Tranxene to ameliorate Acute Alcohol Withdrawal, Anxiety and Seizure symptoms.Condition
Clinical Trials
Trial Phases
Seizures
2 Actively Recruiting
Phase 3
Generalized Anxiety Disorder
32 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4
Acute Alcohol Withdrawal
0 Actively Recruiting
Anxiety
0 Actively Recruiting
Tranxene Reviews: What are patients saying about Tranxene?
5Patient Review
5/15/2014 I've tried a lot of different medications for my anxiety and OCD, but none of them have worked as well as this one. Just 7.5 mg and I feel so much better with no side effects. I'm really grateful to have found something that finally works for me.
5Patient Review
2/18/2015 Though this medication is older, it's still just as effective. I think the price could be lower, though I understand the need for profit.
5Patient Review
8/11/2021 I've been taking anti-anxiety medications for 30 years now, and by far the most effective one I've found is Tranxene. It doesn't have any nasty side effects like some of the other ones I've tried, but it's hard to get because not many doctors prescribe it anymore.
5Patient Review
8/15/2014 This drug has been hugely helpful for my PTSD-anxiety. I've been on it for 20 years and have never needed to increase the dosage, which is amazing.
5Patient Review
12/2/2013 This treatment has been working well for me for over 30 years. I take it 2-3 times a day as needed.
5Patient Review
9/4/2012 I've been on tranxene for 35 years and it's the only medication I need. It really works well for me.
4.3Patient Review
9/7/2011 I was prescribed this for mild anxiety and to help lower blood pressure. However, after just a few days I began feeling very depressed. This was followed by days of crying for no reason. It took my son noticing the change before I realized it might be the medication. After discussing with my doctor, he said that while rare, some people do experience this side effect. So, I stopped taking the medication and have slowly returned to my "normal" anxious state.
3Patient Review
11/26/2019 My mother took this medication for almost a decade before she started showing signs of tardive dyskinesia and memory loss. It's been quite a nightmare since then.
2.3Patient Review
8/28/20111Patient Review
5/11/2017 I was disappointed with this medication. It didn't do much for my anxiety and it took too long to work. Xanax worked much better for me, and I took it for 18 years.
Patient Q&A Section about tranxene
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Tranxene used to treat?
"This medication is used to treat anxiety, acute alcohol withdrawal, and seizures. It belongs to a class of drugs called benzodiazepines which act on the brain and nerves (central nervous system) to produce a calming effect."
Answered by AI
Is Tranxene a narcotic?
"TRANXENE is a federally controlled substance (C-IV) because it has the potential to be abused or lead to dependence. Keep TRANXENE in a safe place to prevent misuse and abuse. Distributing TRANXENE, whether through selling or giving it away, can harm others and is against the law."
Answered by AI
Is Tranxene better than Xanax?
"Tranxene is considered to take effect more quickly, typically within 30-60 minutes, while Xanax is considered to have an intermediate onset range, which means it will typically take longer for the drug to take effect."
Answered by AI
How does Tranxene make you feel?
"Tranxene is a medication that affects the brain and central nervous system, creating a calming effect. The most common side effects are drowsiness, fatigue, dizziness, dry mouth, confusion, loss of coordination, and changes in mood."
Answered by AI