Tolvaptan

symptomatic euvolemic Hyponatremia, symptomatic hypervolemic Hyponatremia, Polycystic Kidney, Autosomal Dominant
Treatment
4 FDA approvals
8 Active Studies for Tolvaptan

What is Tolvaptan

TolvaptanThe Generic name of this drug
Treatment SummaryTolvaptan is used to treat low levels of sodium in the blood, a condition called hyponatremia, which can be caused by certain conditions including heart failure, cirrhosis, and SIADH. This medication was approved by the FDA in 2009.
Samscais the brand name
image of different drug pills on a surface
Tolvaptan Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Samsca
Tolvaptan
2009
20

Approved as Treatment by the FDA

Tolvaptan, also called Samsca, is approved by the FDA for 4 uses including Autosomal Dominant Polycystic Kidney Disease （ADPKD) and symptomatic euvolemic Hyponatremia .
Autosomal Dominant Polycystic Kidney Disease （ADPKD)
Helps manage Autosomal Dominant Polycystic Kidney Disease （ADPKD)
symptomatic euvolemic Hyponatremia
symptomatic hypervolemic Hyponatremia
Polycystic Kidney, Autosomal Dominant
Helps manage Autosomal Dominant Polycystic Kidney Disease （ADPKD)

Effectiveness

How Tolvaptan Affects PatientsTaking tolvaptan increases the amount of urine and fluids a person takes in, leading to an overall decrease in fluid levels. It can also raise sodium and osmolality levels in the blood, with bigger effects seen with higher doses. After 4-8 hours of taking tolvaptan, urine osmolality is reduced and more free water is cleared. This drug has a strong affinity for V2 receptors and does not affect V1a receptors.
How Tolvaptan works in the bodyTolvaptan is a drug that blocks the action of a hormone called vasopressin. This hormone helps to absorb water in the kidneys, and by blocking it, Tolvaptan increases urine volume and helps reduce the amount of water in the body. This can be especially helpful for heart failure patients, as they tend to have higher levels of vasopressin than other people.

When to interrupt dosage

The extent of Tolvaptan is dependent upon the declared circumstance, for instance symptomatic hypervolemic Hyponatremia, symptomatic euvolemic Hyponatremia and Polycystic Kidney, Autosomal Dominant. The measure of dosage fluctuates, conforming to the mode of administration provided in the table below.
Condition
Dosage
Administration
Polycystic Kidney, Autosomal Dominant
, 15.0 mg, 30.0 mg, 60.0 mg, 90.0 mg, 120.0 mg, 45.0 mg, 7.5 mg
Tablet - Oral, , Tablet, Oral
symptomatic euvolemic Hyponatremia
, 15.0 mg, 30.0 mg, 60.0 mg, 90.0 mg, 120.0 mg, 45.0 mg, 7.5 mg
Tablet - Oral, , Tablet, Oral
symptomatic hypervolemic Hyponatremia
, 15.0 mg, 30.0 mg, 60.0 mg, 90.0 mg, 120.0 mg, 45.0 mg, 7.5 mg
Tablet - Oral, , Tablet, Oral

Warnings

There are 20 known major drug interactions with Tolvaptan.
Common Tolvaptan Drug Interactions
Drug Name
Risk Level
Description
Desmopressin
Major
The therapeutic efficacy of Desmopressin can be decreased when used in combination with Tolvaptan.
Agmatine
Minor
The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Agmatine.
Aliskiren
Minor
The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Aliskiren.
Alminoprofen
Minor
The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Alminoprofen.
Anisodamine
Minor
The risk or severity of hyperkalemia can be increased when Tolvaptan is combined with Anisodamine.
Tolvaptan Toxicity & Overdose RiskThe lowest toxic dose of tolvaptan in rats and dogs has been found to be greater than 2000mg/kg. Common side effects of taking this drug include feeling thirsty, dry mouth, fatigue, constipation, frequent urination, and high blood sugar.
image of a doctor in a lab doing drug, clinical research

Tolvaptan Novel Uses: Which Conditions Have a Clinical Trial Featuring Tolvaptan?

Currently, 6 active studies are studying the potential of Tolvaptan in ameliorating symptoms of Euvolemic Hyponatremia, Polycystic Kidney Disease, Autosomal Dominant Polycystic Kidney Disease, and Hypervolemic Hyponatremia.
Condition
Clinical Trials
Trial Phases
Polycystic Kidney, Autosomal Dominant
8 Actively Recruiting
Phase 2, Not Applicable, Phase 3, Phase 1
symptomatic hypervolemic Hyponatremia
0 Actively Recruiting
symptomatic euvolemic Hyponatremia
0 Actively Recruiting

Tolvaptan Reviews: What are patients saying about Tolvaptan?

5Patient Review
10/3/2019
Tolvaptan for Autosomal Dominant Polycystic Kidney Disease
This medication has shown promising results so far. My GFR number has increased since starting this treatment, and my energy levels are better throughout the day. The only downside is that I have to drink a lot of water (I'm averaging 5-6 liters per day), and I have to urinate frequently (which can be disruptive if you're not near a restroom).
5Patient Review
6/15/2011
Tolvaptan for Low Amount of Sodium in the Blood
This medication is vital for my husband's survival, but our insurance company stopped covering it. They claim they sent us a letter, but we never received any notification. A thirty day supply costs almost nine thousand dollars out of pocket--we can't possibly afford that. If this is a result of the Affordable Care Act, it's terrible. Please help get rid of Obama and his policies!
5Patient Review
7/27/2012
Tolvaptan for Low Amount of Sodium in the Blood
This drug has been great for me. I have stage 4 small cell lung cancer and samsca sofar has kept my sodium level in the high 130's! hopefully my ins. will keep paying for it.
4.3Patient Review
11/23/2014
Tolvaptan for Syndrome of Inappropriate Antidiuretic Hormone Secretion
The only problem we had was with the cost. This medication helped my mom raise her chronically low sodium levels and also to drink fluids, but she didn't want to continue because insurance wouldn't cover it. It's very costly, but it does work.

Patient Q&A Section about tolvaptan

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What drug class is tolvaptan?

"Tolvaptan is a medication that causes the body to release water as urine. It is in a class of medications called vasopressin V2 receptor antagonists."

Answered by AI

What is the mechanism of action of tolvaptan?

"Tolvaptan's major action is to reduce water reabsorption in the renal collecting ducts, producing aquaresis (the excretion of water without sodium loss), and increasing free water clearance to correct dilutional hyponatraemia."

Answered by AI

What type of diuretic is tolvaptan?

"Tolvaptan is a diuretic that works on the part of the nephron closest to the hilus. It is an oral medication that competes with vasopressin for V2 receptors."

Answered by AI

What is tolvaptan used for?

"Tolvaptan is a medication used to treat low sodium levels in the blood in patients with heart failure or SIADH, and to slow the decline of kidney function in adults at risk of rapidly progressing ADPKD."

Answered by AI

Clinical Trials for Tolvaptan

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