Sufentanil Citrate

obstetrical analgesia therapy, lumbar epidural anesthesia therapy, Intubation (procedure) + 7 more

Treatment

8 FDA approvals

20 Active Studies for Sufentanil Citrate

Treatment for

obstetrical analgesia therapy

What is Sufentanil Citrate

SufentanilThe Generic name of this drug

Treatment SummarySufentanil is a type of opioid medication used to treat severe pain in adults. It can be administered through an intravenous (IV), epidural, or sublingual route. The sublingual form, also known as Dsuvia, is approved for use in medically supervised healthcare settings, such as hospitals, surgical centers, and emergency departments. It is intended to provide a fast and non-invasive way to manage acute pain.

Sufentanil Citrateis the brand name

Sufentanil Citrate Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Sufentanil Citrate

Sufentanil

1995

9

Approved as Treatment by the FDA

Sufentanil, also known as Sufentanil Citrate, is approved by the FDA for 8 uses including Major Surgical Procedures and Intubation (procedure) .

Major Surgical Procedures

Intubation (procedure)

Labor and Delivery

General Anesthesia

Induction and Maintenance of General Anesthesia

lumbar epidural anesthesia therapy

Used to treat lumbar epidural anesthesia therapy in combination with Bupivacaine

obstetrical analgesia therapy

Acute Pain

Effectiveness

How Sufentanil Citrate Affects PatientsSufentanil affects the central nervous system, respiratory system, cardiovascular system, and gastrointestinal tract. It is a painkiller and sedative, can increase pain tolerance and decrease the perception of pain, and can cause muscle rigidity and hypnotic activity. It can cause respiratory depression, peripheral vasodilation which may lead to hypotension or fainting, bradycardia, pruritus, flushing, red eyes, sweating and/or orthostatic hypotension. Sufentanil may also reduce motility in the stomach, delay digestion in the small intestine, decrease propulsive contractions in the

How Sufentanil Citrate works in the bodySufentanil is a strong opioid that binds to receptors in the brain, spinal cord, and other parts of the body. It helps reduce pain by affecting the neural pathways that send pain signals. It also decreases the release of pain-causing substances, and makes the cell membrane more stable. Sufentanil also blocks certain calcium channels, which stops the release of pain-causing neurotransmitters, and opens potassium channels, which causes the cells to become less active and less likely to send pain signals.

When to interrupt dosage

The measure of Sufentanil Citrate relies upon the diagnosed ailment, including lumbar epidural anesthesia therapy, Obstetric Delivery and Intubation (method). The magnitude of dosage fluctuates, according to the administration approach noted in the table beneath.

Condition

Dosage

Administration

General Anesthesia

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

lumbar epidural anesthesia therapy

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Major Surgical Procedures

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

short opioid analgesia requirement

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Induction and Maintenance of General Anesthesia

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Acute Pain

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Intubation (procedure)

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

obstetrical analgesia therapy

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Labor and Delivery

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Pain

0.05 mg/mL, , 0.015 mg, 0.03 mg

, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous

Warnings

Sufentanil Citrate has two contraindications, so it should not be taken if any of the conditions in the subsequent table are present.Sufentanil Citrate Contraindications

Condition

Risk Level

Notes

intolerance to opioid agonists

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Sufentanil may interact with Pulse Frequency

There are 20 known major drug interactions with Sufentanil Citrate.

Common Sufentanil Citrate Drug Interactions

Drug Name

Risk Level

Description

7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline

Major

The risk or severity of adverse effects can be increased when Sufentanil is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.

Azelastine

Major

Sufentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Benmoxin

Major

The risk or severity of adverse effects can be increased when Sufentanil is combined with Benmoxin.

Brofaromine

Major

The risk or severity of adverse effects can be increased when Sufentanil is combined with Brofaromine.

Caroxazone

Major

The risk or severity of adverse effects can be increased when Sufentanil is combined with Caroxazone.

Sufentanil Citrate Toxicity & Overdose RiskThe toxic dose of sufentanil in mice is 18.7mg/kg when given intravenously. Taking too much sufentanil can cause serious breathing problems, which may be fatal if not treated quickly. There is no evidence that sufentanil causes cancer or genetic damage in animals. In pregnant animals, sufentanil caused harm to the embryo when given at 2.5 times the maximum human dose. If taken during pregnancy, sufentanil may harm the fetus. If breastfeeding, infants should be monitored for excessive sleepiness or difficulty breathing.

image of a doctor in a lab doing drug, clinical research

Sufentanil Citrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Sufentanil Citrate?

22 active investigations are assessing the potential of Sufentanil Citrate to provide relief for Obstetric Delivery, Pain and Major Surgical Procedures.

Condition

Clinical Trials

Trial Phases

Major Surgical Procedures

0 Actively Recruiting

lumbar epidural anesthesia therapy

1 Actively Recruiting

Not Applicable

Pain

0 Actively Recruiting

short opioid analgesia requirement

0 Actively Recruiting

Intubation (procedure)

0 Actively Recruiting

General Anesthesia

3 Actively Recruiting

Not Applicable, Phase 3

obstetrical analgesia therapy

1 Actively Recruiting

Not Applicable

Induction and Maintenance of General Anesthesia

0 Actively Recruiting

Acute Pain

21 Actively Recruiting

Early Phase 1, Not Applicable, Phase 4, Phase 2, Phase 1

Labor and Delivery

0 Actively Recruiting

Patient Q&A Section about sufentanil citrate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is sufentanil an agonist?

"Fentanyl and its analogs produce potent analgesia when administered systemically to humans and other animals. These compounds have a rapid onset of action, are highly lipophilic, and cross the blood brain barrier readily.

Fentanyl and related drugs are very potent, specific μ-receptor agonists. They produce potent analgesia when administered systemically to humans and other animals and have a rapid onset of action. They are also highly lipophilic and cross the blood brain barrier readily."

Answered by AI

How is sufentanil eliminated?

"The main way that sufentanil is broken down is through N- and O- dealkylation, which gets rid of about 80% of the drug within 24 hours. Only 2% of the drug is eliminated without being changed."

Answered by AI

Clinical Trials for Sufentanil Citrate

Image of Pelvic Health and Continence Specialties in Rochester, United States.

TENS for Stress Incontinence

This trial will involve women with stress urinary incontinence undergoing a bulking procedure. They will be randomly assigned to two groups: one group will receive electrical nerve stimulation for pain relief during the procedure,

Waitlist Available

Pelvic Health and Continence Specialties

Image of Hopital du Sacre-Coeur de Montreal in Montreal, Canada.

Vitamin C for Acute Pain

Montreal, Canada

"This trial aims to determine if vitamin C can reduce pain intensity in patients with acute musculoskeletal pain over a seven-day period following an emergency department visit. Participants will either receive vitamin C or a placebo

Waitlist Available

Dietary Supplement

Hopital du Sacre-Coeur de MontrealRaoul Daoust, MD MSc

Image of Rhode Island Hospital in Providence, United States.

Ultrasound Guided Serratus Anterior Plane Block for Regional Anesthesia

"This trial aims to test a new method called Serratus Anterior Plane Block in patients with rib fractures. The trial wants to see if this new method can help reduce pain, improve breathing, and

Waitlist Available

Rhode Island Hospital

Image of Tufts Medical Center in Boston, United States.

TENS unit for Pain relief

"This trial involves screening subjects over the phone or at a clinic to see if they can participate. If eligible and interested, they will sign a consent form and then be enrolled in the study. Patients can

Waitlist Available

Tufts Medical CenterAndrea Zuckerman, MD

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Image of UVA Fontaine Research Park Building 415 in Charlottesville, United States.

Vibroacoustic for Laryngeal Cancer

Charlottesville, VA

This trial is looking at the use of vibration and augmented reality (AR) as non-medication options to help patients tolerate in-office procedures better. These procedures are a safe and cost-effective alternative to operating

UVA Fontaine Research Park Building 415James J Daniero, MD

Image of University of California, San Francisco in San Francisco, United States.

Ketamine + Talk Therapy for Pancreatic Cancer

San Francisco, CA

This trial tests if ketamine & talk therapy can reduce pain, anxiety & demoralization in PDAC patients taking opioids for cancer-related pain.

Waitlist Available

University of California, San FranciscoBrian T Anderson, MD

Image of Children's Hospital of Orange County in Orange, United States.

L-WebTIPS for Postoperative Pain in Children

This trial aims to reduce surgical disparities in Latinx children undergoing surgery by using a culturally adapted version of an existing mHealth intervention.

Children's Hospital of Orange County

Image of Brigham and Women's Hospital in Boston, United States.

Block upper extremity (arm) for Healthy Subjects

This trial is studying the effects of a nerve block in the arm during surgery. Nerve blocks are injections that numb the area and can help reduce pain after surgery. However, some patients may experience increased

Brigham and Women's HospitalYun-Yun K Chen, MD

Have you considered Sufentanil Citrate clinical trials? We made a collection of clinical trials featuring Sufentanil Citrate, we think they might fit your search criteria.

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Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Cryoneurolysis for Rib Fractures

Toronto, Canada

This trial will test if freezing nerves with a cold tool can reduce pain from broken ribs, compared to the usual methods.

Senior-friendly

Sunnybrook Health Sciences CentreBen Safa, MD

Image of University of Delaware in Newark, United States.

Pain Impact on Motor Skills Learning Retention

This trial investigates whether pain affects our ability to learn and remember motor skills, and if so, if it's due to pain or a change in context.

University of DelawareSusanne M Morton, PhD

Image of Hôpital du Sacré-Coeur de Montréal in Montréal, Canada.

Vitamin C for Acute Pain

Montréal, Canada

This trial aims to study whether taking vitamin C can reduce the amount of opioid pills needed for pain relief in patients discharged from the emergency department with acute musculoskeletal pain. The study will compare the use

Hôpital du Sacré-Coeur de MontréalRaoul Daoust, MD MSc

Image of Summa Health System in Akron, United States.

Ketamine for Acute Pain

This trial is studying whether a longer or shorter infusion of ketamine reduces side effects in people with severe pain in the emergency department.

Summa Health SystemMichael Pallaci, DO, FACEP

Have you considered Sufentanil Citrate clinical trials? We made a collection of clinical trials featuring Sufentanil Citrate, we think they might fit your search criteria.

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