Sufentanil Citrate
obstetrical analgesia therapy, lumbar epidural anesthesia therapy, Intubation (procedure) + 7 more
Treatment
9 FDA approvals
4 Active Studies for Sufentanil Citrate
Treatment for
obstetrical analgesia therapy
What is Sufentanil Citrate
Sufentanil
The Generic name of this drug
Treatment Summary
Sufentanil is a type of opioid medication used to treat severe pain in adults. It can be administered through an intravenous (IV), epidural, or sublingual route. The sublingual form, also known as Dsuvia, is approved for use in medically supervised healthcare settings, such as hospitals, surgical centers, and emergency departments. It is intended to provide a fast and non-invasive way to manage acute pain.
Sufentanil Citrate
is the brand name
Sufentanil Citrate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Sufentanil Citrate
Sufentanil
1995
9
Approved as Treatment by the FDA
Sufentanil, also known as Sufentanil Citrate, is approved by the FDA for 9 uses including Intubation (procedure) and lumbar epidural anesthesia therapy .
Intubation (procedure)
lumbar epidural anesthesia therapy
Used to treat lumbar epidural anesthesia therapy in combination with Bupivacaine
obstetrical analgesia therapy
Pain, Acute
Induction and Maintenance of General Anesthesia
Acute Pain
Labor and Delivery
General Anesthesia
Major Surgical Procedures
Effectiveness
How Sufentanil Citrate Affects Patients
Sufentanil affects the central nervous system, respiratory system, cardiovascular system, and gastrointestinal tract. It is a painkiller and sedative, can increase pain tolerance and decrease the perception of pain, and can cause muscle rigidity and hypnotic activity. It can cause respiratory depression, peripheral vasodilation which may lead to hypotension or fainting, bradycardia, pruritus, flushing, red eyes, sweating and/or orthostatic hypotension. Sufentanil may also reduce motility in the stomach, delay digestion in the small intestine, decrease propulsive contractions in the
How Sufentanil Citrate works in the body
Sufentanil is a strong opioid that binds to receptors in the brain, spinal cord, and other parts of the body. It helps reduce pain by affecting the neural pathways that send pain signals. It also decreases the release of pain-causing substances, and makes the cell membrane more stable. Sufentanil also blocks certain calcium channels, which stops the release of pain-causing neurotransmitters, and opens potassium channels, which causes the cells to become less active and less likely to send pain signals.
When to interrupt dosage
The measure of Sufentanil Citrate relies upon the diagnosed ailment, including lumbar epidural anesthesia therapy, Obstetric Delivery and Intubation (method). The magnitude of dosage fluctuates, according to the administration approach noted in the table beneath.
Condition
Dosage
Administration
General Anesthesia
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Major Surgical Procedures
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Labor and Delivery
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Acute Pain
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Induction and Maintenance of General Anesthesia
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
short opioid analgesia requirement
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Pain
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
obstetrical analgesia therapy
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
lumbar epidural anesthesia therapy
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Intubation (procedure)
0.05 mg/mL, , 0.015 mg, 0.03 mg
, Epidural; Intravenous, Injection, Injection - Epidural; Intravenous, Solution, Solution - Epidural; Intravenous, Liquid, Liquid - Epidural; Intravenous, Intravenous, Liquid - Intravenous, Sublingual, Tablet, Tablet - Sublingual, Injection, solution, Injection, solution - Epidural; Intravenous, Solution - Intravenous
Warnings
Sufentanil Citrate has two contraindications, so it should not be taken if any of the conditions in the subsequent table are present.
Sufentanil Citrate Contraindications
Condition
Risk Level
Notes
intolerance to opioid agonists
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Sufentanil may interact with Pulse Frequency
There are 20 known major drug interactions with Sufentanil Citrate.
Common Sufentanil Citrate Drug Interactions
Drug Name
Risk Level
Description
7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline
Major
The risk or severity of adverse effects can be increased when Sufentanil is combined with 7,8-Dichloro-1,2,3,4-tetrahydroisoquinoline.
Azelastine
Major
Sufentanil may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Benmoxin
Major
The risk or severity of adverse effects can be increased when Sufentanil is combined with Benmoxin.
Brofaromine
Major
The risk or severity of adverse effects can be increased when Sufentanil is combined with Brofaromine.
Caroxazone
Major
The risk or severity of adverse effects can be increased when Sufentanil is combined with Caroxazone.
Sufentanil Citrate Toxicity & Overdose Risk
The toxic dose of sufentanil in mice is 18.7mg/kg when given intravenously. Taking too much sufentanil can cause serious breathing problems, which may be fatal if not treated quickly. There is no evidence that sufentanil causes cancer or genetic damage in animals. In pregnant animals, sufentanil caused harm to the embryo when given at 2.5 times the maximum human dose. If taken during pregnancy, sufentanil may harm the fetus. If breastfeeding, infants should be monitored for excessive sleepiness or difficulty breathing.
Sufentanil Citrate Novel Uses: Which Conditions Have a Clinical Trial Featuring Sufentanil Citrate?
22 active investigations are assessing the potential of Sufentanil Citrate to provide relief for Obstetric Delivery, Pain and Major Surgical Procedures.
Condition
Clinical Trials
Trial Phases
lumbar epidural anesthesia therapy
0 Actively Recruiting
obstetrical analgesia therapy
1 Actively Recruiting
Not Applicable
Labor and Delivery
1 Actively Recruiting
Phase 3
Intubation (procedure)
0 Actively Recruiting
Induction and Maintenance of General Anesthesia
0 Actively Recruiting
Pain
0 Actively Recruiting
Acute Pain
1 Actively Recruiting
Not Applicable
General Anesthesia
1 Actively Recruiting
Phase 4
Major Surgical Procedures
0 Actively Recruiting
short opioid analgesia requirement
0 Actively Recruiting
Patient Q&A Section about sufentanil citrate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Is sufentanil an agonist?
"Fentanyl and its analogs produce potent analgesia when administered systemically to humans and other animals. These compounds have a rapid onset of action, are highly lipophilic, and cross the blood brain barrier readily.
Fentanyl and related drugs are very potent, specific μ-receptor agonists. They produce potent analgesia when administered systemically to humans and other animals and have a rapid onset of action. They are also highly lipophilic and cross the blood brain barrier readily."
Answered by AI
How is sufentanil eliminated?
"The main way that sufentanil is broken down is through N- and O- dealkylation, which gets rid of about 80% of the drug within 24 hours. Only 2% of the drug is eliminated without being changed."
Answered by AI