Prinivil

Migraine, Heart Attack, prophylaxis of cardiovascular event + 6 more
Treatment
5 FDA approvals
20 Active Studies for Prinivil

What is Prinivil

LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is a medication used to treat high blood pressure, heart failure, and after a heart attack. It is an angiotensin converting enzyme (ACE) inhibitor, which means it helps to reduce the amount of pressure in the blood vessels. It is usually prescribed as the first line of treatment for hypertension, along with diuretics or beta blockers. Lisinopril was approved by the FDA in 1987.
Prinivilis the brand name
image of different drug pills on a surface
Prinivil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222

Approved as Treatment by the FDA

Lisinopril, commonly known as Prinivil, is approved by the FDA for 5 uses which include Congestive Heart Failure (CHF) and Hypertensive disease .
Congestive Heart Failure (CHF)
Used in combination with other therapies
Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Acute Myocardial Infarction (AMI)
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)

Effectiveness

How Prinivil Affects PatientsLisinopril works by slowing down the enzyme (angiotensin II) and hormone system (renin angiotensin aldosterone system, or RAAS) that regulate blood pressure and blood flow in the body. It is considered to be very safe, and usually produces long lasting effects when the right dose (10-80mg) is taken daily.
How Prinivil works in the bodyLisinopril works by blocking an enzyme called angiotensin converting enzyme (ACE). This enzyme is responsible for turning angiotensin I into angiotensin II. Without ACE, the angiotensin II cannot constrict coronary blood vessels or lead to myocyte hypertrophy or vascular smooth muscle cell proliferation. Lisinopril also increases the levels of bradykinin, which has vasodilating effects, and prevents renin from converting angiotensin to angiotensin I.

When to interrupt dosage

The suggested dosage of Prinivil is contingent upon the diagnosed condition, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The measure of dosage is contingent upon the mode of delivery (e.g. Tablet - Oral or Tablet) provided in the table beneath.
Condition
Dosage
Administration
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetic Nephropathies
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Migraine Disorders
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral

Warnings

Prinivil Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
There are 20 known major drug interactions with Prinivil.
Common Prinivil Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Prinivil Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
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Prinivil Novel Uses: Which Conditions Have a Clinical Trial Featuring Prinivil?

647 active trials are underway to investigate the potential of Prinivil in alleviating Type 2 Diabetes, Diabetic Nephropathy and Hypertensive conditions.
Condition
Clinical Trials
Trial Phases
Diabetes
74 Actively Recruiting
Phase 1, Not Applicable, Phase 4, Phase 2, Phase 3
Migraine Disorders
1 Actively Recruiting
Phase 3
Diabetic Nephropathies
0 Actively Recruiting
prophylaxis of cardiovascular event
0 Actively Recruiting
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Migraine
53 Actively Recruiting
Phase 4, Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1
Cardiovascular Events
4 Actively Recruiting
Not Applicable
Heart Attack
7 Actively Recruiting
Not Applicable, Phase 4, Phase 3

Prinivil Reviews: What are patients saying about Prinivil?

5Patient Review
7/6/2015
Prinivil for High Blood Pressure
I've been taking lisinopril for over 20 years. It's a great drug; it works well and I haven't experienced any side effects.
5Patient Review
1/18/2014
Prinivil for High Blood Pressure
I've been taking Lisinopril for eight years and have never experienced any negative side effects. I would definitely recommend it to others who are in a similar situation as me.
5Patient Review
4/25/2012
Prinivil for High Blood Pressure
I'm surprised at all of the side effects that other users are experiencing. I have not experienced any, that I'm aware of. My blood pressure was high, but not severe. My BP now is around the 120/80 range give or take 10 on either. Once I was put on Lisinopril, I felt like a new man.
5Patient Review
8/1/2012
Prinivil for High Blood Pressure
So far, I'm really pleased with this medication. It's only been one dose, but it has already lowered my blood pressure.
4.7Patient Review
3/22/2014
Prinivil for High Blood Pressure
My blood pressure was very high when I started taking this medication. In only five days, it has come down significantly. My doctor had faith in this drug and it really delivered!
View All Reviews
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Patient Q&A Section about prinivil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Prinivil and side effects?

"The potential side effects of Prinivil include feeling light-headed or dizzy, as well as fever, sore throat, and high potassium levels. Kidney problems, such as decreased urination or swelling in the feet or ankles, may also occur. Some people may also experience chest pain, irregular heartbeats, or loss of movement."

Answered by AI

Is lisinopril and Prinivil the same?

"Are Zestril and Prinivil the same thing?

Zestril and Prinivil are both brand names for the medication lisinopril, which is used to treat different conditions such as high blood pressure and heart failure."

Answered by AI

Does Prinivil have a diuretic in it?

"This medication is used to treat heart failure and improve survival after a heart attack. It works by relaxing blood vessels and reducing the workload on the heart. It is also used to treat high blood pressure. This medication contains two types of drugs: an ACE inhibitor and a thiazide diuretic."

Answered by AI

What is the medication Prinivil used for?

"High blood pressure can lead to a number of health problems, including strokes, heart attacks, and kidney problems. Lowering high blood pressure can help prevent these problems. It can also be used to treat heart failure and improve survival after a heart attack."

Answered by AI

Clinical Trials for Prinivil

Have you considered Prinivil clinical trials? We made a collection of clinical trials featuring Prinivil, we think they might fit your search criteria.
Have you considered Prinivil clinical trials? We made a collection of clinical trials featuring Prinivil, we think they might fit your search criteria.
Have you considered Prinivil clinical trials? We made a collection of clinical trials featuring Prinivil, we think they might fit your search criteria.
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