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What is Prinivil
LisinoprilThe Generic name of this drug
Treatment SummaryLisinopril is a medication used to treat high blood pressure, heart failure, and after a heart attack. It is an angiotensin converting enzyme (ACE) inhibitor, which means it helps to reduce the amount of pressure in the blood vessels. It is usually prescribed as the first line of treatment for hypertension, along with diuretics or beta blockers. Lisinopril was approved by the FDA in 1987.
Prinivilis the brand name
Prinivil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Prinivil
Lisinopril
1987
1222
Approved as Treatment by the FDA
Lisinopril, commonly known as Prinivil, is approved by the FDA for 3 uses which include Hypertensive disease and Heart Attack .Hypertensive disease
Helps manage High Blood Pressure (Hypertension)
Heart Attack
Helps manage Acute Myocardial Infarction (AMI)
Congestive Heart Failure
Used in combination with other therapies
Effectiveness
How Prinivil Affects PatientsLisinopril works by slowing down the enzyme (angiotensin II) and hormone system (renin angiotensin aldosterone system, or RAAS) that regulate blood pressure and blood flow in the body. It is considered to be very safe, and usually produces long lasting effects when the right dose (10-80mg) is taken daily.
How Prinivil works in the bodyLisinopril works by blocking an enzyme called angiotensin converting enzyme (ACE). This enzyme is responsible for turning angiotensin I into angiotensin II. Without ACE, the angiotensin II cannot constrict coronary blood vessels or lead to myocyte hypertrophy or vascular smooth muscle cell proliferation. Lisinopril also increases the levels of bradykinin, which has vasodilating effects, and prevents renin from converting angiotensin to angiotensin I.
When to interrupt dosage
The suggested dosage of Prinivil is contingent upon the diagnosed condition, including Migraine, Congestive Heart Failure and prophylaxis of cardiovascular event. The measure of dosage is contingent upon the mode of delivery (e.g. Tablet - Oral or Tablet) provided in the table beneath.Condition
Dosage
Administration
Diabetes
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Heart Attack
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of cardiovascular event
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
prophylaxis of migraine headaches
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Congestive Heart Failure
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Diabetic Nephropathy
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Hypertensive disease
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Migraine
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Cardiovascular Events
, 2.5 mg, 5.0 mg, 10.0 mg, 20.0 mg, 30.0 mg, 40.0 mg, 0.1 mg, 1.0 mg/mL
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit, Solution, Solution - Oral
Warnings
Prinivil ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Type 2 Diabetes
Do Not Combine
Angioedema
Do Not Combine
Pulse Frequency
Do Not Combine
Angioedemas, Hereditary
Do Not Combine
Common Prinivil Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Lisinopril may increase the hypotensive activities of Amifostine.
Azathioprine
Major
The risk or severity of myelosuppression, anemia, and severe leukopenia can be increased when Lisinopril is combined with Azathioprine.
Lithium carbonate
Major
The serum concentration of Lithium carbonate can be increased when it is combined with Lisinopril.
Lithium citrate
Major
The serum concentration of Lithium citrate can be increased when it is combined with Lisinopril.
Lithium hydroxide
Major
The serum concentration of Lithium hydroxide can be increased when it is combined with Lisinopril.
Prinivil Toxicity & Overdose RiskThe lowest toxic dose of lisinopril in rats has been found to be greater than 8500mg/kg in rats and greater than 9100mg/kg in mice. Those who overdose on lisinopril may experience low blood pressure, which can be reversed by administering saline intravenously. Since lisinopril does not bind to protein, dialysis can be used to remove the drug from the bloodstream.
Prinivil Novel Uses: Which Conditions Have a Clinical Trial Featuring Prinivil?
647 active trials are underway to investigate the potential of Prinivil in alleviating Type 2 Diabetes, Diabetic Nephropathy and Hypertensive conditions.Condition
Clinical Trials
Trial Phases
Migraine
52 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Phase 4, Early Phase 1
Heart Attack
8 Actively Recruiting
Not Applicable, Phase 4, Phase 3
prophylaxis of cardiovascular event
0 Actively Recruiting
Diabetes
542 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Phase 4, Early Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Diabetic Nephropathy
1 Actively Recruiting
Phase 4
prophylaxis of migraine headaches
0 Actively Recruiting
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Cardiovascular Events
3 Actively Recruiting
Not Applicable
Prinivil Reviews: What are patients saying about Prinivil?
5Patient Review
7/6/2015 I've been taking lisinopril for over 20 years. It's a great drug; it works well and I haven't experienced any side effects.
5Patient Review
1/18/2014 I've been taking Lisinopril for eight years and have never experienced any negative side effects. I would definitely recommend it to others who are in a similar situation as me.
5Patient Review
4/25/2012 I'm surprised at all of the side effects that other users are experiencing. I have not experienced any, that I'm aware of. My blood pressure was high, but not severe. My BP now is around the 120/80 range give or take 10 on either. Once I was put on Lisinopril, I felt like a new man.
5Patient Review
8/1/2012 So far, I'm really pleased with this medication. It's only been one dose, but it has already lowered my blood pressure.
4.7Patient Review
3/22/2014 My blood pressure was very high when I started taking this medication. In only five days, it has come down significantly. My doctor had faith in this drug and it really delivered!
4.3Patient Review
6/18/2011 I'm an older woman who had been dealing with slightly high blood pressure. Lisinopril has helped to control my BP, but the annoying cough/post-nasal drip is making me second guess whether or not I want to continue taking it. It's a shame because it was working so well for me up until this point.
4.3Patient Review
3/27/2012 I've been taking linsopril with hcl diretic for a while now and it does seem to lower my blood pressure. I don't always have an erection anymore and this is really causing problems in my sex life. If any other men are experiencing this, please let me know.
3.7Patient Review
5/12/2011 For the most part, this drug worked very well for me. However, I suddenly had a severe allergic reaction to it about a year in. My tongue started swelling and within an hour I couldn't talk or swallow. Thankfully, I was able to get some relief through IV steroids and antihistamines in the ER, but it took a week of oral steroids and antihistamines to get completely back to normal.
3.7Patient Review
10/1/2016 I was on lisinopril for almost a decade before I had an allergic reaction that caused my airway to swell shut. Thankfully, I recovered and am now on norvasc. If you can handle this drug it's great, but if you can't then be warned: the side effect could kill you.
3.3Patient Review
12/6/2011 While this drug was successful in lowering my blood pressure, it unfortunately also caused a relentless and debilitating cough. I discontinued use a couple weeks ago but have yet to see any real improvement.
3.3Patient Review
1/25/2011 I had a severe reaction to this drug in the form of anxiety. I would have panic attacks about things that didn't make any sense, and when I tried to sleep I would have nightmares. The people at the pharmacy said this was a rare reaction, but it was really intense while it lasted.
3.3Patient Review
5/23/2012 My blood pressure has not been well-controlled since starting this medication.
2.7Patient Review
2/23/2011 Within two months of taking 30 mg of lisinopril, I gained over 20 pounds despite maintaining my regular exercise routine. I also felt more sluggish and less able to focus. Once I stopped taking the medication, I immediately felt better.
2.3Patient Review
4/11/2011 I'm taking 50 mg of atenolol twice daily, 10 mg. of norvasc, and 40 mg. of prinivil but my blood pressure is still high
2.3Patient Review
1/12/2014 I had a severe reaction to this medicine and it was incredibly dangerous. Do not take this drug.
2Patient Review
11/27/2010 This cough is really irritating and makes it hard to breathe.
1Patient Review
9/14/2011 I'm active, and I was playing golf and doing jazzercise about three times a week when my doctor told me my creatinine level was getting bad. He recommended lisinopril, but the generic version from the pharmacy gave me severe headaches. I also experienced sneezing and cold symptoms.
Patient Q&A Section about prinivil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is Prinivil and side effects?
"The potential side effects of Prinivil include feeling light-headed or dizzy, as well as fever, sore throat, and high potassium levels. Kidney problems, such as decreased urination or swelling in the feet or ankles, may also occur. Some people may also experience chest pain, irregular heartbeats, or loss of movement."
Answered by AI
Is lisinopril and Prinivil the same?
"Are Zestril and Prinivil the same thing?
Zestril and Prinivil are both brand names for the medication lisinopril, which is used to treat different conditions such as high blood pressure and heart failure."
Answered by AI
Does Prinivil have a diuretic in it?
"This medication is used to treat heart failure and improve survival after a heart attack. It works by relaxing blood vessels and reducing the workload on the heart. It is also used to treat high blood pressure. This medication contains two types of drugs: an ACE inhibitor and a thiazide diuretic."
Answered by AI
What is the medication Prinivil used for?
"High blood pressure can lead to a number of health problems, including strokes, heart attacks, and kidney problems. Lowering high blood pressure can help prevent these problems. It can also be used to treat heart failure and improve survival after a heart attack."
Answered by AI