Colonoscopy Preparation for Diabetes
What You Need to Know Before You Apply
What is the purpose of this trial?
Patients with diabetes have less effective colonoscopy preparation when compared to nondiabetic patients. This leads to the possibility of missed polyps, longer procedural time and patient dissatisfaction. Furthermore, the peri-colonoscopy period has been associated with increased risk of hypoglycemic events given the required change in diet and possible changes in antihyperglycemic medication regime, though this area is not well studied.
Studies have found that same day preparation for colonoscopy allowed for comparable bowel visualization to split dosing. Pairing this with a low fiber diet permitted the day prior to colonoscopy, the extent of changes to routine and diet within a patient with diabetes day for colonoscopy preparation is minimized and could reduce risk of side effects and hypoglycemia, while also ensuring adequate bowel preparation.
This study tests the hypothesis that creating a diabetic specific protocol (permitting a low fibre diet the day prior to colonoscopy and using same day preparation) will result in fewer hypoglycemic events and more adequate quality preparation in comparison to a conventional 2L PEG split day preparation with dietary restrictions in patients with diabetes.
Are You a Good Fit for This Trial?
Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dietary Preparation
Participants follow a specific dietary protocol prior to colonoscopy. Control group follows a clear-liquid diet after breakfast the day before colonoscopy. Experimental group follows a four-day, low-fiber carbohydrate diet.
Bowel Preparation
Participants ingest PEG solution as part of bowel preparation. Control group ingests 2L of PEG the evening before and 2L four hours prior to colonoscopy. Experimental group ingests 2L of PEG between 5:00 AM and 6:00 AM and the remaining 2L between 8:00 AM and 9:00 AM on the day of the procedure.
Colonoscopy and Monitoring
Participants undergo colonoscopy and are monitored for bowel preparation adequacy and hypoglycemic events.
Follow-up
Participants are monitored for safety and effectiveness after the colonoscopy, including patient-reported ratings of convenience, tolerability, and adverse events.
What Are the Treatments Tested in This Trial?
Interventions
- Diabetic Specific Protocol
How Is the Trial Designed?
2
Treatment groups
Experimental Treatment
Active Control
Participants will follow a four-day, low-fiber carbohydrate diet. They will be allowed to consume dinner up until 7:00 PM the night before the colonoscopy. On the day of the procedure, they will ingest 2L of PEG between 5:00 AM and 6:00 AM and the remaining 2L between 8:00 AM and 9:00 AM.
Participants will follow a clear-liquid diet after breakfast on the day before colonoscopy. They will ingest 2L of PEG at 7:00 PM the evening before the procedure and the remaining 2L four hours prior to colonoscopy.
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Who Is Running the Clinical Trial?
Queen's University
Lead Sponsor
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