Penicillin G Potassium

Gas Gangrene, Botulism, Anthrax + 20 more

Treatment

20 Active Studies for Penicillin G Potassium

Treatment for

Gas Gangrene

What is Penicillin G Potassium

Benzylpenicillin

The Generic name of this drug

Treatment Summary

Benzylpenicillin (Penicillin G) is an antibiotic used to treat bacterial infections. It is typically given intravenously or intramuscularly since it can’t be absorbed orally. Penicillin G is most effective against certain types of gram-positive bacteria, such as streptococci, staphylococci, and certain bacilli. In some cases, it may also be used to prevent infection. It is not typically used to treat anaerobic infections and may not be effective against gram-negative bacteria. Different regions may have different resistance patterns and treatment guidelines.

Bicillin L-A

is the brand name

image of different drug pills on a surface

Penicillin G Potassium Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bicillin L-A

Benzylpenicillin

1952

Effectiveness

How Penicillin G Potassium Affects Patients

Penicillin G is an antibiotic used to treat infections caused by certain bacteria. It is effective against both gram-positive and gram-negative bacteria. The way it works is by preventing the bacteria from making a protective wall around itself, which stops the infection from spreading. Penicillin G is also resistant to many types of enzymes that can break down antibiotics, which makes it a powerful drug.

How Penicillin G Potassium works in the body

Penicillin G works by attaching to proteins in the bacterial cell wall. This prevents the bacteria from forming a protective wall, which leads to its eventual destruction. Penicillin G may also interfere with a molecule that stops the bacteria from destroying itself.

When to interrupt dosage

The advocated dosage of Penicillin G Potassium is based upon the diagnosed disorder, such as rat bite fever, Haverhill fever and Actinomycosis. The dosage itself is contingent upon the technique of delivery (e.g. Intramuscular; Intravenous or Injection, suspension) specified in the table beneath.

Condition

Dosage

Administration

Botulism

, 5000000.0 [iU], 20000000.0 [iU], 5000000.0 [USP'U], 1200000.0 [iU]/mL, 5000000.0 units, 1000000.0 units, 10000000.0 units, 500000.0 units, 600000.0 [iU]/mL, 2400000.0 [iU]/mL, 100000.0 [iU]/mL, 200000.0 [iU]/mL, 300000.0 [iU]/mL, 1000000.0 [iU], 900000.0 [iU]/mL, 500000.0 units/mL, 1200000.0 units/mL, 250000.0 units/mL, 900000.0 units/mL, 300000.0 units/mL

Injection, powder, for solution - Intramuscular; Intravenous, , Intramuscular; Intravenous, Injection, powder, for solution, Powder, for solution, Powder, for solution - Intramuscular; Intrapleural; Intrathecal; Intravenous, Intravenous, Powder, for solution - Intravenous, Intramuscular; Intrapleural; Intrathecal; Intravenous, Powder, for solution - Intramuscular; Intravenous, Tablet - Oral, Oral, Tablet, Intramuscular; Intravenous; Topical, Powder, for solution - Intramuscular; Intravenous; Topical, Suspension, Suspension - Intramuscular, Suspension - Oral, Injection, suspension - Intramuscular, Injection, suspension, Intramuscular, Injection, solution, Injection, solution - Intravenous, Injection, powder, for solution - Intravenous, Powder, for solution - Intramuscular

Empyema

Pericarditis

Gonorrhea

Fusospirochetosis

Rat-Bite Fever

Rheumatic Fever

Actinomycosis

Listeriosis

Endocarditis

Lockjaw

Syphilis

Endocarditis

Communicable Diseases

Rat-Bite Fever

Meningitis, Meningococcal

Gas Gangrene

Anthrax

Diphtheria

Bacterial Meningitis

Warnings

Penicillin G Potassium bears one contraindication and should not be joined with the conditions given in the subsequent table.

Penicillin G Potassium Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Benzylpenicillin may interact with Pulse Frequency

There are 20 known major drug interactions with Penicillin G Potassium.

Common Penicillin G Potassium Drug Interactions

Drug Name

Risk Level

Description

Vibrio cholerae CVD 103-HgR strain live antigen

Major

The therapeutic efficacy of Vibrio cholerae CVD 103-HgR strain live antigen can be decreased when used in combination with Benzylpenicillin.

Adefovir dipivoxil

Minor

The excretion of Adefovir dipivoxil can be decreased when combined with Benzylpenicillin.

Chlormadinone

Minor

The therapeutic efficacy of Chlormadinone can be decreased when used in combination with Benzylpenicillin.

Cidofovir

Minor

The excretion of Cidofovir can be decreased when combined with Benzylpenicillin.

Cloprostenol

Minor

The therapeutic efficacy of Cloprostenol can be decreased when used in combination with Benzylpenicillin.

Penicillin G Potassium Toxicity & Overdose Risk

The amount of Amoxicillin that would be toxic to rats is 8900mg/kg. Taking a high dose of Amoxicillin for over two weeks can lead to neurological side effects such as seizures and lowered white blood cell counts.

image of a doctor in a lab doing drug, clinical research

Penicillin G Potassium Novel Uses: Which Conditions Have a Clinical Trial Featuring Penicillin G Potassium?

Condition

Clinical Trials

Trial Phases

Pneumonia

17 Actively Recruiting

Not Applicable, Early Phase 1, Phase 2, Phase 4

Lockjaw

0 Actively Recruiting

Communicable Diseases

0 Actively Recruiting

Rheumatic Fever

0 Actively Recruiting

Botulism

0 Actively Recruiting

Bacterial Meningitis

0 Actively Recruiting

Fusospirochetosis

0 Actively Recruiting

Meningitis, Meningococcal

0 Actively Recruiting

Anthrax

1 Actively Recruiting

Phase 2

Gram-Negative Bacterial Infections

0 Actively Recruiting

Gas Gangrene

0 Actively Recruiting

Empyema

1 Actively Recruiting

Phase 4

Listeriosis

0 Actively Recruiting

Actinomycosis

0 Actively Recruiting

Diphtheria

0 Actively Recruiting

Rat-Bite Fever

0 Actively Recruiting

Endocarditis

0 Actively Recruiting

Pericarditis

2 Actively Recruiting

Phase 2, Phase 3

Endocarditis

1 Actively Recruiting

Not Applicable

Sepsis

1 Actively Recruiting

Not Applicable

Penicillin G Potassium Reviews: What are patients saying about Penicillin G Potassium?

1.7

Patient Review

11/14/2008

Penicillin G Potassium for Bacterial Meningitis caused by Streptococcus

How do I book an appointment for a checkup?

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about penicillin g potassium

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does penicillin G have potassium?

"This injection contains 1.7 million units of potassium and 1.02 million units of sodium."

Answered by AI

What is penicillin G potassium used for?

"This medication is used to treat a wide variety of bacterial infections, as well as to prevent infection of the heart (bacterial endocarditis) in patients with certain heart diseases who are having surgery. This medication, which is a natural penicillin antibiotic, works by stopping the growth of bacteria."

Answered by AI

What is the difference between penicillin and penicillin G?

"Penicillin G is produced by fermentation ofPenicillium crysogenum and is a natural penicillin. Penicillin V is derived from penicillin G and has a similar spectrum of activity, making it a natural penicillin as well."

Answered by AI

What type of drug is penicillin G potassium?

"It works by fighting bacteria in your body.

Penicillin G Potassium is a Natural Penicillin that works by fighting bacteria in your body."

Answered by AI

Clinical Trials for Penicillin G Potassium

Image of Children's of Alabama in Birmingham, United States.

Antibiotic Duration for Infections in Children

60 - 17

All Sexes

Birmingham, AL

Infections like pneumonia, skin and soft tissue infection (also called SSTI or cellulitis), and urinary tract infections (UTI) are some of the most common reasons children get admitted to the hospital. All three of these conditions require antibiotics for treatment. Although antibiotics are needed to treat the infection and help children feel better, taking them longer than needed can negatively impact children and their families. Negative impacts include things like the burdens of taking more medications and medication side effects. There are guidelines (instructions) from expert medical organizations that suggest the number of days children need antibiotics, but they give a wide range (between 5 and 14 days). Unfortunately, these guidelines are not based on high-quality studies. National data suggests that doctors often choose on the higher end of this range when writing prescriptions for children in the hospital. Our three caregiver co-investigators, other parents of hospitalized children, doctors, other care providers, and researchers, all believe that additional study is needed to determine the best length of antibiotic treatment that weighs both the benefits and harms of antibiotics. The goal of our study is to understand if 5 total days of antibiotic treatment compared to 10 total days of antibiotic treatment is better for children who have been in the hospital for pneumonia, SSTI, or UTI. We will study this question through a randomized control trial. In other words, half of the children will receive 5-days of antibiotics and the other half will receive 10-days of antibiotics. Children in this study (and their caregivers) will not know how many days of antibiotics they will receive to cure their infection because some children will take a placebo (or a pill without antibiotics in it). Only the pharmacy will know if a child is getting antibiotic or placebo (for days 6-10 of treatment). During the first phase of the trial (feasibility phase), 4 hospitals will enroll children in the study. We plan on enrolling 50 patients during this phase. We are starting with just 4 hospitals, so our study team can create and update our study plans if needed. We will closely review information about how many patients and families agree to participate, and if they have any trouble completing any part of the study. We will also interview families to understand the choice to participate in the study, the choice not to participate in the study, and what it is like to be in the study. During the second study phase, we will enroll 1150 more patients across all 11 hospitals. Families will complete short, daily surveys until the 15th day after they started antibiotics, then a larger survey at day 15, at day 20, and at day 30. These surveys will ask about the child's symptoms and recovery from their illness, how the antibiotics are making them feel, and if they had to go back to their doctor, emergency room, or hospital. The answers to these questions will be combined to measure how well the child did, balancing feeling better and having bad effects from the antibiotics. We will use mathematical tests to determine which antibiotic duration is better for treating these illnesses. We will complete other mathematical tests to see if all children should receive the same length of antibiotics or if certain children should be prescribed shorter courses and others longer courses.

Phase 4

Waitlist Available

Drug

Children's of Alabama (+9 Sites)

Sunitha V Kaiser, MD, MSc