Your session is about to expire
What is Pamelor
NortriptylineThe Generic name of this drug
Treatment SummaryNortriptyline hydrochloride is an antidepressant medication used to treat major depression. It is also sometimes prescribed for chronic pain and other conditions, even though it is not approved for these uses. It is a type of tricyclic antidepressant that is derived from amitriptyline.
Pameloris the brand name
Pamelor Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Pamelor
Nortriptyline
1977
190
Approved as Treatment by the FDA
Nortriptyline, also known as Pamelor, is approved by the FDA for 1 uses including Depression .Depression
Effectiveness
How Pamelor Affects PatientsNortriptyline works as an antidepressant by blocking the removal of serotonin and norepinephrine from cells in the brain. It also blocks certain receptors in the body which can lead to muscle relaxation.
How Pamelor works in the bodyNortriptyline is believed to either stop nerves from reabsorbing serotonin or act on beta-adrenergic receptors. It is more effective at preventing the reabsorption of noradrenaline, which can explain why it's helpful for improving symptoms. Unlike other tricyclic antidepressants, nortriptyline does not impact monoamine oxidase or dopamine reuptake. It also has an affinity for mACh receptors, histamine receptors, and 5-HT receptors.
When to interrupt dosage
The measure of Pamelor is conditioned by the diagnosed affliction, including Irritable Bowel Syndrome (IBS), Depression and Chronic Pain. The measure of dosage evolves, as per the technique of administration (e.g. Oral or Capsule) delineated in the table beneath.Condition
Dosage
Administration
Pain, Orofacial
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Depression
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Irritable Bowel Syndrome (IBS)
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Postherpetic Neuralgia
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Chronic Pain
10.0 mg, , 25.0 mg, 50.0 mg, 75.0 mg, 10.0 mg/mL, 2.0 mg/mL
, Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Tablet - Oral, Tablet
Warnings
Pamelor ContraindicationsCondition
Risk Level
Notes
Dibenzazepines
Do Not Combine
Myocardial Infarction
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Nortriptyline may interact with Pulse Frequency
Common Pamelor Drug Interactions
Drug Name
Risk Level
Description
Acepromazine
Major
Nortriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Acepromazine.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Nortriptyline is combined with Aclidinium.
Alfuzosin
Major
Nortriptyline may increase the hypotensive activities of Alfuzosin.
Amoxapine
Major
Nortriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Amoxapine.
Aripiprazole
Major
Nortriptyline may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole.
Pamelor Toxicity & Overdose RiskThe lowest toxic dose of nortriptyline in rats is 405 mg/kg. Overdosing on nortriptyline can lead to abnormal heart rhythms, dangerously low blood pressure, shock, heart failure, fluid in the lungs, seizures, loss of consciousness, and central nervous system depression. Changes in the electrocardiogram may also be seen with nortriptyline toxicity.
Pamelor Novel Uses: Which Conditions Have a Clinical Trial Featuring Pamelor?
222 active studies are presently being conducted to evaluate the potential of Pamelor in providing relief from Pain, Orofacial, Depression and Irritable Bowel Syndrome (IBS).Condition
Clinical Trials
Trial Phases
Pain, Orofacial
3 Actively Recruiting
Not Applicable, Early Phase 1
Postherpetic Neuralgia
0 Actively Recruiting
Irritable Bowel Syndrome (IBS)
9 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Pain
4 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1
Depression
198 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Chronic Pain
30 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Pamelor Reviews: What are patients saying about Pamelor?
5Patient Review
7/1/2013 While this drug did help with my depression and anxiety, the headaches it gave me were really severe. Aspirin helped a bit but then I started having stomach problems. constipation was also an unfortunate side effect.
4.7Patient Review
12/18/2013 I started taking this medication on Friday 12/15/13 and have since felt electrical shocks around my ankle. These shocks last for 5-10 seconds before stopping. I've had this feeling 4 times today and wonder if the drug is causing these side effects?
4.7Patient Review
7/21/20124Patient Review
1/30/2014 This medication does exactly what it says it will do, with no negative side effects that I can tell. However, it is very expensive. Generics don't seem to work as well.
4Patient Review
6/12/2014 Made me drowsy, but was otherwise effective.
3.7Patient Review
6/27/2014 Pamelor has been a game-changer for me, managing my TBI symptoms and mood swings. The negatives are that it's caused some hair loss and weight gain, but those effects have been manageable.
3.7Patient Review
1/23/2013 I'm not entirely sure what this is, but it seems to be working?
3.7Patient Review
7/29/2014 Unfortunately, this medication caused me some pretty uncomfortable muscle shakes - especially in my hands.
3Patient Review
11/19/2014 I had some trouble swallowing this medication.
2.7Patient Review
2/17/2014 I've been taking a small dose of this for over two years now. It helps to reduce my anxiety and also makes it easier for me to fall asleep at night.
1Patient Review
5/21/2015 Unfortunately, this medication made me so nauseated that I could only take it for a short time. Additionally, it left me feeling very anxious and "weird."
1Patient Review
12/24/2012 I didn't sleep at all while taking this drug and my heart rate was constantly high.
1Patient Review
9/25/2012 The dry mouth was the worst part, but other than that this drug was helpful.
Patient Q&A Section about pamelor
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is the drug Pamelor used for?
"This medication is used to treat depression. It may help improve mood, relieve anxiety, and increase energy levels."
Answered by AI
Is Pamelor a benzo?
"Pamelor and Xanax are two very different drugs that have some similarities in terms of side effects. Pamelor is a tricyclic antidepressant while Xanax is a benzodiazepine. Some of the side effects that these two drugs have in common include blurred vision, dry mouth, constipation, weight changes, dizziness, weakness, poor balance or coordination, nausea, and decreased sex drive."
Answered by AI
What type of drug is Pamelor?
"In chemistry, organic compounds are any chemical compounds that contain carbon-hydrogen or carbon-carbon bonds. Due to carbon's ability to catenate, there are millions of organic compounds known."
Answered by AI
What are the most common side effects of nortriptyline?
"The potential side effects of this medication include nausea, drowsiness, weakness or tiredness, excitement or anxiety, nightmares, dry mouth, changes in appetite or weight, and constipation."
Answered by AI