Norpace Cr

Ventricular Arrhythmia
Treatment
1 FDA approval
7 Active Studies for Norpace Cr

What is Norpace Cr

DisopyramideThe Generic name of this drug
Treatment SummaryProcainamide is a medication used to treat irregular heartbeats. It works by stabilizing the electrical signals in the heart, similar to the drug guanidine. It also has properties that help with muscle spasms and numbness.
Norpaceis the brand name
image of different drug pills on a surface
Norpace Cr Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Norpace
Disopyramide
1977
30

Approved as Treatment by the FDA

Disopyramide, otherwise known as Norpace, is approved by the FDA for 1 uses which include Ventricular Arrhythmia .
Ventricular Arrhythmia
Helps manage Ventricular Arrhythmia

Effectiveness

How Norpace Cr Affects PatientsDisopyramide is a drug used to treat serious heart rhythm problems. It helps to make the heart beat slower and more regularly. Disopyramide will also make areas of the heart's electrical system that control the heart rate longer, but does not have a significant effect on the other electrical pathways of the heart. However, it will cause some of the pathways to take longer to send signals.
How Norpace Cr works in the bodyDisopyramide is a type of drug used to treat irregular heart beats. It works by slowing down the electrical signals that cause your heart to beat. This drug has been shown to reduce the speed of diastolic depolarization and action potential duration in animal studies, as well as reduce the difference in refractoriness between damaged and healthy parts of the heart. Disopyramide does not affect the alpha- or beta-adrenergic receptors.

When to interrupt dosage

The prescribed amount of Norpace Cr is contingent upon the determined condition. The quantity of dosage is contingent upon the method of administration (e.g. Tablet, extended release - Oral or Oral) delineated in the table underneath.
Condition
Dosage
Administration
Ventricular Arrhythmia
, 100.0 mg, 150.0 mg, 250.0 mg
, Oral, Capsule, Capsule - Oral, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, extended release, Capsule, extended release - Oral

Warnings

Norpace Cr Contraindications
Condition
Risk Level
Notes
Prolonged QT interval
Do Not Combine
Shock, Cardiogenic
Do Not Combine
Atrioventricular Block
Do Not Combine
There are 20 known major drug interactions with Norpace Cr.
Common Norpace Cr Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Major
Disopyramide may increase the bradycardic activities of Acebutolol.
Aclidinium
Major
The risk or severity of adverse effects can be increased when Disopyramide is combined with Aclidinium.
Alprenolol
Major
Disopyramide may increase the bradycardic activities of Alprenolol.
Anisodamine
Major
Disopyramide may increase the bradycardic activities of Anisodamine.
Arotinolol
Major
Disopyramide may increase the bradycardic activities of Arotinolol.
Norpace Cr Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats has been found to be 580mg/kg.
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Norpace Cr Novel Uses: Which Conditions Have a Clinical Trial Featuring Norpace Cr?

At present, 4 active clinical trials are being conducted to assess the potential of Norpace Cr in managing Ventricular Arrhythmia.
Condition
Clinical Trials
Trial Phases
Ventricular Arrhythmia
7 Actively Recruiting
Not Applicable, Phase 3, Phase 4

Norpace Cr Reviews: What are patients saying about Norpace Cr?

5Patient Review
8/17/2009
Norpace Cr for Atrial Fibrillation Electrically Shocked to Normal Rhythm
NO COMMENT
5Patient Review
10/3/2011
Norpace Cr for Prevention of Recurrent Atrial Fibrillation
I'm glad this fourth medication I tried finally worked for my atrial fibrillation. I did have to be monitored in the hospital, but it was worth it to find a treatment that actually worked and didn't cause other issues like the Multaq I was on previously.
4.7Patient Review
7/5/2009
Norpace Cr for Heart Ventricle Rhythm Problem
4.3Patient Review
11/10/2010
Norpace Cr for Prevention of Recurrent Atrial Fibrillation
This treatment helps me stay in a normal heart rhythm, unless my potassium levels drop below 4.0.
3Patient Review
12/19/2009
Norpace Cr for Heart Ventricle Rhythm Problem
I take this medication along with Coreg twice a day. I haven't had any problems as long as I stick to the name brand; however, when I tried the generic version, I experienced breakthrough irregularity.
1.7Patient Review
9/25/2013
Norpace Cr for Heart Ventricle Rhythm Problem
My husband felt much better before taking this medication and told the doctor he would rather stop taking it because of the severe side effects. These included insomnia, a dry mouth and throat, constipation, and general discomfort. We stopped the medication immediately and found a different drug.
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Patient Q&A Section about norpace cr

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What class of drug is Norpace?

"Class Ia antiarrhythmic drugs work on the sodium channels in the heart. Disopyramide is one of these drugs. Other Class Ia antiarrhythmic drugs include procainamide and quinidine."

Answered by AI

Is Norpace CR available?

"The two strengths are available in a box of 30.

Pfizer has two strengths of Norpace CR 100 mg and 150 mg capsules available in a box of 30."

Answered by AI

What is Norpace CR used for?

"This medication is used to treat ventricular tachycardia, an irregular heartbeat that could be fatal. Disopyramide is an anti-arrhythmic drug that restores normal heart rhythm and maintains a regular, steady heartbeat."

Answered by AI

What is the difference between Norpace and Norpace CR?

"Norpace is a drug made of two isomers, d- and l-. It is not chemically related to other antiarrhythmic drugs. Norpace CR (controlled-release) capsules are designed to release disopyramide gradually and consistently."

Answered by AI

Clinical Trials for Norpace Cr

Image of Emory University Hospital in Atlanta, United States.

EDEN System for Ventricular Arrhythmia

21 - 100
All Sexes
Atlanta, GA
Background: Heart surgeons use electrocardiogram (ECG) machines to record electrical signals from the heart during procedures. Normal ECG machines connect only to the skin. Special ECG machines connect directly to the heart; they are a safer option during procedures. Researchers want to test a new ECG machine called the EDEN system. Objective: To test the EDEN system in people having heart procedures. The new system will be used along with an approved special ECG machine. Eligibility: People aged 21 years or older who need to have a heart procedure. These procedures can include (1) electrophysiology mapping or ablation; and (2) conduction system pacing. Design: Researchers will review participants' medical records. No extra tests are needed. Participants will have their heart procedure as planned. The EDEN system will be linked to the special ECG used during the procedure. An extra electrode may be placed on the participant's body. Electrodes are small stickers attached to wires that go to the machine. The EDEN system will record and analyze electrical signals already being measured. It will not interfere with participants' care. No medical decisions well be made based on its data. No follow-up visits are needed for this study....
Waitlist Available
Has No Placebo
Emory University HospitalRobert J Lederman, M.D.
Image of Keck Hospital of the University of Southern California in Los Angeles, United States.

Mitral Valve Repair Procedures for Mitral Valve Prolapse

18+
All Sexes
Los Angeles, CA
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological processes by which mitral valve prolapse (MVP) can impact left ventricular (LV) myocardial structure and function, and, thereby, predispose to arrhythmias and sudden death. Such insights are key to identifying interventions to reduce the long-term sequelae of heart failure (HF) and arrhythmias, as well as delineate optimal therapeutic approaches for different patient sub-groups.
Recruiting
Has No Placebo
Keck Hospital of the University of Southern California (+15 Sites)Martin Leon, MD
Image of HonorHealth in Scottsdale, United States.

Carvedilol vs Metoprolol for Heart Failure

18+
All Sexes
Scottsdale, AZ
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter defibrillator (ICD). The study will enroll 2,000 participants across 100 U.S. sites and includes an 18-month feasibility phase with 100 participants from 15 sites. Eligible participants must be currently treated with metoprolol succinate and willing to switch to carvedilol, with randomization in a 1:1 ratio. Participants will be followed for up to 3 years, with regular assessments including ICD interrogations, medication adherence, healthcare utilization, and quality of life surveys. The primary endpoint is the first occurrence of any ICD therapy (appropriate or inappropriate), cardiovascular (CV) hospitalization, or CV death. Secondary endpoints include ICD shock burden, healthcare utilization, and patient-reported quality of life. The trial aims to provide high-quality comparative data to address clinical equipoise surrounding the two commonly used beta-blockers in HFrEF management.
Phase 4
Recruiting
HonorHealth (+12 Sites)
Image of Emory University in Atlanta, United States.

VINTAGE Procedure for Ventricular Arrhythmia

21 - 100
All Sexes
Atlanta, GA
Background: Ventricular arrhythmia is an abnormal pulse rhythm that starts in the lower part of the heart (ventricles). Treatment includes ablation; ablation uses heat to destroy small portions of the heart that are causing short circuits in the normal heartbeats. But ablation does not always work well because some parts of the heart are hard to reach with current tools. Researchers want to try a new method called VINTAGE (ventricular intramyocardial navigation for tachycardia ablation guided by electrograms). VINTAGE may be better able to treat portions of the heart that are harder to reach with standard techniques. Objective: To test VINTAGE in people with ventricular arrhythmia. Eligibility: People aged 21 years and older with ventricular arrhythmia that did not respond to standard treatment. Design: Participants will have baseline tests. They will have blood tests and tests of their heart function. They will have imaging scans. They will complete a health questionnaire. Participants will undergo the VINTAGE procedure. They will be either completely or partially asleep. Doctors will insert tubes through large blood vessels in the groin. Tubes may also be inserted through the chest and wrist. They will use x-rays and ultrasound to guide tubes and guidewires directly into the heart muscle to do the ablation. Participants will stay in the hospital 1 or more nights after the procedure. Participants will have 3 follow-up visits over 6 months. These visits are for standard care after heart ablation. They will include blood tests, imaging scans, and tests of heart function. Participants may also wear a device to monitor their heart rhythms at home.
Waitlist Available
Has No Placebo
Emory UniversityRobert J Lederman, M.D.
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