Megace Es

metastatic Endometrial carcinoma, Recurrent Endometrial Carcinoma, Acquired Immunodeficiency Syndrome + 7 more
Treatment
20 Active Studies for Megace Es

What is Megace Es

Megestrol acetateThe Generic name of this drug
Treatment Summary17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione is a hormone used to treat various conditions. It is usually prescribed in the form of an acetate ester and is more powerful than progesterone. It is used to suppress ovulation and as a way to manage certain types of breast cancer.
Megestrol Acetateis the brand name
image of different drug pills on a surface
Megace Es Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Megestrol Acetate
Megestrol acetate
1988
76

Effectiveness

How Megace Es Affects PatientsMegestrol is a synthetic form of the hormone progesterone, which affects the endometrium, body temperature, and pituitary gland. It also has a small effect on glucocorticoid and mineralocorticoid hormones. This drug does not have any estrogenic, androgenic, or anabolic effects. The exact way it works to reduce appetite and cachexia (wasting) is unknown. It was originally developed as a contraceptive, but was later found to be useful in treating breast cancer.
How Megace Es works in the bodyWe don't know exactly how megestrol acetate works, but it likely has something to do with suppressing hormones that control appetite. It also seems to change how the body breaks down food, which may help explain why it causes weight gain. Megestrol may also interfere with hormones that prevent fat from being stored in the body.

When to interrupt dosage

The endorsed dosage of Megace Es relies upon the determined condition, including Recurrent Endometrial Carcinoma, Breast and Endometrial Carcinoma. The quantity of dosage fluctuates as per the method of delivery (e.g. Oral or Suspension - Oral) noted in the table beneath.
Condition
Dosage
Administration
Acquired Immunodeficiency Syndrome
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Endometrial Carcinoma
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Recurrent Endometrial Carcinoma
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Breast
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Breast
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
metastatic Endometrial carcinoma
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Palliative Treatment
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Weight decreased
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Breast
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral
Loss of Appetite
, 40.0 mg, 125.0 mg/mL, 40.0 mg/mL, 20.0 mg, 80.0 mg/mL, 160.0 mg, 625.0 mg/mL
, Tablet, Oral, Tablet - Oral, Suspension, Suspension - Oral

Warnings

Megace Es Contraindications
Condition
Risk Level
Notes
suspected pregnancy
Do Not Combine
There are 20 known major drug interactions with Megace Es.
Common Megace Es Drug Interactions
Drug Name
Risk Level
Description
Dofetilide
Major
Megestrol acetate may decrease the excretion rate of Dofetilide which could result in a higher serum level.
Tranexamic acid
Major
Megestrol acetate may increase the thrombogenic activities of Tranexamic acid.
Abacavir
Minor
Megestrol acetate may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetohexamide
Minor
The therapeutic efficacy of Acetohexamide can be decreased when used in combination with Megestrol acetate.
Aclidinium
Minor
Megestrol acetate may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Megace Es Toxicity & Overdose RiskStudies have not reported any serious side effects from taking megestrol acetate oral suspension in doses up to 1200 mg/day. Taking megestrol acetate, a drug that increases the appetite, can lead to suppression of the adrenal glands. This is thought to be due to the drug's effects on the body's cortisol production.
image of a doctor in a lab doing drug, clinical research

Megace Es Novel Uses: Which Conditions Have a Clinical Trial Featuring Megace Es?

315 active clinical trials are currently being conducted to assess the potential of Megace Es to reduce metastatic Endometrial Carcinoma, Cachexia and Breast Disease.
Condition
Clinical Trials
Trial Phases
metastatic Endometrial carcinoma
0 Actively Recruiting
Breast
0 Actively Recruiting
Weight decreased
0 Actively Recruiting
Breast
0 Actively Recruiting
Breast
0 Actively Recruiting
Acquired Immunodeficiency Syndrome
5 Actively Recruiting
Phase 2, Phase 3, Phase 1, Not Applicable
Palliative Treatment
0 Actively Recruiting
Endometrial Carcinoma
0 Actively Recruiting
Loss of Appetite
3 Actively Recruiting
Phase 1, Phase 2, Not Applicable
Recurrent Endometrial Carcinoma
14 Actively Recruiting
Phase 2, Phase 1, Phase 3

Megace Es Reviews: What are patients saying about Megace Es?

5Patient Review
2/15/2008
Megace Es for Loss of Appetite with HIV
This drug is extremely effective. If you're struggling to maintain weight, this will help you out. The only downside is that it can make it harder to sleep at night.
4.3Patient Review
9/16/2008
Megace Es for Decrease in Weight due to HIV Infection
I've been able to eat more since starting this treatment and I've already put on 15 pounds in less than two weeks.
4.3Patient Review
12/8/2008
Megace Es for Metastatic Endometrial Carcinoma
Magace has, as advertised, increased my appetite. I'm now eating more and have even put on some weight. However, it also comes with the side effect of seriously increasing gas production. Not sure if the extra appetite is worth that!
1Patient Review
4/18/2012
Megace Es for Cancer in the Lining of the Uterus
I've been taking Megace for nearly three weeks now to treat my endometrial cancer. I'm not sure if the side effects are worth the slim chance of it helping me cure my cancer. I've been experiencing extreme agitation, anxiety, inability to sleep at night, diarrhea, and increased appetite since starting this medication, which has lead to weight gain. I snap at everyone over EVERYTHING. I don't think this is going to work for me.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about megace es

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Megace Es

Have you considered Megace Es clinical trials? We made a collection of clinical trials featuring Megace Es, we think they might fit your search criteria.
Have you considered Megace Es clinical trials? We made a collection of clinical trials featuring Megace Es, we think they might fit your search criteria.
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