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What is Lumify
BrimonidineThe Generic name of this drug
Treatment SummaryBrimonidine is a medication used to treat glaucoma, which is a common cause of blindness. It helps reduce the pressure in the eye by decreasing the production of fluid and increasing the drainage of fluid. It is a safer alternative to other glaucoma medications as it has fewer side effects and is less likely to cause ocular allergic reactions. Brimonidine is also used to treat persistent facial redness in adults caused by rosacea. It is sold under the brand name Mirvaso and was approved by the FDA in 2013.
Alphagan Pis the brand name
Lumify Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Alphagan P
Brimonidine
2001
43
Approved as Treatment by the FDA
Brimonidine, commonly known as Alphagan P, is approved by the FDA for 3 uses including Increased Intra Ocular Pressure (IOP) and Open Angle Glaucoma .Increased Intra Ocular Pressure (IOP)
Helps manage Increased Intra Ocular Pressure (IOP)
Open Angle Glaucoma
Helps manage Open Angle Glaucoma (OAG)
Ocular Hypertension
Helps manage Ocular Hypertension
Effectiveness
How Lumify Affects PatientsBrimonidine is a drug that is much more likely to affect alpha-2 adrenergic receptors than alpha-1 adrenergic receptors, which helps reduce the risk of side effects like low blood pressure, slow heart rate, and sedation. It is known to lower eye pressure, and has been used in clinical studies to reduce redness in those with rosacea. When taken systemically, brimonidine can cause a drop in blood pressure, slower heart rate, and changes to the heart rhythm. It has been suggested that it may help protect the nerves in the eyes and brain from damage, but more research is needed to confirm this
How Lumify works in the bodyBrimonidine works by activating alpha-2 adrenoceptors in the eye, which leads to a reduction in norpinephrine (NE) release, decreasing the stimulation of beta-2 adrenoceptors, and reducing the production of aqueous humour. This helps to lower intraocular pressure (IOP), which is the leading cause of glaucoma. In addition, brimonidine can be used topically on the skin to reduce redness and swelling by constricting small arteries and veins. This makes it an effective treatment for facial erythema of rosacea.
When to interrupt dosage
The suggested quantity of Lumify is contingent upon the diagnosed disorder, for example Open Angle Glaucoma, facial erythema and Ocular Hypertension. The measure of dosage deviates as per the procedure of delivery delineated in the table below.Condition
Dosage
Administration
Open-angle glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Rosacea
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Open Angle Glaucoma
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Ocular Hypertension
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
facial erythema
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
inadequately controlled intraocular pressure
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Increased Intra Ocular Pressure (IOP)
, 1.5 mg/mL, 1.0 mg/mL, 2.0 mg/mL, 2.0 mg/mg, 0.2 %, 0.15 %, 0.33 %, 0.003 mg/mg, 0.005 mg/mg, 0.25 mg/mL, 0.0025 mg/mg, 0.025 %
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Suspension / drops, Suspension / drops - Ophthalmic, Solution, Solution - Ophthalmic, Liquid, Liquid - Ophthalmic, Topical, Gel, Gel - Topical, Cutaneous, Gel - Cutaneous, Suspension - Ophthalmic, Suspension
Warnings
Lumify ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Brimonidine may interact with Pulse Frequency
Common Lumify Drug Interactions
Drug Name
Risk Level
Description
Oliceridine
Major
The risk or severity of hypotension, sedation, death, somnolence, and respiratory depression can be increased when Brimonidine is combined with Oliceridine.
Acebutolol
Minor
Brimonidine may increase the antihypertensive activities of Acebutolol.
Aliskiren
Minor
Brimonidine may increase the antihypertensive activities of Aliskiren.
Alprenolol
Minor
Brimonidine may increase the antihypertensive activities of Alprenolol.
Ambrisentan
Minor
Brimonidine may increase the antihypertensive activities of Ambrisentan.
Lumify Toxicity & Overdose Risk**Lowest Toxic Dose and Overdose**In mice, the lowest toxic dose of brimonidine is 50mg/kg and in rats it is 100mg/kg. People who overdose on brimonidine may experience low blood pressure, exhaustion, vomiting, drowsiness, slow heartbeat, abnormal heart rhythms, pinpoint pupils, breathing difficulties, low body temperature, and seizures. Treatment for brimonidine overdose includes supportive care and symptom relief. Accidental overdose in infants and young children has been reported, with symptoms like those seen in adults. **Nonclinical Toxicology**Brimon
Lumify Novel Uses: Which Conditions Have a Clinical Trial Featuring Lumify?
114 active clinical trials are in progress to explore the possible benefits of Lumify in managing Open Angle Glaucoma, inadequately controlled intraocular pressure and Open Angle Glaucoma.Condition
Clinical Trials
Trial Phases
Open-angle glaucoma
84 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1
Rosacea
0 Actively Recruiting
Ocular Hypertension
22 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4
Open Angle Glaucoma
12 Actively Recruiting
Not Applicable, Phase 3, Phase 2
inadequately controlled intraocular pressure
0 Actively Recruiting
facial erythema
0 Actively Recruiting
Increased Intra Ocular Pressure (IOP)
0 Actively Recruiting
Lumify Reviews: What are patients saying about Lumify?
5Patient Review
8/25/2022 Lumify is, without a doubt, the best option for removing redness from your eyes. It works very quickly and is much more effective than Visene. I have chronically red eyes due to wearing contacts for too long when I was younger, and this drop has been a lifesaver in terms of making my eyes look white and healthy again.
4Patient Review
2/28/2022 Lumify is not a lubricating eye drop, but it helped me with my red eyes and the scratchy feeling I get from dry eye syndrome. I followed the directions and waited 5 minutes before applying another type of eye drop, and it worked great!
2.3Patient Review
8/12/2020 On the third application of Lumify, I started seeing jagged lines of light. It was really strange and scared me because it was in both eyes. Thankfully, it stopped after a couple minutes.
2Patient Review
7/31/2022 Lumify did reduce the redness in my eyes, but it made them feel so uncomfortable that it wasn't worth it. Upneeq has been much better for me; not only is it more comfortable, but it also makes my eyes ridiculously white and improves my vision.
2Patient Review
8/19/2022 I found that Lumify did brighten my eyes, but the side effects were pretty severe. After only two days of using the drops as directed, my eyes felt very gritty and red. I stopped taking them immediately and hope that my eyes will go back to normal soon.
1Patient Review
10/13/2022 Do not use these eye drops. Will make your eyes more red and dependent on them. I felt like I was going blind by the end of the work day, could barely see the computer. Got an eye exam and have to get glasses progressives, now I have cataracts at 42.
Patient Q&A Section about lumify
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Who should not use LUMIFY?
"If you notice that the color of the solution has changed or it has become cloudy, do not use it. Also, tell your doctor if your condition does not improve within 3 days or if it gets worse."
Answered by AI
What exactly does LUMIFY do?
""
LUMIFY eye drops are designed to specifically reduce redness due to minor eye irritations, while also reducing the risks of rebound hyperemia, dependency, or tachyphylaxis—conditions that could lead to serious or permanent damage to the eye."
Answered by AI
How is LUMIFY different than Visine?
"The key difference between the way Visine and Lumify work is that Visine targets a receptor in the eye's arteries while Lumify acts on a receptor in the veins. Arteries carry oxygen-rich blood to the eye while veins take blood away from the eye."
Answered by AI
Is LUMIFY good for your eyes?
"Lumify is a lower concentration of Alphagan, a medication for glaucoma that has been around for a while. Lumify decreases pressure on the optic nerve by constricting blood vessels. Dr.Jul says that Lumify is safe because the dose is only a fraction of what is used for glaucoma."
Answered by AI