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What is Lozol
IndapamideThe Generic name of this drug
Treatment SummaryIndapamide is a diuretic medication used to treat high blood pressure (hypertension). It is one of the most commonly prescribed medications for this condition, coming in second after ACE inhibitors. When compared to other diuretics, indapamide has been found to be more effective at reducing systolic blood pressure and can also reduce other risk factors associated with cardiovascular disease. Unlike other diuretics, indapamide does not have any negative effects on glucose or lipids. This medication belongs to a class of drugs known as thiazide-like diuretics and is composed of two chemical groups: methylindoline and
Lozolis the brand name
Lozol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lozol
Indapamide
1983
36
Approved as Treatment by the FDA
Indapamide, also known as Lozol, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Used in combination with Hydrochlorothiazide / Losartan to help manage High Blood Pressure (Hypertension)
Effectiveness
How Lozol Affects PatientsIndapamide is a type of diuretic drug used to treat high blood pressure. Taking indapamide can lead to water and electrolyte loss, which can cause serious issues like an abnormal heartbeat (QTc prolongation). It can also cause imbalances in sodium, chloride, and magnesium levels. Indapamide can increase plasma renin and aldosterone levels and reduce calcium in the urine. Studies have found that it does not usually affect glucose tolerance in non-diabetic patients, but more research is needed to understand the long-term effects it may have on blood sugar levels.
How Lozol works in the bodyIndapamide works by inhibiting a transporter in the nephron, which helps the body hold onto less sodium and water. This reduces the amount of fluid in your body and lowers your blood pressure. It's thought that indapamide can also lower blood pressure by making your blood vessels more relaxed and not as responsive to agents that can cause your blood pressure to rise. More research is needed to fully understand how indapamide lowers blood pressure.
When to interrupt dosage
The amount of Lozol is contingent upon the specified condition, including Hypertensive disease, Congestive Heart Failure and recurrent Nephrolithiasis. The degree of dosage changes, depending upon the technique of delivery (e.g. Oral or Tablet - Oral) laid out in the table beneath.Condition
Dosage
Administration
sodium and fluid retention
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
recurrent Nephrolithiasis
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Lozol has three contraindications and should not be used when one is suffering from the conditions in the following table.Lozol ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Indapamide may interact with Pulse Frequency
Anuria
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Indapamide may interact with Pulse Frequency
Common Lozol Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Indapamide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Indapamide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Indapamide is combined with Dofetilide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Indapamide is combined with Hydroxyzine.
Methotrexate
Major
The risk or severity of adverse effects can be increased when Indapamide is combined with Methotrexate.
Lozol Toxicity & Overdose RiskSigns of indapamide overdose may include nausea, vomiting, stomach problems, abnormal levels of electrolytes, and feeling weak. Severe low blood pressure and difficulty breathing can also occur. If a person has overdosed on indapamide, treatment may involve inducing vomiting and washing out the stomach. Careful monitoring of electrolyte and fluid levels is important.
Lozol Novel Uses: Which Conditions Have a Clinical Trial Featuring Lozol?
43 active studies are currently examining the potential of Lozol to reduce Hypertensive Disease, Sodium and Fluid Retention, and recurrent Nephrolithiasis.Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
24 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
recurrent Nephrolithiasis
0 Actively Recruiting
sodium and fluid retention
0 Actively Recruiting
Lozol Reviews: What are patients saying about Lozol?
5Patient Review
11/24/2012 Although I have a sulfa allergy, this drug was still able to help me lower my blood pressure when other medications failed. I only lost 10 pounds and it helped me reduce or eliminate other drugs I was taking.
5Patient Review
3/21/2012 I'm a 55 year old male who's been taking Indapamide for 3-4 months now. The drop in my blood pressure was pretty significant and I haven't had any issues with side effects. I'm very pleased and wish I'd been prescribed this medication much sooner.
5Patient Review
11/20/2013 I've been taking this medication for a week now, and my blood pressure readings have improved significantly. I wish I had started taking it sooner!
5Patient Review
11/24/2012 Despite having a sulfa allergy, this diuretic was added when my blood pressure remained high. With only 10 pounds of weight loss and the addition of this drug, I have been able to reduce or eliminate other medications.
5Patient Review
3/21/2012 I'm a 55 year old man who's been taking Indapamide for 3-4 months now. My blood pressure has dropped dramatically since I began and I haven't experienced any negative side effects. I wish I had been prescribed this sooner!
5Patient Review
11/20/2013 It's been a week since I started taking this medication, and my blood pressure readings are the best they've been in a decade. I only wish I had started sooner!
4.7Patient Review
5/30/2016 I've been using this medication for six months and, on the whole, it's going well. Recently though, I started getting headaches. Not sure if it's the medicine or allergies; will have to keep an eye on it.
4.7Patient Review
5/30/2016 I've been on the medication for six months and, overall, it's been great. The only downside is that I started getting headaches. I'm not sure if it's the medicine or allergies, but I'll keep taking it for now.
4Patient Review
6/1/2017 I've only been on this medication for a little over a week, but it has already lowered my blood pressure into the normal range. I am experiencing some fatigue and muscle aches, but I'm hoping those side effects will go away soon. So far, I'm really happy with this treatment and how well it's working.
4Patient Review
9/8/2011 I was prescribed 5mg, but I felt unwell at that dosage. So, I dropped down to 2.5mg and have been feeling much better. My blood pressure has gone down, but my blood sugar has gone up; as a result, I am being more mindful of what I eat and trying to get some exercise in. Prior to this medication, I had swelling in my legs from standing for long periods of time on the job--but that's resolved itself now too.
4Patient Review
9/8/2011 I was originally prescribed 5mg, but I found that this made me feel ill. 2.5mg works much better for me. My blood pressure has gone down, but my blood sugar has increased; as a result, I am watching my diet more closely and eating more fruits. I was also experiencing edema in my legs, but because of the nature of my job (standing for long periods of time), it is not really possible to address that issue.
4Patient Review
6/1/2017 I have been on this medication for just over a week and it has already had an impact on my resistant high blood pressure. My blood pressure dropped to normal range quite instantly, which was surprising. However, I am dog tired and my muscles ache so I can't lift my arms/legs very easily. I am hoping these side effects wear off soon because after 9 months of searching, I am happy to finally find a treatment that works.
3.7Patient Review
5/21/2018 I had a seizure after about six weeks of taking this medication. I've never had one before and now doctors are trying to figure out if this is the cause. Still, I don't feel well overall and have developed new pains in my head and shoulders.
3.7Patient Review
5/21/2018 I had a seizure after taking this medication for six weeks. I've never had one before and now doctors are investigating whether or not this is the cause. I still don't feel great even after stopping the medication, with pains in my head and shoulders.
3.3Patient Review
7/30/2016 I've been taking this medication for a little over a week now. While it has helped with my leg and back pain, unfortunately it hasn't done much for my blood pressure. Additionally, the medicine has made it difficult to walk, so I'm not sure if continuing treatment is the best option at this time.
3.3Patient Review
6/1/2016 Recently, I've been experiencing swelling in my legs and feet, mostly at night. Not sure if it's related to my medication or not, but have noticed others having similar symptoms.
3.3Patient Review
6/1/2016 Recently, I've been dealing with annoying evening swelling in both of my legs, ankles and feet. Not sure if it's related to my medication or not, but I have noticed others having similar symptoms.
3.3Patient Review
7/30/2016 After a week of taking this medication, I found that my leg and back pain increased, especially at night. It also didn't do much to help lower my blood pressure. I'm not sure if I will continue taking it because the side effects are making it difficult for me to walk.
3Patient Review
6/12/2014 I had a serious reaction after two weeks of taking this drug, which resulted in me being hospitalized for six days. I'm now back home, but my life has been significantly impacted by this experience.
3Patient Review
2/4/2011 This drug is great. It really helped me.
3Patient Review
6/12/2014 At two weeks in, I had a seizure that lasted seven minutes. This caused me to spend six days on a saline drip to correct the Hyponatremia. Because I was in Turkey at the time, I couldn't communicate and ended up being medivaced home. As a result of this whole ordeal, I am now license-less and unable to continue teaching driving.
3Patient Review
2/4/2011 This drug is great. I'm grateful for modern medicine.
2.7Patient Review
8/1/2014 I've been taking Indapamide for half a year now, and it hasn't done much to help regulate my blood pressure. In fact, my A1c level has increased since I started taking this medication. So if you're considering this drug, definitely keep an eye on your sugar levels.
2.7Patient Review
8/1/2014 I have been taking Indapamide 2.5mg for 6 months. It has not regulated my BP to normal and after getting my 6 month blood test done my A1c went from 5.7 to 6.5. If you take this drug, keep an eye on your blood sugar levels as it may have negative impacts.
2.3Patient Review
4/5/2015 I'm currently dealing with a lot of pain and swelling in my foot that has now started to move up my leg. It's become very difficult to walk or stand.
2.3Patient Review
4/5/2015 The pain and swelling in my foot has gotten so bad that I can't even put weight on it. The swelling is now moving up my leg.
2Patient Review
7/10/2012 After a week of taking this medication, I have lost my appetite and can't sleep at night due to agonizing leg pains.
2Patient Review
7/10/2012 Unfortunately, I haven't had a good experience with this treatment. One week in and I'm struggling with nausea and lack of appetite, as well as bad leg pains that are keeping me up at night.
1.7Patient Review
10/14/2011 My wife was given indapamide as a diuretic to help with high blood pressure. However, it ended up causing more problems than it solved. She slowed down on urination and after a week her kidneys stopped working altogether. As a result, she spent a week in the hospital and is now on coumadin for 5 months.
1.7Patient Review
10/14/2011 My wife was given indapamide as a diuretic to help with her high blood pressure. Unfortunately, it had the opposite effect and actually stopped her kidneys from functioning properly. She ended up in the hospital for a week as a result and has been on coumadin for five months now.
1Patient Review
9/12/2022 I had some pretty unpleasant side effects when I first started this medication, but they thankfully subsided after a week.
1Patient Review
9/12/2022 I had some very unpleasant side effects for the first week of taking this medication, including nausea and dizziness. On the seventh day, I almost fainted. My doctor said that it might have been because the medication was too effective and caused my blood pressure to drop, but my readings were still within a normal range (albeit on the high end).
Patient Q&A Section about lozol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of lozol?
"Dizziness, weakness, and tiredness are some of the possible symptoms of back pain. Other symptoms include muscle cramps, feeling anxious or agitated, headache, or runny nose."
Answered by AI
What is the drug indapamide used for?
"Indapamide is used to lower high blood pressure. It may be used alone or with other blood pressure lowering medicines. High blood pressure makes the heart work harder and can damage the blood vessels. Over time, this can lead to heart disease, stroke, kidney problems, and other health problems."
Answered by AI
Is lozol a thiazide?
"Lozol is an oral antihypertensive/diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. It does not have a thiazide ring system and only contains one sulfonamide group."
Answered by AI
What is lozol prescribed for?
"Indapamide is a medication used to lower blood pressure and reduce edema, or excess fluid in the body, caused by heart failure. High blood pressure often leads to serious health complications such as strokes, heart attacks, and kidney problems, so lowering it with medication can help prevent these issues."
Answered by AI