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What is Lozol
IndapamideThe Generic name of this drug
Treatment SummaryIndapamide is a diuretic medication used to treat high blood pressure (hypertension). It is one of the most commonly prescribed medications for this condition, coming in second after ACE inhibitors. When compared to other diuretics, indapamide has been found to be more effective at reducing systolic blood pressure and can also reduce other risk factors associated with cardiovascular disease. Unlike other diuretics, indapamide does not have any negative effects on glucose or lipids. This medication belongs to a class of drugs known as thiazide-like diuretics and is composed of two chemical groups: methylindoline and
Lozolis the brand name
Lozol Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lozol
Indapamide
1983
36
Approved as Treatment by the FDA
Indapamide, also known as Lozol, is approved by the FDA for 1 uses including Hypertensive disease .Hypertensive disease
Used in combination with Hydrochlorothiazide / Losartan to help manage High Blood Pressure (Hypertension)
Effectiveness
How Lozol Affects PatientsIndapamide is a type of diuretic drug used to treat high blood pressure. Taking indapamide can lead to water and electrolyte loss, which can cause serious issues like an abnormal heartbeat (QTc prolongation). It can also cause imbalances in sodium, chloride, and magnesium levels. Indapamide can increase plasma renin and aldosterone levels and reduce calcium in the urine. Studies have found that it does not usually affect glucose tolerance in non-diabetic patients, but more research is needed to understand the long-term effects it may have on blood sugar levels.
How Lozol works in the bodyIndapamide works by inhibiting a transporter in the nephron, which helps the body hold onto less sodium and water. This reduces the amount of fluid in your body and lowers your blood pressure. It's thought that indapamide can also lower blood pressure by making your blood vessels more relaxed and not as responsive to agents that can cause your blood pressure to rise. More research is needed to fully understand how indapamide lowers blood pressure.
When to interrupt dosage
The amount of Lozol is contingent upon the specified condition, including Hypertensive disease, Congestive Heart Failure and recurrent Nephrolithiasis. The degree of dosage changes, depending upon the technique of delivery (e.g. Oral or Tablet - Oral) laid out in the table beneath.Condition
Dosage
Administration
Kidney Calculi
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Hypertensive disease
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Congestive Heart Failure
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Edema
, 1.25 mg, 2.5 mg, 0.625 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Lozol has three contraindications and should not be used when one is suffering from the conditions in the following table.Lozol ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Indapamide may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Indapamide may interact with Pulse Frequency
Anuria
Do Not Combine
Common Lozol Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Indapamide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Indapamide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Indapamide is combined with Dofetilide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Indapamide is combined with Hydroxyzine.
Methotrexate
Major
The risk or severity of adverse effects can be increased when Indapamide is combined with Methotrexate.
Lozol Toxicity & Overdose RiskSigns of indapamide overdose may include nausea, vomiting, stomach problems, abnormal levels of electrolytes, and feeling weak. Severe low blood pressure and difficulty breathing can also occur. If a person has overdosed on indapamide, treatment may involve inducing vomiting and washing out the stomach. Careful monitoring of electrolyte and fluid levels is important.
Lozol Novel Uses: Which Conditions Have a Clinical Trial Featuring Lozol?
43 active studies are currently examining the potential of Lozol to reduce Hypertensive Disease, Sodium and Fluid Retention, and recurrent Nephrolithiasis.Condition
Clinical Trials
Trial Phases
Kidney Calculi
0 Actively Recruiting
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Hypertensive disease
23 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Edema
0 Actively Recruiting
Lozol Reviews: What are patients saying about Lozol?
5Patient Review
11/24/2012 Although I have a sulfa allergy, this drug was still able to help me lower my blood pressure when other medications failed. I only lost 10 pounds and it helped me reduce or eliminate other drugs I was taking.
5Patient Review
3/21/2012 I'm a 55 year old male who's been taking Indapamide for 3-4 months now. The drop in my blood pressure was pretty significant and I haven't had any issues with side effects. I'm very pleased and wish I'd been prescribed this medication much sooner.
5Patient Review
11/20/2013 I've been taking this medication for a week now, and my blood pressure readings have improved significantly. I wish I had started taking it sooner!
5Patient Review
11/24/2012 Despite having a sulfa allergy, this diuretic was added when my blood pressure remained high. With only 10 pounds of weight loss and the addition of this drug, I have been able to reduce or eliminate other medications.
5Patient Review
3/21/2012 I'm a 55 year old man who's been taking Indapamide for 3-4 months now. My blood pressure has dropped dramatically since I began and I haven't experienced any negative side effects. I wish I had been prescribed this sooner!
Patient Q&A Section about lozol
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What are the side effects of lozol?
"Dizziness, weakness, and tiredness are some of the possible symptoms of back pain. Other symptoms include muscle cramps, feeling anxious or agitated, headache, or runny nose."
Answered by AI
What is the drug indapamide used for?
"Indapamide is used to lower high blood pressure. It may be used alone or with other blood pressure lowering medicines. High blood pressure makes the heart work harder and can damage the blood vessels. Over time, this can lead to heart disease, stroke, kidney problems, and other health problems."
Answered by AI
Is lozol a thiazide?
"Lozol is an oral antihypertensive/diuretic. It contains both a polar sulfamoyl chlorobenzamide moiety and a lipid-soluble methylindoline moiety. It does not have a thiazide ring system and only contains one sulfonamide group."
Answered by AI
What is lozol prescribed for?
"Indapamide is a medication used to lower blood pressure and reduce edema, or excess fluid in the body, caused by heart failure. High blood pressure often leads to serious health complications such as strokes, heart attacks, and kidney problems, so lowering it with medication can help prevent these issues."
Answered by AI
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