Your session is about to expire
What is Lomotil
DiphenoxylateThe Generic name of this drug
Treatment SummaryDiphenoxylate is a medication used to treat diarrhea, usually in combination with atropine. It has a similar effect to morphine but does not have the same pain-relieving properties. It is classified as a Schedule V drug by the FDA and DEA when used in combination, and a Schedule II drug when used alone.
Lomotilis the brand name
Lomotil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lomotil
Diphenoxylate
1960
91
Approved as Treatment by the FDA
Diphenoxylate, commonly known as Lomotil, is approved by the FDA for 1 uses including Gastroenteritis .Gastroenteritis
Used to treat Diarrhea in combination with Atropine
Effectiveness
How Lomotil Affects PatientsDiphenoxylate is a drug used to help reduce diarrhea. When taken, it is quickly changed by the body into diphenoxylic acid (difenoxine), which is active and found in the blood.
How Lomotil works in the bodyDiphenoxylate works by activating mu receptors in the gastrointestinal tract. This results in decreased muscle movement, which slows down transit time in the digestive system. The contact between food and the intestine is also increased, leading to the drug's antidiarrheal effects.
When to interrupt dosage
The proposed dose of Lomotil is dependent upon the identified condition. The quantity of dosage can be seen in the provided table, in line with the mode of delivery (e.g. Solution or Liquid - Oral).Condition
Dosage
Administration
Gastroenteritis
2.5 mg, , 2.5 mg/mL
, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral
Warnings
Lomotil ContraindicationsCondition
Risk Level
Notes
Jaundice, Obstructive
Do Not Combine
Pseudomembranous Enterocolitis, enterotoxin-producing bacteria
Do Not Combine
Common Lomotil Drug Interactions
Drug Name
Risk Level
Description
Azelastine
Major
Diphenoxylate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Eluxadoline
Major
The risk or severity of constipation can be increased when Diphenoxylate is combined with Eluxadoline.
Ethanol
Major
Diphenoxylate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.
Methylene blue
Major
Diphenoxylate may increase the serotonergic activities of Methylene blue.
Mirtazapine
Major
Diphenoxylate may increase the serotonergic activities of Mirtazapine.
Lomotil Toxicity & Overdose RiskOverdosing on a drug can lead to a coma, dry, flushed skin, large pupils, a high temperature, involuntary eye movements, weak muscles, very small pupils, a fast heartbeat, restlessness, tiredness, and shallow breathing.
Lomotil Novel Uses: Which Conditions Have a Clinical Trial Featuring Lomotil?
31 active clinical trials are evaluating the effectiveness of Lomotil in managing Gastroenteritis.Condition
Clinical Trials
Trial Phases
Gastroenteritis
26 Actively Recruiting
Phase 1, Phase 2, Phase 4, Phase 3, Not Applicable
Lomotil Reviews: What are patients saying about Lomotil?
5Patient Review
4/29/2017 I was struggling for days before trying this medication. I saw the doctor, who gave me a shot of Phenegan 25mg in addition to the medication. Within 10 hours, I felt great again.
5Patient Review
4/21/2016 I've been using this treatment for five years now and it has never let me down.
5Patient Review
7/25/2016 I've been taking Lomotil for seven years now, ever since my colon was removed due to ulcerative colitis. When I first started taking it, it worked great— but now, even after increasing the dosage (I take four pills three times a day), it barely does anything.
5Patient Review
11/27/2016 Since having my gall bladder removed, I've struggled with urgent bowel movements. This medication offers quick and effective relief within 15 minutes.
5Patient Review
8/8/2021 It's effective with minimal side-effects. The main one being drowsiness, which for me also translated into feeling sleepy.
5Patient Review
12/17/20145Patient Review
1/16/2016 This medication is really effective for me. I only need to take two pills before an event, and it prevents any embarrassing accidents.
5Patient Review
10/18/2015 This medication always works quickly and effectively for me to stop my diarrhea.
5Patient Review
9/8/2017 I've found that two tablets of this medication are effective the first time, rather than just one.
4.3Patient Review
3/27/2015 This medication works very quickly to stop my chemotherapy-induced diarrhea. Additionally, it provides relief from other chemo side effects like nausea, headaches, dizziness, and lightheadedness. It's been a miracle for me.
4.3Patient Review
7/4/2015 I think I'm allergic to this medication. I've got blisters on my tongue and gums, and they're both hurting really badly. If anyone else has had a similar experience, please let me know.
4.3Patient Review
12/18/2018 I'm so glad I had this medication when I got food poisoning in Mexico.
4Patient Review
3/21/20152.3Patient Review
10/27/20142Patient Review
5/22/2016 I had some bad stomach upset which was quickly resolved with Lomotil.
1Patient Review
4/5/2019 This medication helped to stop my diarrhea, but it also made me incredibly drowsy.
Patient Q&A Section about lomotil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Why is Lomotil a narcotic?
"Lomotil (diphenoxylate / atropine) is a controlled medication, because it contains diphenoxylate, which is an opioid medication."
Answered by AI
How long does it take Lomotil to stop diarrhea?
"After that, reduce your dosage to two tablets three times a day, then two tablets twice a day, until you finish the medication.
When you start using Lomotil, your doctor will prescribe two tablets four times a day. The maximum recommended dosage is eight tablets (20 mg of diphenoxylate) a day. Within 48 hours, the dosage should be reduced to two tablets three times a day, then two tablets twice a day, until you finish the medication."
Answered by AI
What is Lomotil used for?
"This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the movement of the intestine."
Answered by AI
Are Lomotil and Imodium the same thing?
"Lomotil and Imodium are not the same, although they work in similar ways. Lomotil can only be obtained with a prescription, while Imodium can be purchased over the counter."
Answered by AI