Lomotil

Gastroenteritis

Treatment

2 FDA approvals

12 Active Studies for Lomotil

Treatment for

Gastroenteritis

What is Lomotil

DiphenoxylateThe Generic name of this drug

Treatment SummaryDiphenoxylate is a medication used to treat diarrhea, usually in combination with atropine. It has a similar effect to morphine but does not have the same pain-relieving properties. It is classified as a Schedule V drug by the FDA and DEA when used in combination, and a Schedule II drug when used alone.

Lomotilis the brand name

image of different drug pills on a surface

Lomotil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Lomotil

Diphenoxylate

1960

Approved as Treatment by the FDA

Diphenoxylate, commonly known as Lomotil, is approved by the FDA for 2 uses including Diarrhea and Gastroenteritis .

Diarrhea

Used to treat Diarrhea in combination with Atropine

Gastroenteritis

Used to treat Diarrhea in combination with Atropine

Effectiveness

How Lomotil Affects PatientsDiphenoxylate is a drug used to help reduce diarrhea. When taken, it is quickly changed by the body into diphenoxylic acid (difenoxine), which is active and found in the blood.

How Lomotil works in the bodyDiphenoxylate works by activating mu receptors in the gastrointestinal tract. This results in decreased muscle movement, which slows down transit time in the digestive system. The contact between food and the intestine is also increased, leading to the drug's antidiarrheal effects.

When to interrupt dosage

The proposed dose of Lomotil is dependent upon the identified condition. The quantity of dosage can be seen in the provided table, in line with the mode of delivery (e.g. Solution or Liquid - Oral).

Condition

Dosage

Administration

Gastroenteritis

2.5 mg, , 2.5 mg/mL

, Oral, Tablet, Tablet - Oral, Solution, Solution - Oral, Liquid, Liquid - Oral

Warnings

Lomotil Contraindications

Condition

Risk Level

Notes

Jaundice, Obstructive

Do Not Combine

Enterocolitis, Pseudomembranous

Do Not Combine

There are 20 known major drug interactions with Lomotil.

Common Lomotil Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Diphenoxylate may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Diphenoxylate is combined with Eluxadoline.

Ethanol

Major

Diphenoxylate may increase the central nervous system depressant (CNS depressant) activities of Ethanol.

Methylene blue

Major

Diphenoxylate may increase the serotonergic activities of Methylene blue.

Mirtazapine

Major

Diphenoxylate may increase the serotonergic activities of Mirtazapine.

Lomotil Toxicity & Overdose RiskOverdosing on a drug can lead to a coma, dry, flushed skin, large pupils, a high temperature, involuntary eye movements, weak muscles, very small pupils, a fast heartbeat, restlessness, tiredness, and shallow breathing.

image of a doctor in a lab doing drug, clinical research

Lomotil Novel Uses: Which Conditions Have a Clinical Trial Featuring Lomotil?

31 active clinical trials are evaluating the effectiveness of Lomotil in managing Gastroenteritis.

Condition

Clinical Trials

Trial Phases

Gastroenteritis

12 Actively Recruiting

Phase 2, Phase 1, Not Applicable, Early Phase 1

Lomotil Reviews: What are patients saying about Lomotil?

5Patient Review

4/29/2017

Lomotil for Diarrhea

I was struggling for days before trying this medication. I saw the doctor, who gave me a shot of Phenegan 25mg in addition to the medication. Within 10 hours, I felt great again.

5Patient Review

4/21/2016

Lomotil for Diarrhea

I've been using this treatment for five years now and it has never let me down.

5Patient Review

7/25/2016

Lomotil for Diarrhea

I've been taking Lomotil for seven years now, ever since my colon was removed due to ulcerative colitis. When I first started taking it, it worked great— but now, even after increasing the dosage (I take four pills three times a day), it barely does anything.

5Patient Review

11/27/2016

Lomotil for Diarrhea

Since having my gall bladder removed, I've struggled with urgent bowel movements. This medication offers quick and effective relief within 15 minutes.

5Patient Review

8/8/2021

Lomotil for high-output ileostomy

It's effective with minimal side-effects. The main one being drowsiness, which for me also translated into feeling sleepy.

View All Reviews

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Patient Q&A Section about lomotil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Why is Lomotil a narcotic?

"Lomotil (diphenoxylate / atropine) is a controlled medication, because it contains diphenoxylate, which is an opioid medication."

Answered by AI

How long does it take Lomotil to stop diarrhea?

"After that, reduce your dosage to two tablets three times a day, then two tablets twice a day, until you finish the medication.

When you start using Lomotil, your doctor will prescribe two tablets four times a day. The maximum recommended dosage is eight tablets (20 mg of diphenoxylate) a day. Within 48 hours, the dosage should be reduced to two tablets three times a day, then two tablets twice a day, until you finish the medication."

Answered by AI

What is Lomotil used for?

"This medication is used to treat diarrhea. It helps to decrease the number and frequency of bowel movements. It works by slowing the movement of the intestines. Diphenoxylate is similar to opioid pain relievers, but it acts mainly to slow the movement of the intestine."

Answered by AI

Are Lomotil and Imodium the same thing?

"Lomotil and Imodium are not the same, although they work in similar ways. Lomotil can only be obtained with a prescription, while Imodium can be purchased over the counter."

Answered by AI