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What is Galantamine Hydrobromide
GalantamineThe Generic name of this drug
Treatment SummaryGalantamine is a medication used to treat mild to moderate Alzheimer’s disease. It works by blocking an enzyme in the brain that breaks down acetylcholine, a chemical that helps send messages between nerve cells. This increases the amount of acetylcholine in the brain, which may improve thinking and memory. Galantamine is marketed under the brand name Razadyne and comes in oral tablets and a solution. It is not a cure and does not stop the progression of Alzheimer's disease, but it can help slow down the symptoms.
Razadyneis the brand name
Galantamine Hydrobromide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Razadyne
Galantamine
2001
94
Effectiveness
How Galantamine Hydrobromide Affects PatientsGalantamine works by increasing the levels of the chemical acetylcholine in both the brain and muscles. It does this by blocking an enzyme that breaks down acetylcholine, and by boosting how well acetylcholine binds to receptors. While taking galantamine won't stop the progression of dementia, it has been shown to improve cognition, daily functioning, and behavioral symptoms in people with Alzheimer's disease. Galantamine also has been studied in people with vascular dementia and those with Alzheimer's disease combined with cerebrovascular disease, and it is able to reverse symptoms of acute anticholinergic syndrome (e.g
How Galantamine Hydrobromide works in the bodyAlzheimer's disease is an irreversible brain disorder that leads to memory loss, cognitive decline, and the accumulation of abnormal proteins. It is caused by a gradual decrease in the number of cholinergic neurons, which are responsible for producing a neurotransmitter called acetylcholine. Galantamine is a drug that helps to treat Alzheimer's by blocking the breakdown of acetylcholine, resulting in higher levels of this neurotransmitter in the brain. It also binds to nicotinic acetylcholine receptors, which help to regulate the release of various neurotransmitters in the brain. This increased activity helps to improve cognitive performance and reduce behavioural symptoms
When to interrupt dosage
The measure of Galantamine Hydrobromide is contingent upon the determined affliction, including mild Dementia of the Alzheimer's Type, Alzheimer's Disease and Cerebrovascular Diseases. The amount of dosage fluctuates according to the technique of delivery as detailed in the table beneath.Condition
Dosage
Administration
mild Dementia of the Alzheimer's Type
, 8.0 mg, 16.0 mg, 24.0 mg, 4.0 mg, 12.0 mg, 4.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Alzheimer's Disease
, 8.0 mg, 16.0 mg, 24.0 mg, 4.0 mg, 12.0 mg, 4.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Alzheimer's Disease
, 8.0 mg, 16.0 mg, 24.0 mg, 4.0 mg, 12.0 mg, 4.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Alzheimer's Disease
, 8.0 mg, 16.0 mg, 24.0 mg, 4.0 mg, 12.0 mg, 4.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Cerebrovascular Diseases
, 8.0 mg, 16.0 mg, 24.0 mg, 4.0 mg, 12.0 mg, 4.0 mg/mL
, Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Solution, Solution - Oral
Warnings
Galantamine Hydrobromide has one contraindication, meaning it should be avoided if you have any of the conditions listed in the below table.Galantamine Hydrobromide ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Galantamine may interact with Pulse Frequency
Common Galantamine Hydrobromide Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Galantamine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Galantamine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Galantamine.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Galantamine.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Galantamine.
Galantamine Hydrobromide Toxicity & Overdose RiskThe toxic dose of galantamine in rats is 75mg/kg. Overdosing on galantamine can lead to a cholinergic crisis, which includes nausea, vomiting, abdominal cramping, tears, frequent urination and bowel movements, excessive sweating, slow heartbeat, low blood pressure, difficulty breathing, collapse and seizures. Muscle weakness or twitching may also occur. In some cases, hallucinations have been observed. If someone overdoses on galantamine, general supportive measures should be taken and atropine may be administered intravenously to reverse the effects of the drug. It is not known if galantamine can be removed from
Galantamine Hydrobromide Novel Uses: Which Conditions Have a Clinical Trial Featuring Galantamine Hydrobromide?
42 active investigations are looking into the potential of Galantamine Hydrobromide to alleviate Alzheimer's Disease, Dementia and related Cognitive Disorders.Condition
Clinical Trials
Trial Phases
mild Dementia of the Alzheimer's Type
0 Actively Recruiting
Alzheimer's Disease
0 Actively Recruiting
Cerebrovascular Diseases
1 Actively Recruiting
Not Applicable
Alzheimer's Disease
41 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable, Phase 1
Alzheimer's Disease
2 Actively Recruiting
Phase 3, Phase 2
Galantamine Hydrobromide Reviews: What are patients saying about Galantamine Hydrobromide?
5Patient Review
1/19/2010 This medication has been helpful for my dad with concentration and mood swings. We've found that the dosage does need to be adjusted every few months, but it is an overall effective treatment.
5Patient Review
11/22/2010 My mom has seen some improvement since taking this medication.
4.7Patient Review
9/4/2010 I wish more people would update us on how their loved ones are doing while taking this medication. My mother was just diagnosed with mild to moderate dementia and it's been really hard.
4.7Patient Review
9/6/2011 This medication really helped my grandma remember things again and improved her reading comprehension. However, after 8 months she may need a higher dosage. The pills sometimes give her bad nightmares though.
4.7Patient Review
4/2/2019 I started out with the low dose and increased to the slow release 24mg over the course of 3 years. I've had leg cramps and cold, numb feet as side effects, but my memory has improved. I was worried that Hydrobromide would cause a loss of libido, but it doesn't appear to be an issue.
4.3Patient Review
11/1/2016 My husband was diagnosed with a condition three weeks ago and we've already seen vast improvements in his focus, memory, and general well-being. The dosage will be increased in the coming weeks, but so far there have been no side effects that we're aware of. This has really helped him cope with the diagnosis and get back to living a normal life.
4.3Patient Review
9/4/20094Patient Review
1/28/2014 I felt great when I first started taking Galantamine, but now after 12 months I'm feeling less certain about my health.
3Patient Review
7/23/2013 After seven days of a 16mg dosage once a day I experienced lower back pain, trouble sleeping, depression, lower energy level, indigestion, blurry vision, difficulty swallowing, head aches, and taste problems.
2.7Patient Review
3/11/2013 This unfortunately did not help with my memory issues. If anything, I felt more confused and anxious after taking it.
2.7Patient Review
3/13/2011 My wife was on this medication for over a year. It helped for the first few months, but then her cognitive functions started to decline rapidly. The doctor took her off the drug and she hasn't found anything else that's helped since.
2Patient Review
3/11/2013 Unfortunately, this medication did not help me. In fact, the side effects were worse than the original problem.
1.3Patient Review
6/3/2018 I've only been on this medication for three weeks, and I'm not sure if I see much of a difference yet. Maybe I'm slightly less confused? However, I have been having a lot of leg cramps which may or may not be side effects.
Patient Q&A Section about galantamine hydrobromide
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is galantamine good for dementia?
"Galantamine can help improve memory, awareness, and daily functioning in people with mild to moderate Alzheimer's disease. It's unclear how it works exactly, but it's thought to increase the level of a chemical called acetylcholine in the brain. This chemical is important for memory and thinking."
Answered by AI
What is the drug galantamine used for?
"Galantamine can be used to help relieve mild to moderate dementia symptoms that are associated with Alzheimer's disease. It will not stop the progression of the disease, but may help improve memory and mental clarity."
Answered by AI
What does galantamine do to the brain?
"Galantamine is a medication that improves memory and thought by increasing the amount of a natural substance in the brain. Galantamine may help people with Alzheimer's disease by slowing the loss of these abilities."
Answered by AI
Who should not take galantamine?
"You shouldn't take this drug if you have severe liver disease. If you have moderate to severe kidney disease, you should not take more than 16 mg of this drug per day. Your doctor will adjust your dose accordingly."
Answered by AI