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What is Exforge Hct
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryAmlodipine is a medication used to treat high blood pressure and chest pain (angina). It belongs to a group of drugs called dihydropyridine calcium channel blockers which are associated with fewer side effects than other blood pressure medications. Amlodipine has antioxidant properties, helps produce nitric oxide which relaxes blood vessels, and can be taken once daily. It was approved by the FDA in 1987 and is a widely used antihypertensive drug.
Esidrixis the brand name
Exforge Hct Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 30 uses including Congestive Heart Failure and Hypertensive disease .Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Hypertension
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Congestive Heart Failure (CHF)
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Hypertension, Essential Hypertension
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
Hypertension
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Hypokalemia
Used to treat hypokalemia with solo treatment in combination with Triamterene
Cirrhosis of the Liver
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Hypertrophy, Left Ventricular
Used to treat Left Ventricular Hypertrophy in combination with Losartan
prophylaxis of preeclampsia
Helps manage prophylaxis of preeclampsia
Hypertension
Used to treat Antihypertensive Treatment in combination with Eprosartan
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Edema
Used to treat Edema in combination with Triamterene
Premenstrual tension with edema
Helps manage Premenstrual tension with edema
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Ascites
Used to treat Ascites in combination with Spironolactone
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
Effectiveness
How Exforge Hct Affects PatientsAmlodipine affects cell membranes, blocking calcium from getting into the cells. This helps lower blood pressure when taken regularly. It does not change heart rate or the levels of certain chemicals in the blood. Acute use of amlodipine can increase heart rate in those with angina and normal blood pressure, but long-term use does not have this effect. Amlodipine also improves chest pain associated with angina by increasing exercise time and decreasing the number of angina attacks.
How Exforge Hct works in the bodyAmlodipine works to lower blood pressure and relieve the symptoms of angina. It does this by blocking the movement of calcium ions into the cells of the heart and the blood vessels, which reduces the contraction of the heart and restricts the vessels. This decreases the amount of work the heart needs to do and lowers the total resistance against which it works. Amlodipine also widens the main coronary arteries and arterioles, increasing the oxygen delivery to the heart and reducing the vasoconstriction caused by smoking.
When to interrupt dosage
The measure of Exforge Hct is dependent upon the diagnosed condition, including inadequate reaction to diet, High Cardiovascular Risk and Lifestyle Modification. The quantity of dosage is contingent upon the method of delivery (e.g. Tablet, film coated or Tablet) featured in the table beneath.Condition
Dosage
Administration
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypokalemia
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Stroke
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertension
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Swollen feet or ankles
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Exforge Hct has one absolute contraindication, so it should not be administered when encountering any of the conditions specified in the below table.Exforge Hct ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Exforge Hct Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Exforge Hct Toxicity & Overdose RiskThe highest amount of amlodipine that is toxic to mice is 37mg/kg. An overdose of amlodipine can cause excessive dilation of the blood vessels, and serious and potentially deadly drops in blood pressure. There is no evidence that amlodipine causes cancer, gene or chromosome mutations, or affects fertility. Amlodipine has not been proven to be safe for pregnant or nursing women and should only be used if the benefits outweigh the risks. Nursing mothers should stop nursing while taking amlodipine.
Exforge Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Exforge Hct?
Currently, there are 46 active investigations assessing the potential of Exforge Hct to reduce High Cardiovascular Risk, Vasospastic Angina and Coronary Artery Disease (CAD).Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
12 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Sodium retention
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Cirrhosis
56 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 3, Phase 4, Early Phase 1
Diuretics
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Not Applicable, Phase 3, Phase 4, Early Phase 1, Phase 2, Phase 1
Swollen feet or ankles
7 Actively Recruiting
Phase 2, Not Applicable
restriction of fluid and sodium
0 Actively Recruiting
Hypertrophy, Left Ventricular
0 Actively Recruiting
Nephrotic Syndrome
4 Actively Recruiting
Phase 2, Not Applicable, Phase 3
Ascites
3 Actively Recruiting
Not Applicable, Phase 2
prophylaxis of calcium nephrolithiasis
0 Actively Recruiting
calcium channel blockers
0 Actively Recruiting
Hypokalemia
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Hypertension
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Edema
0 Actively Recruiting
Hypertension
294 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Phase 3, Early Phase 1, Phase 4
Diabetes Insipidus
1 Actively Recruiting
Phase 2
Exforge Hct Reviews: What are patients saying about Exforge Hct?
5Patient Review
6/7/2013 This medication is very effective in lowering my blood pressure. However, the side effects are quite unpleasant. I'm constantly tired and my resting pulse is now 90+. Additionally, I can't exercise because it makes me feel short of breath and my heart rate speeds up uncomfortably.
5Patient Review
4/21/2013 I unfortunately had a really bad reaction to this drug. After only taking it for one week, I woke up with severely swollen feet and ankles. My eyelids were also puffy and I was intensely itching all over my arms and legs.
5Patient Review
9/24/2019 My previous medications weren't working, so my doctor prescribed these. They worked very quickly; within two hours of taking the first pill, my blood pressure had fallen from 170 to 119. So far, so good.
5Patient Review
10/30/20125Patient Review
11/22/2012Patient Q&A Section about exforge hct
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.When is the best time to take Exforge HCT?
"The recommended dosage for Exforge HCT is one tablet per day, taken at the same time each day. Morning is the best time take the tablet. To consume, swallow the tablet whole with a glass of water."
Answered by AI
What is the difference between Exforge HCT and Exforge?
"Exforge contains two drugs in one pill, amlodipine and valsartan. Exforge HCT also contains hydrochlorothiazide."
Answered by AI
What is the side effect of Exforge?
"The most common side effects of Exforge HCT are dizziness, lightheadedness and headaches, which usually go away after a few days as your body gets used to the medication."
Answered by AI
What is Exforge HCT used for?
"What are the effects of Exforge HCT?
Exforge HCT can help to lower blood pressure in adults who have essential hypertension. The combination of drugs in Exforge HCT can also help to control blood pressure that is already adequately controlled."
Answered by AI
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