Edrophonium Chloride

curare overdosage, gallamine triethiodide, curare + 8 more

Treatment

12 FDA approvals

18 Active Studies for Edrophonium Chloride

Treatment for

curare overdosage

What is Edrophonium Chloride

Edrophonium

The Generic name of this drug

Treatment Summary

Edrophonium is a drug used to treat irregular heartbeats and diagnose myasthenia gravis. It works by increasing the amount of a chemical in the body called acetylcholine and can also be used as an antidote to certain muscle relaxants.

Enlon Plus

is the brand name

image of different drug pills on a surface

Edrophonium Chloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Enlon Plus

Edrophonium

1991

Approved as Treatment by the FDA

Edrophonium, otherwise known as Enlon Plus, is approved by the FDA for 12 uses such as Myasthenia Gravis and Respiratory Insufficiency .

Myasthenia Gravis

Respiratory Insufficiency

Used to treat Respiratory Depression in combination with Atropine

curare overdose

Used to treat curare overdose in combination with Atropine

tubocurarine

Myasthenia Gravis

Neuromuscular Blocking Agents

Used to treat nondepolarizing blocking agents in combination with Atropine

Neuromuscular Blockade

acetone

non-depolarizing neuromuscular blocking agents

gallamine triethiodide

curare overdosage

curare

Effectiveness

How Edrophonium Chloride Affects Patients

Edrophonium is a medication that works quickly and lasts for about 10 minutes. It helps people with myasthenia gravis by stopping the breakdown of a chemical (acetylcholine) that stimulates muscles. When this chemical is present in higher amounts, it helps the muscles respond better to nerve signals. This medication is given as an injection and starts to work within 30-60 seconds.

How Edrophonium Chloride works in the body

Edrophonium keeps acetylcholine active in the body for longer. Acetylcholine is a natural chemical that stimulates two types of receptors. Edrophonium stops an enzyme called acetylcholinesterase from breaking down acetylcholine, which keeps it active in the body for a longer period of time. This stimulation can have a variety of effects.

When to interrupt dosage

The measure of Edrophonium Chloride is subject to the determined affliction, including Neuromuscular Blocking Agents, non-depolarizing neuromuscular blocking agents and Neuromuscular Blockade. The amount of dosage is contingent upon the delivery method (e.g. Injection, solution or Intramuscular; Intravenous) featured in the table beneath.

Condition

Dosage

Administration

non-depolarizing neuromuscular blocking agents

10.0 mg/mL,

, Intramuscular; Intravenous, Injection, solution, Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous

gallamine triethiodide

10.0 mg/mL,

Neuromuscular Blocking Agents

10.0 mg/mL,

curare

10.0 mg/mL,

tubocurarine

10.0 mg/mL,

curare overdose

10.0 mg/mL,

Neuromuscular Blockade

10.0 mg/mL,

Myasthenia Gravis

10.0 mg/mL,

Respiratory Insufficiency

10.0 mg/mL,

acetone

10.0 mg/mL,

curare overdosage

10.0 mg/mL,

Warnings

There are 20 known major drug interactions with Edrophonium Chloride.

Common Edrophonium Chloride Drug Interactions

Drug Name

Risk Level

Description

Abacavir

Minor

Edrophonium may decrease the excretion rate of Abacavir which could result in a higher serum level.

Acetylcholine

Minor

The risk or severity of adverse effects can be increased when Edrophonium is combined with Acetylcholine.

Acrivastine

Minor

Edrophonium may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Agmatine

Minor

The therapeutic efficacy of Agmatine can be decreased when used in combination with Edrophonium.

Albutrepenonacog alfa

Minor

Edrophonium may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Edrophonium Chloride Toxicity & Overdose Risk

Overdosing on drugs in this class may lead to symptoms similar to those of muscarine poisoning, such as nausea, vomiting, diarrhea, sweating, increased secretions from the nose and mouth, and slow heart rate.

image of a doctor in a lab doing drug, clinical research

Edrophonium Chloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Edrophonium Chloride?

36 active studies are presently being conducted to investigate the potential of Edrophonium Chloride to counteract the effects of curare, Respiratory Depression and gallamine triethiodide.

Condition

Clinical Trials

Trial Phases

curare overdosage

0 Actively Recruiting

curare

0 Actively Recruiting

Neuromuscular Blockade

3 Actively Recruiting

Not Applicable, Phase 4

gallamine triethiodide

0 Actively Recruiting

Myasthenia Gravis

15 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1

tubocurarine

0 Actively Recruiting

non-depolarizing neuromuscular blocking agents

0 Actively Recruiting

Respiratory Insufficiency

0 Actively Recruiting

Neuromuscular Blocking Agents

0 Actively Recruiting

curare overdose

0 Actively Recruiting

acetone

0 Actively Recruiting

Patient Q&A Section about edrophonium chloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does edrophonium help myasthenia gravis?

"Edrophonium is a drug that prevents the breakdown of ACh (acetycholine). It rapidly improves symptoms of myasthenia gravis by increasing the concentration of ACh in the neuromuscular junction."

Answered by AI

What is edrophonium used for?

"Edrophonium injection is used to help diagnose myasthenia gravis, a disease characterized by severe muscle weakness. The injection can also be used to help select the proper treatment for the disease, or to reverse the effects of certain muscle relaxants such as gallamine or tubocurarine."

Answered by AI

What is Edrophonium chloride used to treat?

"Edrophonium is a medicine used to help diagnose a muscle disorder called myasthenia gravis, or to reverse the effects of certain medications used to prevent muscle contractions during surgical procedures."

Answered by AI

What type of medication is edrophonium?

"Edrophonium is a drug that inhibits the activity of the enzyme cholinesterase. It is used to diagnose and evaluate myasthenia gravis, a disease that causes muscle weakness. Edrophonium is also used to treat irregular heartbeats and as an antidote to certain poisons."

Answered by AI