Edrophonium Chloride

curare overdosage, gallamine triethiodide, curare + 8 more
Treatment
11 FDA approvals
20 Active Studies for Edrophonium Chloride

What is Edrophonium Chloride

EdrophoniumThe Generic name of this drug
Treatment SummaryEdrophonium is a drug used to treat irregular heartbeats and diagnose myasthenia gravis. It works by increasing the amount of a chemical in the body called acetylcholine and can also be used as an antidote to certain muscle relaxants.
Enlon Plusis the brand name
image of different drug pills on a surface
Edrophonium Chloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Enlon Plus
Edrophonium
1991
6

Approved as Treatment by the FDA

Edrophonium, otherwise known as Enlon Plus, is approved by the FDA for 11 uses such as Myasthenia Gravis and curare .
Myasthenia Gravis
curare
tubocurarine
Neuromuscular Blockade
acetone
Respiratory Depression
Used to treat Respiratory Depression in combination with Atropine
curare overdose
Used to treat curare overdose in combination with Atropine
non-depolarizing neuromuscular blocking agents
gallamine triethiodide
curare overdosage
Neuromuscular Blocking Agents
Used to treat nondepolarizing blocking agents in combination with Atropine

Effectiveness

How Edrophonium Chloride Affects PatientsEdrophonium is a medication that works quickly and lasts for about 10 minutes. It helps people with myasthenia gravis by stopping the breakdown of a chemical (acetylcholine) that stimulates muscles. When this chemical is present in higher amounts, it helps the muscles respond better to nerve signals. This medication is given as an injection and starts to work within 30-60 seconds.
How Edrophonium Chloride works in the bodyEdrophonium keeps acetylcholine active in the body for longer. Acetylcholine is a natural chemical that stimulates two types of receptors. Edrophonium stops an enzyme called acetylcholinesterase from breaking down acetylcholine, which keeps it active in the body for a longer period of time. This stimulation can have a variety of effects.

When to interrupt dosage

The measure of Edrophonium Chloride is subject to the determined affliction, including Neuromuscular Blocking Agents, non-depolarizing neuromuscular blocking agents and Neuromuscular Blockade. The amount of dosage is contingent upon the delivery method (e.g. Injection, solution or Intramuscular; Intravenous) featured in the table beneath.
Condition
Dosage
Administration
curare
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Neuromuscular Blockade
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
non-depolarizing neuromuscular blocking agents
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Neuromuscular Blocking Agents
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
tubocurarine
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
curare overdose
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Respiratory Depression
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
acetone
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
Myasthenia Gravis
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
curare overdosage
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous
gallamine triethiodide
10.0 mg/mL,
, Intramuscular; Intravenous, Injection, solution, Injection, solution - Intramuscular; Intravenous, Intravenous, Injection, solution - Intravenous, Liquid - Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Injection - Intravenous

Warnings

There are 20 known major drug interactions with Edrophonium Chloride.
Common Edrophonium Chloride Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Edrophonium may decrease the excretion rate of Abacavir which could result in a higher serum level.
Acetylcholine
Minor
The risk or severity of adverse effects can be increased when Edrophonium is combined with Acetylcholine.
Acrivastine
Minor
Edrophonium may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Agmatine
Minor
The therapeutic efficacy of Agmatine can be decreased when used in combination with Edrophonium.
Albutrepenonacog alfa
Minor
Edrophonium may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Edrophonium Chloride Toxicity & Overdose RiskOverdosing on drugs in this class may lead to symptoms similar to those of muscarine poisoning, such as nausea, vomiting, diarrhea, sweating, increased secretions from the nose and mouth, and slow heart rate.
image of a doctor in a lab doing drug, clinical research

Edrophonium Chloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Edrophonium Chloride?

36 active studies are presently being conducted to investigate the potential of Edrophonium Chloride to counteract the effects of curare, Respiratory Depression and gallamine triethiodide.
Condition
Clinical Trials
Trial Phases
non-depolarizing neuromuscular blocking agents
0 Actively Recruiting
tubocurarine
0 Actively Recruiting
Respiratory Depression
0 Actively Recruiting
curare overdosage
0 Actively Recruiting
gallamine triethiodide
0 Actively Recruiting
Neuromuscular Blocking Agents
0 Actively Recruiting
Neuromuscular Blockade
5 Actively Recruiting
Not Applicable, Phase 4, Early Phase 1
Myasthenia Gravis
27 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
acetone
0 Actively Recruiting
curare
0 Actively Recruiting
curare overdose
0 Actively Recruiting

Patient Q&A Section about edrophonium chloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How does edrophonium help myasthenia gravis?

"Edrophonium is a drug that prevents the breakdown of ACh (acetycholine). It rapidly improves symptoms of myasthenia gravis by increasing the concentration of ACh in the neuromuscular junction."

Answered by AI

What is edrophonium used for?

"Edrophonium injection is used to help diagnose myasthenia gravis, a disease characterized by severe muscle weakness. The injection can also be used to help select the proper treatment for the disease, or to reverse the effects of certain muscle relaxants such as gallamine or tubocurarine."

Answered by AI

What is Edrophonium chloride used to treat?

"Edrophonium is a medicine used to help diagnose a muscle disorder called myasthenia gravis, or to reverse the effects of certain medications used to prevent muscle contractions during surgical procedures."

Answered by AI

What type of medication is edrophonium?

"Edrophonium is a drug that inhibits the activity of the enzyme cholinesterase. It is used to diagnose and evaluate myasthenia gravis, a disease that causes muscle weakness. Edrophonium is also used to treat irregular heartbeats and as an antidote to certain poisons."

Answered by AI

Clinical Trials for Edrophonium Chloride

Have you considered Edrophonium Chloride clinical trials? We made a collection of clinical trials featuring Edrophonium Chloride, we think they might fit your search criteria.
Have you considered Edrophonium Chloride clinical trials? We made a collection of clinical trials featuring Edrophonium Chloride, we think they might fit your search criteria.
Have you considered Edrophonium Chloride clinical trials? We made a collection of clinical trials featuring Edrophonium Chloride, we think they might fit your search criteria.
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