Celecoxib

Rheumatoid Arthritis, Arthritis, Juvenile, Osteoarthritis + 5 more
Treatment
10 FDA approvals
20 Active Studies for Celecoxib

What is Celecoxib

CelecoxibThe Generic name of this drug
Treatment SummaryCelecoxib is a medication used to reduce inflammation and treat pain caused by arthritis. It is also used to reduce the risk of precancerous polyps in people with a genetic condition called familial adenomatous polyposis. Celecoxib is an NSAID, meaning it is a nonsteroidal anti-inflammatory drug, and is known to have a lower risk of causing gastrointestinal bleeding than other NSAIDs. It was approved by the FDA in 1998 and is sold under the brand name Celebrex. Celecoxib has also been studied as a potential cancer-fighting drug in clinical trials.
Celebrexis the brand name
image of different drug pills on a surface
Celecoxib Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Celebrex
Celecoxib
1998
379

Approved as Treatment by the FDA

Celecoxib, otherwise called Celebrex, is approved by the FDA for 10 uses which include Arthritis, Juvenile and Acute Pain .
Arthritis, Juvenile
Helps manage Rheumatoid Arthritis, Juvenile
Acute Pain
Helps manage Pain, Acute
Ankylosing Spondylitis (AS)
Helps manage Ankylosing Spondylitis (AS)
Pain, Acute
Helps manage Pain, Acute
Osteoarthritis (OA)
Helps manage Osteoarthritis (OA)
Rheumatoid Arthritis, Juvenile
Helps manage Rheumatoid Arthritis, Juvenile
Ankylosing Spondylitis
Helps manage Ankylosing Spondylitis (AS)
Rheumatoid Arthritis
Helps manage Rheumatoid Arthritis
Primary Dysmenorrhoea
Helps manage Primary Dysmenorrhoea
Osteoarthritis
Helps manage Osteoarthritis (OA)

Effectiveness

How Celecoxib Affects PatientsCelecoxib is a painkiller and anti-inflammatory that reduces pain and swelling by stopping the COX-2 enzyme from working. Although it is less likely to cause bleeding than other NSAIDs, it is still possible and should be used with caution in those at high risk for gastrointestinal bleeding. In the early 2000s, concerns were raised about the safety of COX-2 inhibitors including Vioxx. After studying data from large clinical trials, the FDA concluded that there was a risk of cardiovascular events with both COX-2 inhibitors and nonselective NSAIDs, but that the benefits of celecoxib outweighed
How Celecoxib works in the bodyCelecoxib is a type of drug called a non-steroidal anti-inflammatory (NSAID). It works by blocking an enzyme called cyclooxygenase-2 (COX-2), which reduces the amount of certain substances that cause pain and inflammation. Unlike other NSAIDs, celecoxib has less of an effect on the stomach and causes less ulceration. Celecoxib also has anticancer effects by binding to certain proteins and inhibiting certain signaling pathways. The use of celecoxib may also increase the risk of thrombotic events because it stops the production of substances that inhibit platelet aggregation.

When to interrupt dosage

The advisable dosage of Celecoxib is subject to the diagnosed affliction, including Ankylosing Spondylitis, Primary Dysmenorrhoea and Rheumatoid Arthritis. The quantity of dosage is contingent upon the way of administration (e.g. Tablet - Oral or Oral) listed in the table beneath.
Condition
Dosage
Administration
Rheumatoid Arthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Arthritis, Juvenile
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Osteoarthritis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Ankylosing Spondylitis
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Acute Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Primary Dysmenorrhoea
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Therapeutic procedure
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid
Pain
50.0 mg, , 100.0 mg, 200.0 mg, 400.0 mg, 25.0 mg/mL, 56.0 mg, 120.0 mg/mL
, Oral, Capsule, Capsule - Oral, Oral; Topical, Kit - Oral; Topical, Kit, Kit - Oral, Tablet - Oral, Tablet, Solution, Solution - Oral, Liquid - Oral, Liquid

Warnings

Celecoxib Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Celecoxib may interact with Pulse Frequency
There are 20 known major drug interactions with Celecoxib.
Common Celecoxib Drug Interactions
Drug Name
Risk Level
Description
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Celecoxib.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Celecoxib.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Celecoxib is combined with Cyclopentamine.
Fluorouracil
Major
The metabolism of Fluorouracil can be decreased when combined with Celecoxib.
Fosphenytoin
Major
The metabolism of Fosphenytoin can be decreased when combined with Celecoxib.
Celecoxib Toxicity & Overdose RiskCelecoxib should not be given to those with kidney or liver problems as it could be toxic and cause adverse side effects. Overdosing on celecoxib may cause breathing difficulties, drowsiness, stomach bleeding, high blood pressure, kidney failure, nausea, sluggishness, stomach pain, and vomiting. If the patient has taken celecoxib within the last 4 hours, vomiting or activated charcoal should be induced. Diuresis, alkalinization of urine, hemodialysis or hemoperfusion may not help if the drug is highly protein bound. Patients should be monitored for signs and symptoms of gastrointestinal bleeding.
image of a doctor in a lab doing drug, clinical research

Celecoxib Novel Uses: Which Conditions Have a Clinical Trial Featuring Celecoxib?

102 active clinical trials are presently examining the utility of Celecoxib in providing relief from Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis and Primary Dysmenorrhoea.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
53 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Acute Pain
1 Actively Recruiting
Not Applicable
Ankylosing Spondylitis
3 Actively Recruiting
Phase 3, Not Applicable
Pain
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Arthritis, Juvenile
1 Actively Recruiting
Not Applicable
Primary Dysmenorrhoea
1 Actively Recruiting
Not Applicable
Therapeutic procedure
0 Actively Recruiting

Celecoxib Reviews: What are patients saying about Celecoxib?

5Patient Review
4/17/2021
Celecoxib for Joint Damage causing Pain and Loss of Function
I've been dealing with arthritis for a few years now and haven't had much relief from Mobic. I just had a partial knee replacement, and my doctor put me on Celebrex. It's been fantastic! Not only does it relieve the pain in my other joints (hips, knees, back), but it also allows me to be more active since I'm not constantly in pain. I just wish I could take this long-term.
5Patient Review
6/22/2021
Celecoxib for Acute Pain Following an Operation
Three weeks ago, I had a knee replacement. The hospital put me on this medication for pain relief and, finally, I have no pain. There is still discomfort from the healing process but that's to be expected. Now I can try to get my life back and start exercising again.
5Patient Review
10/9/2022
Celecoxib for Joint Damage causing Pain and Loss of Function
I've taken this medication for years with great results. Recently, however, the pain has come back almost as severe as it was when I first started taking the medication. Has anyone else experienced this?
5Patient Review
3/2/2022
Celecoxib for Rheumatoid Arthritis
This medication has really helped me. I have bursitis in my hips and was struggling with stiffness and quality of life. Taking just one 100mg pill a day has alleviated all of those issues.
5Patient Review
11/23/2017
Celecoxib for Acute Pain Following an Operation
5Patient Review
12/5/2017
Celecoxib for Joint Damage causing Pain and Loss of Function
5Patient Review
11/7/2019
Celecoxib for Pain
This medication is very effective at managing my pain after several knee surgeries.
5Patient Review
8/17/2020
Celecoxib for Pain
I have severe pain and inflammation from fibromyalgia, DDD and osteoarthritis of the spine. I've tried everything over-the-counter, but this is the only thing that has really given me relief.
4.3Patient Review
1/11/2019
Celecoxib for Joint Damage causing Pain and Loss of Function
I experienced nausea and severe heartburn when using this medication, even though I was also taking Pantoprazole. It did have a modest effect on my pain, but now I have other problems as a result.
3Patient Review
5/16/2020
Celecoxib for Joint Damage causing Pain and Loss of Function
I was in a lot of pain after my accident, but Celebrex really helped. I would recommend taking it with food to avoid stomach upset, and using ice or heat packs as well.
3Patient Review
5/24/2021
Celecoxib for Joint Damage causing Pain and Loss of Function
I used celecoxib for pain and inflammation from a back surgery 5 months ago. It did help, but after about ten days I started to experience some serious stomach pain. I'm sensitive to NSAIDs, and while that wasn't an issue at first, it quickly became one.
2.7Patient Review
6/27/2021
Celecoxib for Joint Damage causing Pain and Loss of Function
While this treatment did not fully take away my pain, it was a marked improvement from other options I've tried.
2.3Patient Review
12/29/2020
Celecoxib for Joint Damage causing Pain and Loss of Function
I still have a lot of pills left over from this treatment! It didn't work any better for me than the NSAIDs I've tried in the past. The only thing that's helped me is Prednisone, but I know that's not a long-term solution. Is there anything else out there that can replicate the good effects without the bad side effects?
2.3Patient Review
2/22/2018
Celecoxib for Pain
This has relieved the pain and swelling in my knees to a point where I can walk without discomfort. The generic version works just as well, so there's no need to overspend.
1Patient Review
2/18/2018
Celecoxib for Joint Damage causing Pain and Loss of Function
Not only did this completely remove the pain I was experiencing, but it also took care of the inflammation in the operated-on area. This made it so that walking didn't make the swelling worse like it did before. Much better than panadol oeteo and endone!
1Patient Review
2/18/2022
Celecoxib for Rheumatoid Arthritis
I had an extreme allergic reaction to this medication, going into anaphylaxis after only taking one pill. My lips, tongue, and throat swelled up within a few hours, and I had to go to the emergency room.
1Patient Review
7/29/2018
Celecoxib for Joint Damage causing Pain and Loss of Function
I'm 200mg into this treatment and I haven't felt any relief from my pain or swelling.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about celecoxib

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the major side effect of celecoxib?

"If you experience any of the following symptoms, you may be suffering from indigestion: stomach pain, heartburn, gas, diarrhea, constipation, nausea, vomiting; swelling in your hands or feet; dizziness; or cold symptoms such as stuffy nose, sneezing, sore throat."

Answered by AI

What kind of pain killer is celecoxib?

"Celecoxib reduces inflammation by blocking the production of natural substances that cause it. This can decrease swelling, pain, or fever."

Answered by AI

What is celecoxib be used for?

"Celecoxib is an anti-inflammatory drug used to treat mild to moderate pain and help relieve symptoms of arthritis."

Answered by AI

Is celecoxib stronger than ibuprofen?

"There is no definitive answer as to which medication is better for pain relief as it depends on the specific type of pain."

Answered by AI

Clinical Trials for Celecoxib

Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Image of Humana Healthcare Research, Inc. in Louisville, United States.

Academic Detailing for Rheumatoid Arthritis

Any Age
All Sexes
Louisville, KY
The goal of this trial is to learn if an interactive evidence-based educational outreach visits to clinicians who prescribe biologics change prescribing of biosimilar medications. The main questions it aims to answer are: 1. Do educational outreach visits lead to a higher number of prescriptions for biosimilar versions of adalimumab? 2. Do in-person or virtual visits work better? Researchers will compare clinicians offered the educational outreach visit to those who are not offered the visit to see if there is a difference in prescribing of biosimilar versions of adalimumab instead of the original brand-name version. Participants will be offered the chance to meet with a trained clinician who will provide educational information tailored to their knowledge and attitudes on the topic. They will also be provided an educational brochure and patient educational materials.
Waitlist Available
Has No Placebo
Humana Healthcare Research, Inc. (+1 Sites)
Image of Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016) in New York, United States.

Electromagnetic Resonance Therapy for Autoimmune Diseases

Any Age
All Sexes
New York, NY
The ImmuneNet study is a Phase I/II clinical trial sponsored by Truway Health, Inc. It will test whether gentle, low-frequency electromagnetic resonance (LF-EMR) can influence how immune cells communicate and synchronize with each other. The goal is to see if this "quantum-synaptic" signaling effect can help stabilize immune activity and reduce the number of autoimmune flare-ups in people living with conditions such as lupus, rheumatoid arthritis, or multiple sclerosis. Participants will receive either an active or a sham (placebo) LF-EMR session three times per week for twelve weeks. Each session is completely non-invasive. Blood samples will be collected to study cytokines (immune-system messenger molecules), gene-expression patterns, and electrical field coherence among immune cells. A machine-learning system will analyze these data to predict inflammation patterns and guide individualized treatment settings. All participant data will be securely recorded and time-stamped to ensure transparency and privacy. The expected outcome of the study is a measurable reduction in autoimmune flare frequency and symptom severity, along with improved understanding of how electromagnetic signaling might safely regulate immune function.
Phase 1 & 2
Waitlist Available
Truway Health, Inc. www.truwayhealth.com (401 E 34th Street, S11P, New York, NY 10016)Gavin Solomon, President & CEOTruway Health, Inc.
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Image of St. Lawrence Health in Potsdam, United States.

Primary Care for Rheumatoid Arthritis

18+
All Sexes
Potsdam, NY
Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the joints. This disease effects lots of people in the US and can lead to major joint damage if not properly treated. In rural areas like northern NY, these are underserved areas for RA patients, thus many patients struggle to get the appropriate care. This model is testing whether primary care providers (PCP) can safely and effectively provide stable RA patients with the proper treatment rather than send them to a specialist. PCPs were trained through classes, case reviews, and a final exam. Patients will be randomly assigned to either see a trained PCP or their normal rheumatologist at the rheumatology clinic. This study will examine how patients are doing over a year using medical exams and patient feedback. If this model proves to be successful, it will make RA treatment easier and more affordable for patients.
Recruiting
Has No Placebo
St. Lawrence HealthEyal Kedar, MD
Image of Pender Community Health Centre in Vancouver, Canada.

Personalized Outreach for Rheumatic Diseases

18+
All Sexes
Vancouver, Canada
The primary goal of this study is to determine whether providing patient honoraria and/or outreach services can improve the attendance rate of appointments at an inner city rheumatology clinic in Vancouver, British Columbia. The main question it aims to answer are: * Does providing a financial honorarium ($20 for each follow-up appointment with completed bloodwork) improve attendance rate at an inner city rheumatology clinic? * Does providing a personalized outreach service for rheumatic diseases improve attendance rate at an inner city rheumatology clinic? The researchers will compare providing patient honoraria to providing both honoraria and outreach services, and compare each of these to the regular appointment schedule without honoraria or outreach. Participants will: * Undergo randomization to receive honoraria or honoraria and outreach services together * Complete surveys about their health and understanding of their rheumatic disease at baseline, 3-month, and 6-month intervals * Visit the clinic every month for check-ups and monitoring bloodwork if they are started on immunosuppressants for their condition
Waitlist Available
Has No Placebo
Pender Community Health CentreBrent R Ohata, MD
Have you considered Celecoxib clinical trials? We made a collection of clinical trials featuring Celecoxib, we think they might fit your search criteria.Go to Trials
Image of Clinical Research Of West Florida - Phase I Unit /ID# 272428 in Clearwater, United States.

Targeted Therapies for Rheumatoid Arthritis

18+
All Sexes
Clearwater, FL
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Clinical Research Of West Florida - Phase I Unit /ID# 272428 (+30 Sites)ABBVIE INC.AbbVie
Have you considered Celecoxib clinical trials? We made a collection of clinical trials featuring Celecoxib, we think they might fit your search criteria.Go to Trials
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