Banzel

Lennox Gastaut Syndrome

Treatment

2 FDA approvals

3 Active Studies for Banzel

Treatment for

Lennox Gastaut Syndrome

What is Banzel

RufinamideThe Generic name of this drug

Treatment SummaryRufinamide is a drug used to treat seizure disorders like Lennox-Gastuat syndrome, a form of childhood epilepsy. It works by controlling the abnormal electrical activity in the brain that leads to seizures. Clinical studies have shown that it is effective in treating partial seizures.

Banzelis the brand name

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Banzel Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Banzel

Rufinamide

2008

Approved as Treatment by the FDA

Rufinamide, also known as Banzel, is approved by the FDA for 2 uses such as Lennox Gastaut Syndrome (LGS) and Lennox Gastaut Syndrome .

Lennox Gastaut Syndrome (LGS)

Used in combination with other therapies

Lennox Gastaut Syndrome

Used in combination with other therapies

Effectiveness

How Banzel Affects PatientsAt high doses, this drug prevents the production of glutamate by blocking the activity of a certain type of brain receptor (mGluR5).

How Banzel works in the bodyRufinamide is a medication used to treat epilepsy. It works by making it harder for electric signals to spread through the brain, which helps to stop seizures from happening. It does this by making voltage-gated sodium channels stay inactive for longer, which helps to stabilize the brain's membranes.

When to interrupt dosage

The prescribed measure of Banzel is contingent upon the recognized condition. The amount of dosage also depends on the technique of delivery outlined in the table beneath.

Condition

Dosage

Administration

Lennox Gastaut Syndrome

, 200.0 mg, 400.0 mg, 40.0 mg/mL, 100.0 mg

, Oral, Tablet, film coated, Tablet, film coated - Oral, Suspension, Suspension - Oral, Tablet, Tablet - Oral

Warnings

Banzel has one restriction. It should not be administered when enduring the conditions presented in the following table.Banzel Contraindications

Condition

Risk Level

Notes

familial short QT syndrome

Do Not Combine

There are 20 known major drug interactions with Banzel.

Common Banzel Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Rufinamide.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Rufinamide.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Rufinamide.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Rufinamide.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Rufinamide.

Banzel Toxicity & Overdose RiskCommon side effects of this drug include headache, dizziness, tiredness, drowsiness, and nausea.

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Banzel Novel Uses: Which Conditions Have a Clinical Trial Featuring Banzel?

Currently, 4 active trials are examining the utility of Banzel for treatment of Lennox Gastaut Syndrome (LGS).

Condition

Clinical Trials

Trial Phases

Lennox Gastaut Syndrome

3 Actively Recruiting

Phase 2, Phase 1, Phase 4

Banzel Reviews: What are patients saying about Banzel?

5Patient Review

9/29/2014

Banzel for Petit Mal Epilepsy with Multiple Seizure Types

I didn't think this medication was working well at first, but when the doctor tried reducing my dosage I realized just how much it was helping me.

5Patient Review

10/7/2014

Banzel for Petit Mal Epilepsy with Multiple Seizure Types

This is by far the best medication I have taken.

4.7Patient Review

2/1/2011

Banzel for Petit Mal Epilepsy with Multiple Seizure Types

This treatment has been really helpful for me. It's made a big difference in my life.

4.3Patient Review

2/17/2014

Banzel for Petit Mal Epilepsy with Multiple Seizure Types

This medication has been incredibly helpful, reducing my seizure frequency from 8 a day to just 4 or 6. The only downside is the price tag; it's quite expensive at $2400 per month.

3.7Patient Review

8/17/2010

Banzel for Epilepsy of the Lennox Gastaut Syndrome

My daughter was having tonic seizures every 5 minutes, despite also taking dilantil, felbatol, keppra, and klonopin. Banzel was added around March 2010, and by August 2010 we'd increased the dosage to 1600mg per day. The effect was amazing, but getting there was tough – she vomited a lot. Now as long as we feed her before she takes the meds, she's fine. She's 30 years old and has been disabled since birth due to uncontrolled seizures. This drug seems to be working for her.

View All Reviews

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Patient Q&A Section about banzel

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the generic for BANZEL?

"The generic version of Rufinamide (Banzel) is available and may be cheaper compared to the brand version."

Answered by AI

Can you overdose on BANZEL?

"If you take too much Banzel, you may have an overdose. Overdose symptoms may include confusion, drowsiness, and seizures. If you think you may have overdosed on Banzel, call your doctor or poison control center right away."

Answered by AI

What is BANZEL used for?

"Banzel is a prescription medication approved for treating seizures associated with Lennox-Gastaut Syndrome in patients aged one year and older."

Answered by AI

What is BANZEL made of?

"Banzel contains rufinamide, an active drug that belongs to a class of medications called antiepileptic drugs (AEDs). A class of medications is a group of drugs that work in the same way. Banzel is available as 200-milligram (mg) and 400-mg tablets."

Answered by AI