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What is Atacand Hct
HydrochlorothiazideThe Generic name of this drug
Treatment SummaryHydrochlorothiazide is a common medication used to treat fluid retention and high blood pressure. It is usually prescribed together with other medications like angiotensin converting enzyme inhibitors or angiotensin II receptor blockers. The drug has been around since 1959 and is still used today, although it is being gradually replaced by other medications.
Esidrixis the brand name
Atacand Hct Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Esidrix
Hydrochlorothiazide
1959
2181
Approved as Treatment by the FDA
Hydrochlorothiazide, also called Esidrix, is approved by the FDA for 22 uses including Stroke and calcium channel blockers .Stroke
Used to treat Cerebrovascular Accident in combination with Losartan
calcium channel blockers
Used to treat calcium channel blockers in combination with Eprosartan
inadequate response to other therapeutic measures
Used to treat inadequate response to other therapeutic measures in combination with Spironolactone
inadequate control of blood pressure with monotherapy
Used to treat inadequate control of blood pressure with monotherapy in combination with Aliskiren
Antepartum magnesium sulfate prophylaxis
Helps manage prophylaxis of preeclampsia
Congestive Heart Failure
Used to treat Congestive Heart Failure (CHF) in combination with Spironolactone
Antihypertensive Treatment
Used to treat Antihypertensive Treatment in combination with Eprosartan
hypokalemia with solo treatment
Used to treat hypokalemia with solo treatment in combination with Triamterene
Bedrest
Used to treat Bedrest in combination with Spironolactone
Cirrhosis
Used to treat Cirrhosis of the Liver in combination with Spironolactone
Diuretics
Used to treat Hypokalemia caused by diuretics in combination with Amiloride
restriction of fluid and sodium
Used to treat restriction of fluid and sodium in combination with Spironolactone
Edema
Helps manage Premenstrual tension with edema
Hypertensive disease
Used to treat Hypertension, Essential Hypertension in combination with Spironolactone
blood pressure inadequately controlled with monotherapy
Used to treat blood pressure inadequately controlled with monotherapy in combination with Irbesartan
Sodium retention
Used to treat Sodium retention in combination with Spironolactone
Swollen feet or ankles
Used to treat Edema in combination with Triamterene
Ascites
Used to treat Ascites in combination with Spironolactone
Nephrotic Syndrome
Used to treat Nephrotic Syndrome in combination with Spironolactone
Therapeutic procedure
Used to treat inadequate response to treatment in combination with Spironolactone
Left Ventricular Hypertrophy
Used to treat Left Ventricular Hypertrophy in combination with Losartan
Hypertensive disease
Used to treat High Blood Pressure (Hypertension) in combination with Losartan
Effectiveness
How Atacand Hct Affects PatientsHydrochlorothiazide helps to eliminate excess water in the body by preventing it from being reabsorbed in the kidneys. The amount of this medication taken can vary, but typically ranges from 25-100mg. People who have reduced kidney or liver function should be cautious when taking this medication.
How Atacand Hct works in the bodyHydrochlorothiazide works by reducing the amount of sodium and water absorbed back into the body. It is first taken up by special proteins in the cells of the distal convoluted tubule and then moved to the lumen of the tubule. Normally, sodium is reabsorbed by these cells and pumped into the surrounding area, which causes water to be reabsorbed as well. Hydrochlorothiazide blocks this process by stopping a protein called SLC12A3 from taking up sodium and water, so less of it is absorbed back into the body.
When to interrupt dosage
The proposed measure of Atacand Hct is contingent upon the identified affliction, such as Antepartum magnesium sulfate prophylaxis, hypertension inadequately managed with monotherapy and antihypertensives. The dose fluctuates in accordance with the approach of delivery (e.g. Tablet, coated - Oral or Oral) featured in the following table.Condition
Dosage
Administration
inadequate control of blood pressure with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Nephrotic Syndrome
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
prophylaxis of calcium nephrolithiasis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antepartum magnesium sulfate prophylaxis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
calcium channel blockers
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diabetes Insipidus
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Congestive Heart Failure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
inadequate response to other therapeutic measures
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Bedrest
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Cirrhosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Hypertensive disease
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Renal tubular acidosis
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
restriction of fluid and sodium
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Therapeutic procedure
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Diuretics
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
blood pressure inadequately controlled with monotherapy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Antihypertensive Treatment
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Edema
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Left Ventricular Hypertrophy
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Ascites
12.5 mg, , 25.0 mg, 50.0 mg, 15.0 mg, 6.25 mg, 0.25 mg, 0.125 mg, 100.0 mg, 2.5 mg/mg, 5.0 mg/mg, 30.0 mg, 0.0125 mg
Oral, Tablet, film coated, Tablet, film coated - Oral, , Tablet, Tablet - Oral, Capsule - Oral, Capsule, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Atacand Hct has two contraindications, thus it should not be utilized if you have any of the issues outlined in the following table.Atacand Hct ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Anuria
Do Not Combine
Common Atacand Hct Drug Interactions
Drug Name
Risk Level
Description
Amifostine
Major
Hydrochlorothiazide may increase the hypotensive activities of Amifostine.
Cyclopentamine
Major
The risk or severity of adverse effects can be increased when Hydrochlorothiazide is combined with Cyclopentamine.
Dofetilide
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Dofetilide.
Fenofibrate
Major
The therapeutic efficacy of Fenofibrate can be decreased when used in combination with Hydrochlorothiazide.
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Hydroxyzine.
Atacand Hct Toxicity & Overdose RiskThe lowest toxic dose of hydrochlorothiazide in mice and rats is greater than 10g/kg. Symptoms of overdose can include low potassium, chloride, and sodium levels in the blood. Treatment for overdose should include fluids, electrolytes, and vasopressors to manage low blood pressure, as well as oxygen for breathing difficulties.
Atacand Hct Novel Uses: Which Conditions Have a Clinical Trial Featuring Atacand Hct?
158 active trials are currently underway to assess the potential of Atacand Hct in managing Cirrhosis, Edema and Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Antihypertensive Treatment
0 Actively Recruiting
Swollen feet or ankles
40 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 3, Phase 4
Renal tubular acidosis
0 Actively Recruiting
Antepartum magnesium sulfate prophylaxis
18 Actively Recruiting
Phase 1, Not Applicable, Phase 3, Early Phase 1, Phase 2, Phase 4
Congestive Heart Failure
23 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Hypertensive disease
19 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Cirrhosis
50 Actively Recruiting
Phase 1, Phase 2, Not Applicable, Phase 4, Phase 3, Early Phase 1
inadequate control of blood pressure with monotherapy
0 Actively Recruiting
Ascites
10 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2
Diabetes Insipidus
1 Actively Recruiting
Phase 1
Stroke
11 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
calcium channel blockers
0 Actively Recruiting
Nephrolithiasis
0 Actively Recruiting
hypokalemia with solo treatment
0 Actively Recruiting
blood pressure inadequately controlled with monotherapy
0 Actively Recruiting
inadequate response to other therapeutic measures
0 Actively Recruiting
Diuretics
0 Actively Recruiting
Bedrest
0 Actively Recruiting
Therapeutic procedure
0 Actively Recruiting
Sodium retention
0 Actively Recruiting
Atacand Hct Reviews: What are patients saying about Atacand Hct?
5Patient Review
3/3/2010 Though this drug has been very effective in managing my blood pressure, the cost is unfortunately too high for me to continue using it. I am retired and on a fixed income, so paying $270.94 for a 90 day supply is not feasible. Are there any other options out there that would be just as effective but cheaper?
5Patient Review
6/28/2013 I had to switch back to the name brand because the generic wasn't working, but my insurance company is giving me a lot of trouble. They're making it very difficult for my doctor and I to get the medication we need at the correct copay amount, even though my physician has determined that this is medically necessary.
5Patient Review
11/30/2012 My doctor had to switch my medication because my insurance wouldn't cover the last one. My blood pressure has been up and down since, so she told me to keep a chart and bring it to my next appointment.
5Patient Review
3/26/2010 I've been on this medication for a month and my blood pressure has stayed around 125/75 or lower. I occasionally get headaches, but they're relieved with aspirin; no difference in urine output, seems effective for me.
5Patient Review
1/27/2010 This medication has been great for keeping my blood pressure at a healthy level. When I first started taking it, I was getting dizzy spells, but my doctor made an adjustment and now I'm doing much better.
5Patient Review
3/4/20095Patient Review
7/31/20095Patient Review
4/19/2010 I've been using this medication for years and it's always been effective. I haven't even considered switching to a generic, even though it's more expensive.
5Patient Review
6/19/2010 Atacand HCL is the only high blood pressure medication that has worked for me out of five different tries.
4.7Patient Review
3/2/2010 I have had trouble with various blood pressure medications in the past, but this one has been the most effective for me. I cannot tolerate calcium channel blockers, beta blockers, or alpha blockers.
4.7Patient Review
3/2/2010 I found this treatment really effective in keeping my blood pressure at a normal level.
4.3Patient Review
4/14/2013 So far, I haven't coughed at all since taking this medication. I'm a bit worried about the potential interactions with potassium, but I'll give it a little more time.
4.3Patient Review
1/24/2013 I had some mild side effects like swelling, a rash, and dry skin, but overall this medication was really effective at helping me with my breathing problems.
4Patient Review
11/14/2010 I find that this medication can sometimes make me feel exhausted and cause excessive sweating.
4Patient Review
2/26/20094Patient Review
8/5/20093.7Patient Review
11/1/2010 Though it is expensive, this is the only medication that has worked for me. I'm currently ordering it from Canada for $135.00/90 days.
3.3Patient Review
9/19/2010 I've been on Atacand HCT for over five years to help control my blood pressure. I had to switch to Hyzaar due to an insurance company change, but it's not working as well for me. The joint pain is much more pronounced! I'll have to switch back to Atacand.
3.3Patient Review
3/30/2013 I had to stop taking this medication because it caused severe dizziness and anxiety attacks. Although, it did help lower my blood pressure somewhat.
1.3Patient Review
1/13/2013 I was really pleased that this had no side effects for me. The price is unfortunately quite high, but I'm hoping it will become more affordable when the patent expires in December 2012.
Patient Q&A Section about atacand hct
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What is candesartan HCT used for?
"The Candesartan and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure increases the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly."
Answered by AI
Does Atacand contain hydrochlorothiazide?
"Each tablet of Atacand Plus 32/25 contains 32 mg of candesartan cilexetil and 25 mg of hydrochlorothiazide as the active ingredients."
Answered by AI
Is Atacand a water pill?
"No, candesartan does not make you urinate more. It is not a diuretic or "water pill." However, there is a combination pill that contains candesartan plus a diuretic."
Answered by AI