Astepro

Blepharitis allergic, Rhinitis, Vasomotor, Hay Fever + 6 more

Treatment

2 Active Studies for Astepro

Treatment for

Blepharitis allergic

What is Astepro

Azelastine

The Generic name of this drug

Treatment Summary

Azelastine is a medication used to treat allergies and swelling in the nose. It comes in a nasal spray and an eye drop form, and was first approved by the FDA in 1996. Azelastine is also available as a combination nasal spray with fluticasone propionate, called Dymista, which can be used to treat seasonal allergies in patients 6 years of age and older.

Astelin

is the brand name

image of different drug pills on a surface

Astepro Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Astelin

Azelastine

1996

56

Effectiveness

How Astepro Affects Patients

Azelastine blocks histamine, reducing symptoms of allergies. It starts working within 15 minutes when taken as a nasal spray, or 3 minutes when used as eye drops. Its effects can last up to 12 hours.

How Astepro works in the body

Azelastine is a drug used to treat allergies. It works by blocking histamine receptors in the body that cause allergy symptoms such as itching, sneezing, and congestion. It also has the ability to stabilize mast cells so they can't release inflammatory molecules, and it reduces the production of leukotrienes and other substances that cause inflammation. Finally, it can reduce levels of substance P and bradykinin in nasal secretions, which cause nasal itching and sneezing.

When to interrupt dosage

The suggested portion of Astepro is contingent upon the diagnosed situation, including Hay Fever, Disorder of eye and Keratoconjunctivitis. The measure of dosage differs, as per the mode of delivery (e.g. Nasal or Solution / drops) featured in the table beneath.

Condition

Dosage

Administration

Keratoconjunctivitis

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Administration, Intranasal

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

allergic eye disorders

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Rhinitis, Vasomotor

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Blepharitis allergic

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Rhinitis, Allergic

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Allergy to Tree Pollen

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Hay Fever

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Allergic Conjunctivitis (AC)

, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation

, Nasal, Spray, metered, Spray, metered - Nasal, Spray, Spray - Nasal, Ophthalmic, Solution / drops - Ophthalmic, Intraocular, Solution / drops - Intraocular, Solution / drops

Warnings

There are 20 known major drug interactions with Astepro.

Common Astepro Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Azelastine.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Azelastine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Azelastine.

Copanlisib

Major

The metabolism of Copanlisib can be decreased when combined with Azelastine.

Astepro Toxicity & Overdose Risk

Taking too much azelastine through the nose or eyes is unlikely to cause serious side effects, but can make you feel more drowsy. If an overdose does occur, supportive care should be given. Keep these products out of reach of children, as taking too much by mouth can be dangerous. The toxic dose in rats was found to be 580 mg/kg.

image of a doctor in a lab doing drug, clinical research

Astepro Novel Uses: Which Conditions Have a Clinical Trial Featuring Astepro?

Currently, 9 active trials are assessing the potential of Astepro for Intranasal Administration, Ocular Disorders and Allergic Blepharitis.

Condition

Clinical Trials

Trial Phases

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Administration, Intranasal

0 Actively Recruiting

Keratoconjunctivitis

0 Actively Recruiting

Hay Fever

0 Actively Recruiting

Allergy to Tree Pollen

0 Actively Recruiting

Allergic Conjunctivitis (AC)

1 Actively Recruiting

Phase 2

Rhinitis, Allergic

0 Actively Recruiting

allergic eye disorders

0 Actively Recruiting

Blepharitis allergic

0 Actively Recruiting

Astepro Reviews: What are patients saying about Astepro?

5

Patient Review

11/16/2013

Astepro for Inflammation of the Nose due to an Allergy

This medication has been key in helping me get a better night's sleep.

5

Patient Review

9/20/2022

Astepro for Vasomotor Rhinitis

I used to use Afrin, but it stopped working for me. I switched to Azelestine and I've been much happier ever since. It's cheaper over the counter than with a prescription, and it keeps the drainage from making me cough all the time. No more morning coughing fits! I love this stuff. Yes, there is an after-taste for a while, but it's so worth it. I can tell when I miss a dose.

5

Patient Review

1/7/2013

Astepro for Inflammation of the Nose due to an Allergy

This treatment is effective, but it's not worth the price tag.

4.3

Patient Review

9/17/2012

Astepro for Seasonal Runny Nose

This treatment can cause some initial sneezing and blowing of the nose, as well as the need to clear heavy drainage from the throat and nose. However, after that it is easier to breathe.

3.7

Patient Review

10/2/2012

Astepro for Inflammation of the Nose due to an Allergy

Unfortunately, this made me incredibly sick to my stomach. The taste it left in my mouth was awful and no matter what I did, I couldn't get rid of it. Consequently, I wasted the entire $40 bottle.

3.3

Patient Review

8/18/2022

Astepro for Inflammation of the Nose due to an Allergy

This medication has been effective in reducing my drip, though it has made me very drowsy. I'll have to experiment with taking it at different times of day to see if that makes a difference.

2.7

Patient Review

4/5/2014

Astepro for Inflammation of the Nose due to an Allergy

This medication is difficult to administer as it runs down the back of your throat. In addition, the taste is incredibly unpleasant and lingers for a while. It also takes quite some time for the treatment to take effect. Overall, I would not recommend this product.

2.3

Patient Review

12/6/2013

Astepro for Vasomotor Rhinitis

I got pretty drowsy after each application, even though I only used one spray per nostril.

2

Patient Review

5/21/2014

Astepro for Inflammation of the Nose due to an Allergy

This medication really burns my nose and I get a terrible drip in the back of my throat, even when I follow the directions. The relief doesn't last long, but I continue to use it until my next appointment.

2

Patient Review

9/18/2022

Astepro for Non-Seasonal Allergic Runny Nose

I found that this treatment made me more stuffed up than before, and the aftertaste was incredibly unpleasant. Even after 24 hours, I still couldn't get rid of it.

1.7

Patient Review

10/11/2022

Astepro for Inflammation of the Nose due to an Allergy

I would not recommend this treatment, as it did nothing to help me with my congestion issues. Additionally, it tasted quite bad.

1.3

Patient Review

8/7/2022

Astepro for Seasonal Runny Nose

I had a week-long nosebleed that didn't help my allergies. Overall, not worth it and I regret using the product.

1.3

Patient Review

8/18/2022

Astepro for Seasonal Runny Nose

The intense, lingering bitter taste ruined my breakfast and lunch. I tried everything to get rid of it--mint gum, sweets, salty foods, spicy foods--to no avail. Furthermore, this treatment made me drowsy. Never again!

1

Patient Review

8/7/2022

Astepro for Seasonal Runny Nose

Unfortunately, this medication made me sneeze and my nose bleed.

1

Patient Review

10/9/2022

Astepro for Inflammation of the Nose due to an Allergy

The taste is incredibly bitter and lingers for far too long. I can't tell if it actually helped with my allergies because the taste was so bad.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about astepro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Astepro the same as azelastine?

"The drug Astepro is also known by its generic name, Azelastine. This drug is available in two different strengths, 0.1% and 0.15%. The 0.15% strength is the one that is available over-the-counter. Astepro OTC is a nasal antihistamine similar to drugs like Claritin, Allegra, Benadryl and Zyrtec, but it is applied topically to the nose instead of being ingested."

Answered by AI

What is Astepro nasal spray used for?

"Azelastine is used to treat the symptoms of allergies such as runny nose, itchy nose, stuffed nose, sneezing, and post-nasal drip. Azelastine belongs to a class of drugs called antihistamines."

Answered by AI

Is Astepro the same as Flonase?

"Astepro is a nasal spray that can help with allergy or nasal symptoms while Flonase is a good first-choice treatment for allergies of the nose but has a long-term risk of nosebleeds."

Answered by AI

When will Astepro be available?

"Bayer Healthcare estimates that Astepro will be available for over-the-counter purchase in retail locations at the beginning of 2022."

Answered by AI

Clinical Trials for Astepro