Astepro

Blepharitis allergic, Rhinitis, Vasomotor, Hay Fever + 6 more
Treatment
2 Active Studies for Astepro

What is Astepro

AzelastineThe Generic name of this drug
Treatment SummaryAzelastine is a medication used to treat allergies and swelling in the nose. It comes in a nasal spray and an eye drop form, and was first approved by the FDA in 1996. Azelastine is also available as a combination nasal spray with fluticasone propionate, called Dymista, which can be used to treat seasonal allergies in patients 6 years of age and older.
Astelinis the brand name
image of different drug pills on a surface
Astepro Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Astelin
Azelastine
1996
56

Effectiveness

How Astepro Affects PatientsAzelastine blocks histamine, reducing symptoms of allergies. It starts working within 15 minutes when taken as a nasal spray, or 3 minutes when used as eye drops. Its effects can last up to 12 hours.
How Astepro works in the bodyAzelastine is a drug used to treat allergies. It works by blocking histamine receptors in the body that cause allergy symptoms such as itching, sneezing, and congestion. It also has the ability to stabilize mast cells so they can't release inflammatory molecules, and it reduces the production of leukotrienes and other substances that cause inflammation. Finally, it can reduce levels of substance P and bradykinin in nasal secretions, which cause nasal itching and sneezing.

When to interrupt dosage

The suggested portion of Astepro is contingent upon the diagnosed situation, including Hay Fever, Disorder of eye and Keratoconjunctivitis. The measure of dosage differs, as per the mode of delivery (e.g. Nasal or Solution / drops) featured in the table beneath.
Condition
Dosage
Administration
Keratoconjunctivitis
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Administration, Intranasal
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
allergic eye disorders
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Rhinitis, Vasomotor
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Blepharitis allergic
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Rhinitis, Allergic
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Allergy to Tree Pollen
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Hay Fever
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic
Allergic Conjunctivitis (AC)
, 0.137 mg, 0.5 mg/mL, 0.2055 mg, 1.37 mg/mL, 1.0 mg/mL, 1.5 mg/mL, 0.137 mg/pump actuation
, Nasal, Spray, metered, Spray, metered - Nasal, Intraocular, Solution / drops, Solution / drops - Intraocular, Spray - Nasal, Spray, Ophthalmic, Solution / drops - Ophthalmic

Warnings

There are 20 known major drug interactions with Astepro.
Common Astepro Drug Interactions
Drug Name
Risk Level
Description
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Azelastine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Azelastine.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Azelastine.
Astepro Toxicity & Overdose RiskTaking too much azelastine through the nose or eyes is unlikely to cause serious side effects, but can make you feel more drowsy. If an overdose does occur, supportive care should be given. Keep these products out of reach of children, as taking too much by mouth can be dangerous. The toxic dose in rats was found to be 580 mg/kg.
image of a doctor in a lab doing drug, clinical research

Astepro Novel Uses: Which Conditions Have a Clinical Trial Featuring Astepro?

Currently, 9 active trials are assessing the potential of Astepro for Intranasal Administration, Ocular Disorders and Allergic Blepharitis.
Condition
Clinical Trials
Trial Phases
Rhinitis, Vasomotor
0 Actively Recruiting
Administration, Intranasal
0 Actively Recruiting
Keratoconjunctivitis
0 Actively Recruiting
Hay Fever
0 Actively Recruiting
Allergy to Tree Pollen
0 Actively Recruiting
Allergic Conjunctivitis (AC)
2 Actively Recruiting
Phase 3
Rhinitis, Allergic
0 Actively Recruiting
allergic eye disorders
0 Actively Recruiting
Blepharitis allergic
0 Actively Recruiting

Astepro Reviews: What are patients saying about Astepro?

5Patient Review
11/16/2013
Astepro for Inflammation of the Nose due to an Allergy
This medication has been key in helping me get a better night's sleep.
5Patient Review
9/20/2022
Astepro for Vasomotor Rhinitis
I used to use Afrin, but it stopped working for me. I switched to Azelestine and I've been much happier ever since. It's cheaper over the counter than with a prescription, and it keeps the drainage from making me cough all the time. No more morning coughing fits! I love this stuff. Yes, there is an after-taste for a while, but it's so worth it. I can tell when I miss a dose.
5Patient Review
1/7/2013
Astepro for Inflammation of the Nose due to an Allergy
This treatment is effective, but it's not worth the price tag.
4.3Patient Review
9/17/2012
Astepro for Seasonal Runny Nose
This treatment can cause some initial sneezing and blowing of the nose, as well as the need to clear heavy drainage from the throat and nose. However, after that it is easier to breathe.
3.7Patient Review
10/2/2012
Astepro for Inflammation of the Nose due to an Allergy
Unfortunately, this made me incredibly sick to my stomach. The taste it left in my mouth was awful and no matter what I did, I couldn't get rid of it. Consequently, I wasted the entire $40 bottle.
View All Reviews
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Patient Q&A Section about astepro

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Astepro the same as azelastine?

"The drug Astepro is also known by its generic name, Azelastine. This drug is available in two different strengths, 0.1% and 0.15%. The 0.15% strength is the one that is available over-the-counter. Astepro OTC is a nasal antihistamine similar to drugs like Claritin, Allegra, Benadryl and Zyrtec, but it is applied topically to the nose instead of being ingested."

Answered by AI

What is Astepro nasal spray used for?

"Azelastine is used to treat the symptoms of allergies such as runny nose, itchy nose, stuffed nose, sneezing, and post-nasal drip. Azelastine belongs to a class of drugs called antihistamines."

Answered by AI

Is Astepro the same as Flonase?

"Astepro is a nasal spray that can help with allergy or nasal symptoms while Flonase is a good first-choice treatment for allergies of the nose but has a long-term risk of nosebleeds."

Answered by AI

When will Astepro be available?

"Bayer Healthcare estimates that Astepro will be available for over-the-counter purchase in retail locations at the beginning of 2022."

Answered by AI

Clinical Trials for Astepro

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