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What is Amaryl
GlimepirideThe Generic name of this drug
Treatment SummaryGlimepiride is a prescription drug used to treat type 2 diabetes. It was first approved by the FDA in 1995 and is classified as a second-generation sulfonylurea medication. Glimepiride works by stimulating the release of insulin from the pancreas, which helps lower blood sugar levels. Compared to other sulfonylurea drugs, glimepiride has a longer duration of action, is associated with a lower risk of developing hypoglycemia and weight gain, and has fewer cardiovascular side effects. Glimepiride is usually taken once daily and is sold under the brand name Amaryl.
Amarylis the brand name
Amaryl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Amaryl
Glimepiride
2000
269
Approved as Treatment by the FDA
Glimepiride, otherwise known as Amaryl, is approved by the FDA for 7 uses which include Sulfonylurea Compounds and Physical Activity .Sulfonylurea Compounds
Used to treat prior thiazolidinedione and sulfonylurea treatment in combination with Pioglitazone
Physical Activity
Used to treat Exercise in combination with Pioglitazone
Type 2 Diabetes
Used to treat Type 2 Diabetes Mellitus in combination with Pioglitazone
Diet
Used to treat Diet in combination with Pioglitazone
inadequate response to monotherapy
Used to treat inadequate response to monotherapy in combination with Pioglitazone
Inadequate Glucose Control
Used to treat Inadequate Glucose Control in combination with Metformin
Inadequate Glycaemic Control
Used in combination with Insulin glargine to help manage Inadequate Glycaemic Control
Effectiveness
How Amaryl Affects PatientsGlimepiride helps the pancreas to produce more insulin, and improves the body's response to insulin so that it can absorb more glucose from the blood. This helps to reduce blood sugar levels and glycated hemoglobin (HbA1C). In clinical trials, individuals taking glimepiride saw their fasting plasma glucose drop by 46 mg/dL, post-prandial glucose (PPG) drop by 72 mg/dL, and HbA1c drop by 1.4% compared to those taking a placebo. Additionally, higher doses of glimepiride were found to be more effective than lower doses
How Amaryl works in the bodyGlimepiride works by blocking potassium channels on the cells that make insulin in the pancreas. These channels normally open when there is low ATP (energy) in the cell and close when there is more ATP. When the potassium channels open, they cause the cell to become more negative, which stops the release of insulin. When glimepiride blocks the channels, it stops them from opening and allows insulin release to continue. Glimepiride also binds to another part of the channel to promote more insulin release from the cell.
When to interrupt dosage
The recommended dose of Amaryl is contingent upon the recognized affliction, including Type 2 Diabetes, Sulfonylurea Compounds and Diet. The amount likewise changes as per the technique of delivery (e.g. Tablet or Oral) provided in the table beneath.Condition
Dosage
Administration
Inadequate Glucose Control
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Physical Activity
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Inadequate Glycaemic Control
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Sulfonylurea Compounds
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Type 2 Diabetes
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
inadequate response to monotherapy
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Diet
, 1.0 mg, 4.0 mg, 2.0 mg, 3.0 mg, 6.0 mg, 8.0 mg
, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral
Warnings
Amaryl ContraindicationsCondition
Risk Level
Notes
Type 1 Diabetes
Do Not Combine
allergic reaction to sulfonamide derivatives
Do Not Combine
Diabetic Ketoacidosis
Do Not Combine
Common Amaryl Drug Interactions
Drug Name
Risk Level
Description
(R)-warfarin
Minor
Glimepiride may increase the anticoagulant activities of (R)-warfarin.
(S)-Warfarin
Minor
Glimepiride may increase the anticoagulant activities of (S)-Warfarin.
Abrocitinib
Minor
The metabolism of Abrocitinib can be decreased when combined with Glimepiride.
Alosetron
Minor
The metabolism of Alosetron can be decreased when combined with Glimepiride.
Amprenavir
Minor
The metabolism of Amprenavir can be decreased when combined with Glimepiride.
Amaryl Toxicity & Overdose RiskGlimepiride has a low toxicity in rats, with the highest dose having no effect. When taken in high doses for 24 months, mice had an increased chance of developing benign tumors in the pancreas. Glimepiride was not found to have any mutagenic effects and did not affect fertility in rats. In the case of an overdose, severe hypoglycemia with coma, seizures, or other neurological impairment may occur. This can be treated with glucagon or intravenous glucose.
Amaryl Novel Uses: Which Conditions Have a Clinical Trial Featuring Amaryl?
196 active investigations are being conducted to assess the potential of Amaryl to treat Type 2 Diabetes, Sulfonylurea Compounds and improve Physical Activity.Condition
Clinical Trials
Trial Phases
Physical Activity
38 Actively Recruiting
Not Applicable, Phase 2, Phase 1, Early Phase 1
Type 2 Diabetes
192 Actively Recruiting
Phase 2, Not Applicable, Early Phase 1, Phase 1, Phase 4, Phase 3
inadequate response to monotherapy
0 Actively Recruiting
Inadequate Glucose Control
0 Actively Recruiting
Inadequate Glycaemic Control
0 Actively Recruiting
Diet
5 Actively Recruiting
Not Applicable
Sulfonylurea Compounds
0 Actively Recruiting
Amaryl Reviews: What are patients saying about Amaryl?
5Patient Review
5/30/2016 Metformin was becoming ineffective for me and I was constantly nauseous and had diarrhea. Switching to Glemiperide has been a life-saver as my blood sugar is now normal and I don't have any abdominal issues.
5Patient Review
11/16/2012 When I first started this medication, it was effective if I exercised after taking it. However, now there seems to be no difference in how my body responds regardless of how active my day is.
5Patient Review
6/13/2013 I started taking this medication this morning, and two hours later my sugar levels had already dropped. I'm really impressed!
4.7Patient Review
10/15/2013 My doctors initially had me on too high of a dose, so I was experiencing a lot of low blood sugar levels. We've since changed my dosage to 1 mg in the morning and 1 mg with dinner, which has helped immensely. I've also completely changed my diet and lost 7 pounds. I'm still tired, but doing better overall. My numbers dropped from 340 to 122 on average within two weeks.
4.3Patient Review
10/30/2012 I've only just started using this medication, but so far it's been working well.
4Patient Review
10/15/2013 This medication has been controlling my blood sugar levels, but one of the doctors I've seen recently suggests that I switch to insulin. I'm not happy about this. He says that the Glimepiride is causing damage to the pancreatic cells. What do you think?
4Patient Review
4/4/2014 My experience with this treatment was good. It met my expectations.
4Patient Review
1/15/2013 I experienced cramping and shaking, as well as a lack of energy.
3.3Patient Review
4/2/2019 Yes, it's easy to use this medication, but on busy days when I'm struggling to eat enough carbs, my blood sugar can still drop low. It's effective in general, but you have to be careful with it.
3.3Patient Review
1/12/2014 I've been taking this pill for the past ten days as prescribed (half a tablet in the morning and half at night). My blood levels have gone back to normal, but I've experienced some pretty intense side effects like low sugar levels, increased heart rate, shaking nerves, and sweating. Despite all of that, my doctor says I should continue taking the pill.
3.3Patient Review
1/31/20123Patient Review
8/7/2012 I had a really bad reaction when my dosage was increased. I got hives all over my body that lasted for months. Once I finally stopped taking the medicine, the hives were gone within just a few days.
3Patient Review
2/3/2013 dieting, exercising, and other diabetes treatments didn't work for me until I was prescribed this medication. It's been really effective with no negative side effects that I've noticed.
3Patient Review
2/15/20122.7Patient Review
2/9/2013 While this medication does help to regulate blood sugar levels, it unfortunately also causes erectile dysfunction.
1Patient Review
2/6/2015 Unfortunately, this medication did not work for me. My sugar levels are still high, and I experience drowsiness and forgetfulness after taking it.
Patient Q&A Section about amaryl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Can you take Amaryl and metformin together?
"It is common for people with type 2 diabetes to take both Amaryl (glimepiride) and metformin to lower their blood sugar levels."
Answered by AI
When is the best time to take Amaryl?
"Amaryl should be taken with breakfast or the first main meal of the day. The recommended starting dose of Amaryl is 1 mg or 2 mg once daily."
Answered by AI
What is Amaryl used for?
"Glimepiride is used to help control blood sugar levels in people with type 2 diabetes. Keeping blood sugar levels under control can help prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems."
Answered by AI
What are the side effects of Amaryl?
"There are a variety of symptoms that can come with ingesting something that your body is adverse to. These can include feeling nauseous, having an upset stomach, stomach pain, vomiting, diarrhea, dizziness, headaches, and feeling tired."
Answered by AI