UPMC-Presbyterian Hospital

Summary

UPMC-Presbyterian Hospital is a medical facility located in Pittsburgh, Pennsylvania. This center is recognized for care of Breast Cancer, Lung Cancer, Stroke, Breast cancer, Heart Failure and other specialties. UPMC-Presbyterian Hospital is involved with conducting 306 clinical trials across 544 conditions. There are 33 research doctors associated with this hospital, such as Liza C. Villaruz, Dan P. Zandberg, Pablo Sanchez, MD, and Ibrahim Sultan, MD.

Top PIs

Clinical Trials running at UPMC-Presbyterian Hospital

Stroke

Lung Cancer

Heart Disease

Laryngeal Cancer

Colon Cancer

Cardiovascular Disease

Heart Failure

Valvular Heart Disease

Brain Tumor

Oropharyngeal Carcinoma

Sovateltide

for Stroke

Extensive research is being conducted in search of neuroprotective agents for possible use in the acute phase of stroke and agents that can be used for neurorepair in later stages of stroke. Several trials have been conducted and are in progress using different pharmacological agents, but none of the studies involve the stimulation of ETB receptors to treat cerebral ischemic stroke. Sovateltide (IRL-1620, PMZ-1620) has been effective in animal models of cerebral ischemic stroke. Its safety and tolerability have been demonstrated in a human phase I study with 7 subjects. Clinical phase II and III results indicate that sovateltide is a novel, first-in-class, highly effective drug candidate for treating cerebral ischemic stroke. Safety and significant efficacy in improving the National Institutes of Health Stroke Scale (NIHSS), Modified Rankin scale (mRS), and Barthel index (BI) obtained in phase II and III studies in patients with cerebral ischemic stroke in India are convincing and encouraged us to investigate its safety and efficacy in cerebral ischemic stroke patients in the United States. Therefore, the plan is to conduct a phase III clinical study to evaluate the safety and efficacy of sovateltide therapy along with standard of care in patients of acute ischemic stroke.

Recruiting

2 awards

Phase 3

3 criteria

Endovascular Thrombectomy

for Stroke

STEP is a Randomized, Multifactorial, Adaptive Platform trial that seeks to optimize the care of patients with acute ischemic stroke (AIS) due to large (LVO) or medium vessel occlusions (MVO).

Recruiting

1 award

N/A

2 criteria

Transcranial Magnetic Stimulation

for Stroke

VERIFY will validate biomarkers of upper extremity (UE) motor outcome in the acute ischemic stroke window for immediate use in clinical trials, and explore these biomarkers in acute intracerebral hemorrhage. VERIFY will create the first multicenter, large-scale, prospective dataset of clinical, transmagnetic stimulation (TMS), and MRI measures in the acute stroke time window.

Recruiting

1 award

N/A

6 criteria