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Magee Women's Hospital of UPMC

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Pittsburgh, Pennsylvania 15213

Global Leader in Breast Cancer

Global Leader in Ovarian Cancer

Conducts research for Breast cancer

Conducts research for Fallopian Tube Cancer

Conducts research for Cancer

403 reported clinical trials

44 medical researchers

Photo of Magee Women's Hospital of UPMC in PittsburghPhoto of Magee Women's Hospital of UPMC in PittsburghPhoto of Magee Women's Hospital of UPMC in Pittsburgh

Summary

Magee Women's Hospital of UPMC is a medical facility located in Pittsburgh, Pennsylvania. This center is recognized for care of Breast Cancer, Ovarian Cancer, Breast cancer, Fallopian Tube Cancer, Cancer and other specialties. Magee Women's Hospital of UPMC is involved with conducting 403 clinical trials across 537 conditions. There are 44 research doctors associated with this hospital, such as Adam Brufsky, MD, Melissa A. Burgess, Alexander B. Olawaiye, and Adam Olson.

Area of expertise

1

Breast Cancer

Global Leader

Magee Women's Hospital of UPMC has run 92 trials for Breast Cancer. Some of their research focus areas include:

HER2 negative
ER positive
Stage IV
2

Ovarian Cancer

Global Leader

Magee Women's Hospital of UPMC has run 53 trials for Ovarian Cancer. Some of their research focus areas include:

Stage IV
Stage III
BRCA1 positive

Top PIs

Clinical Trials running at Magee Women's Hospital of UPMC

Breast Cancer

Ovarian Cancer

Cancer

Prostate Cancer

Breast cancer

Endometrial Cancer

Testicular cancer

Small Cell Lung Cancer

Pre-eclampsia

Oral Squamous Cell Carcinoma

Image of trial facility.

Contrast-Enhanced Mammography

for Breast Abnormalities

One of the primary criticisms of mammography is that it leads to unneeded stress and anxiety from identification and biopsy of non-cancerous findings. Contrast-enhanced mammography (CEM) has the potential to significantly reduce biopsy rates for commonly seen benign breast lesions while preserving very high cancer detection. The investigators propose a prospective clinical study of patients with diagnostic mammograms rated as BIRADS 4A or 4B and scheduled for a biopsy, in which, prior to undergoing their scheduled biopsy, a CEM procedure is performed. The investigators will test the primary hypothesis that for soft tissue lesions (i.e. masses, asymmetries, architectural distortions) initially rated BI-RADS 4A/4B adding CEM will reduce, by at least 20%, the number of biopsy recommendations for actually benign cases and, at the same time, provide a negative predictive value (NPV) higher than 95%.

Recruiting

3 awards

Phase 4

3 criteria

Image of trial facility.

Chemotherapy + Hormone Therapy

for Breast Cancer

This trial is testing if adding additional cancer-fighting drugs to treatments that stop certain body functions is better than just using the treatments that stop those functions alone. It targets younger women with early-stage breast cancer who have a higher risk of dying from the disease. The treatment works by stopping certain body functions and using drugs to kill cancer cells.

Recruiting

2 awards

Phase 3

19 criteria

Image of trial facility.

Durvalumab + Chemotherapy

for Breast Cancer

This phase III trial compares the addition of an immunotherapy drug (durvalumab) to usual chemotherapy versus usual chemotherapy alone in treating patients with MammaPrint High 2 Risk (MP2) stage II-III hormone receptor positive, HER2 negative breast cancer. Immunotherapy with monoclonal antibodies, such as durvalumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Chemotherapy drugs, such as paclitaxel, doxorubicin, and cyclophosphamide work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. There is some evidence from previous clinical trials that people who have a MammaPrint High 2 Risk result may be more likely to respond to chemotherapy and immunotherapy. Adding durvalumab to usual chemotherapy may be able to prevent the cancer from returning for patients with MP2 stage II-III hormone receptor positive, HER2 negative breast cancer.

Recruiting

2 awards

Phase 3

40 criteria

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