Violence Intervention Program for Gunshot Wounds

(MS-VIP Trial)

Overseen By Masoumeh Karimi, PHD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Mississippi Medical Center

Disqualifiers: Self-inflicted wounds, Incarceration, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

500 Participants Needed

Trial Summary

Do I have to stop taking my current medications for this trial?

The trial protocol does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Hospital-Linked Violence Intervention Program, Mobile Community Event Support, Unrestricted Cash Assistance for gunshot wounds?

Research suggests that hospital-based violence intervention programs (HVIPs) can improve outcomes for individuals with firearm injuries by providing intensive, community-based support, which may reduce the risk of violent reinjury and improve recovery. Additionally, these programs are seen as beneficial in addressing the public health issue of gun violence by creating strong partnerships between hospitals and communities. ^{1 2 3 4 5}

Is the Violence Intervention Program for Gunshot Wounds safe for humans?

The available research does not provide specific safety data for the Violence Intervention Program for Gunshot Wounds, but it suggests that hospital-based violence intervention programs are generally aimed at improving patient outcomes through community support and case management. ^{1 2 5 6 7}

How is the Violence Intervention Program for Gunshot Wounds treatment different from other treatments?

This treatment is unique because it combines hospital-linked violence intervention with community support and unrestricted cash assistance, focusing on both immediate and long-term recovery for gunshot wound survivors. It addresses not just the physical injury but also the social and economic factors that contribute to violence, which is different from standard medical treatments that focus solely on physical healing. ^{1 5 8 9 10}

What is the purpose of this trial?

This clinical trial is designed to evaluate the effectiveness of three interventions aimed at preventing violence and supporting those affected by it. Over next three years, the impact of these interventions on key areas will be measured, including the incidence of firearm injuries, the recovery of victims, the occurrence of retaliation and re-injury, and health economics. The interventions are developed based on data collected from a comprehensive needs assessment, community summit, retrospective medical chart reviews, and focus group sessions. The defined interventions are as follows: Intervention A - Integration of an existing community-based intervention program with Hospital services intervention B - Unrestricted Cash Assistance Intervention C - Mobile Community Support Services Additionally, the investigators will implement a detailed violence-focused survey for firearm survivors at the time of study enrollment. Follow-up is planned at 3,6 and 12 months. The results of this trial (including analyses of firearm injury rates, recovery outcomes, retaliation/re-injury occurrences, and economic data) will be shared with the affected communities and stakeholders to promote ongoing improvement and support.

Research Team

Lei Zhang, PHD

Principal Investigator

Associate Dean For Research And Scholarship

Eligibility Criteria

This trial is for individuals affected by gun violence, specifically those who have suffered a gunshot wound. The study aims to support their recovery and prevent further incidents of violence. Participants will be involved in the program over three years and must be willing to complete surveys at enrollment and follow-ups.

Inclusion Criteria

Firearm injury within the last 24 hours prior to their arrival at the University of Mississippi Medical Center

The research team contacted me within 3 days of my arrival.

I can understand the trial details, sign the consent, and attend all follow-ups.

Exclusion Criteria

I am able to understand and consent to the clinical trial.

Self-inflicted gunshot wounds

Patients unable to commit to follow-up or be contacted through routine means

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention

Implementation of community-focused interventions including Unrestricted Cash Assistance, Mobile Community Support Services, and Operation Good

3 years

Ongoing community and hospital-based interactions

Follow-up

Participants are monitored for safety and effectiveness after intervention, with follow-up surveys at 3, 6, and 12 months

3 years

Follow-up surveys at 3, 6, and 12 months

Treatment Details

Interventions

• Hospital-Linked Violence Intervention Program
• Mobile Community Event Support
• Unrestricted Cash Assistance

Trial Overview The effectiveness of three interventions: a hospital-linked community program, unrestricted cash assistance, and mobile community event support are being tested. These aim to reduce firearm injuries, aid victim recovery, minimize retaliation/re-injury rates, and assess health economics impact.

Participant Groups

Group I: Active Arm Experimental Treatment 3 Interventions

Intervention: It includes three key components: 1. Unrestricted Cash Assistance provided to individuals to support their immediate needs, 2. Mobile Community Support Services that offer on-site assistance and resources, and 3. Activation of Operation Good with coordination between hospital and community services to ensure seamless support for individuals affected by violence, promoting recovery and reducing the risk of re-injury or retaliation.

Group II: In-Active Arm Active Control 1 Intervention

This group will receive no intervention beyond the standard care provided in the hospital setting. No additional services, cash assistance, or community-based support will be offered. This arm will serve as a comparison group to evaluate the effectiveness of the intervention.

Who Is Running the Clinical Trial?

University of Mississippi Medical Center

Lead Sponsor

Trials

185

Recruited

200,000+

National Institutes of Health (NIH)

Collaborator

Trials

2,896

Recruited

8,053,000+

National Institute on Minority Health and Health Disparities (NIMHD)

Collaborator

Trials

473

Recruited

1,374,000+

Findings from Research

The Prescription for Hope (RxH) program significantly reduced the odds of violent reinjury among participants, with a 65% lower chance of being reinjured after a violent incident, based on a study of 992 patients over a 2-year period.

However, participation in RxH was also associated with increased odds of new convictions for violent crime, suggesting that while the program may help prevent further injuries, it may not address underlying issues related to violent behavior.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Violent injury prevention does not equal to violent crime prevention: an analysis of violence intervention program efficacy using propensity score methods. Holler Mph, E., Ortiz Md, D., Mohanty Md Ms, S., et al.[2022]

The CeaseFire program, which integrates hospital resources with community violence interrupters, aims to reduce penetrating trauma rates in a specific area (zip code 70113) by providing support from the moment of injury through recovery and community reintegration.

While the overall incidence of penetrating trauma in Orleans Parish increased during the study period, the target area (70113) experienced a slower rate of increase compared to adjacent zip codes, suggesting that the program may have a positive impact on violence reduction over time.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Operation CeaseFire-New Orleans: an infectious disease model for addressing community recidivism from penetrating trauma. McVey, E., Duchesne, JC., Sarlati, S., et al.[2014]

References

1. England pubmed.ncbi.nlm.nih.gov

Barriers to recruitment, retention and intervention delivery in a randomized trial among patients with firearm injuries. [2022]

2. Netherlands pubmed.ncbi.nlm.nih.gov

Positioning public health surveillance for observational studies and clinical trials: The St. Louis region-wide hospital-based violence intervention program data repository. [2022]

3. England pubmed.ncbi.nlm.nih.gov

Violent injury prevention does not equal to violent crime prevention: an analysis of violence intervention program efficacy using propensity score methods. [2022]

4. England pubmed.ncbi.nlm.nih.gov

An exploration of factors impacting implementation of a multisystem hospital-based violence intervention program. [2023]

5. England pubmed.ncbi.nlm.nih.gov

Implementation of an emerging hospital-based violence intervention program: a multimethod study. [2023]

6. United States pubmed.ncbi.nlm.nih.gov

Gun Violence and Firearm Injuries in West Michigan: Targeting Prevention. [2022]

7. United States pubmed.ncbi.nlm.nih.gov

Race Impacts Outcomes of Patients With Firearm Injuries. [2021]

8. United States pubmed.ncbi.nlm.nih.gov

Mechanism of penetrating injury mediates the risk of long-term adverse outcomes for survivors of violent trauma. [2023]

9. United States pubmed.ncbi.nlm.nih.gov

Violence Perpetration Among Patients Hospitalized for Unintentional and Assault-Related Firearm Injury: A Case-Control Study and a Cohort Study. [2022]

10. United States pubmed.ncbi.nlm.nih.gov

Operation CeaseFire-New Orleans: an infectious disease model for addressing community recidivism from penetrating trauma. [2014]