This trial is evaluating whether Treatment will improve 1 primary outcome and 12 secondary outcomes in patients with Hernia, Inguinal. Measurement will happen over the course of 30 days post-operative.
This trial requires 280 total participants across 1 different treatment groups
This trial involves a single treatment. Treatment is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
Around 2 million Americans develop hernia each year. The peak age for herniated inguinal wall is 30 to 39 years. Men are more prone to hernia than women. This hernia affects the abdominal cavity and can extend to the scrotum. This hernia has an overall mortality rate of 0.1%. Hernia is a common problem among patients presenting with abdominal pain. Laparoscopic mesh repair is the treatment of choice.
Most inguinal hernias occur in children. There are 2 types of hernias and they differ in symptoms and treatment strategies. The common hernia has 4 layers and is called paramesomphalicus and parieto-imperitoneal. The mesh surgery for paramesomphalic hernia can be performed using the minimally invasive laparoscopy. Treatment options for parieto-imperitoneal hernia are mesh surgery, hernia prophylaxis with propranolol (beta blocker), and inguinal hernia prophylaxis using a periurethral mesh patch (ProSeal). (c) 2007 Wiley-Liss, Inc.
Hernia, inguinal, is not a common disorder. The mainstay of management for the patients is surgical repair with mesh. If the mesh is not available then surgical mesh-placement can be done even if the mesh is in moderate to severe degenerative states, by applying a bio-absorbable mesh.
Possible symptoms of hernia include vomiting (early in the course of the illness), pain in the left lower quadrant of the abdomen, inability to defecate, and swelling of the abdomen. Other symptoms are similar to those of an abdominal pain of other aetiology (gall bladder, gastritis, diverticulitis, appendicitis), as well as inguinal hernias due to an abdominal pathology. Imaging of the abdomen is of great importance. Radiographs, CT and, if possible, MRI, are the most indicated scans.
In the present series some cases could not be explained fully; the causes of hernia are probably multicomponent. The main predisposing factor is male sex, which explains 50% of cases of inguinal hernia. The only identifiable predisposing factor in the control population was a family member with inguinal hernia. In addition, obesity may be a predisposing factor for inguinal hernia; however, this need to have a more thorough investigation, to define the underlying factors contributing to this condition. As obese males are not found to have a higher incidence of developing hernia, obesity alone cannot be the cause of hernia.
There is potential for improvement in the current hernia paradigm. Current inguinal hernia surgery does not have a cure rate in excess of 55%-60%, although these figures have not been properly reported. There is potential for inguinal hernia therapy to be cure oriented.
We recommend spermiogenesis be suspected when inguinal hernias occur in elderly patients with no medical history. We also recommend repairing the hernias if they occur with an unexplained inguinal pain or discomfort. The surgical management of hernias is highly specialized and we recommend careful follow-up.
The study shows that in more recent literature the procedure for surgical treatment of inguinal hernia is a complex algorithm, with a range of different surgical and non-surgical technical approaches. Different surgical approaches are related to the anatomical variants and pathological aspects of the disease. Inguinal hernia repair represents the only surgical approach which can guarantee a cure in all anatomical variants, even in complex cases.
Hernia involves the contents of the abdomen and can be very painful. Inguinal hernias account for approximately 2% of inguinal hernias. Current medical literature does not exist to substantiate any clear guidelines for the referral of patients with inguinal and/or abdominal Hernia, to clinical trials. Therefore, it is recommended that consideration of both surgical and medical aspects be considered when deciding on which clinical trials to pursue, and that all patients with inguinal hernias or abdominal hernias be referred for testing, regardless of location.
This review highlights the important role of clinical and clinical trial outcomes in safety appraisal and, therefore, the need to assess the safety of treatments more systematically and systematically.
Researchers are studying the effectiveness of different types of mesh material, and the potential causes of hernias. One study looked at the possibility of mesh material breaking up in the patient's body. Doctors will evaluate a number of hernias and discuss them with patients. A great deal of effort has gone into finding a mesh material that will work and will not create a complication. Other studies have focused on the effectiveness of different types of mesh material, and scientists have found a way to make hernia repairs safer as well as more effective. Patients need to make a decision based on the study results as well as their own experience. One of the best sites for information for hernia, inguinal repairs is the American Urological Association.
There are many new discoveries for treating hernia, inguinal, including the use of [a mesh(s) that are seeded or grown in the patient's own body, but are only inserted in the body's abdominal cavity to heal and to support the skin, muscle, and fascia rather than being removed and then re-implanted.] There has been a recent report from a New York Center about treating inguinal hernia--[using the [femoral patch-technique] invented in New Jersey by Dr. [Sebastian] Farfan and [Dr.] Eugene G.