Behavioral Memory Modulation for Nicotine Addiction
LW
SW
Overseen ByShannon Wnorowski
Age: 18+
Sex: Any
Travel: May Be Covered
Time Reimbursement: Varies
Trial Phase: Academic
Waitlist Available
Sponsor: Medical University of South Carolina
No Placebo Group
Trial Summary
What is the purpose of this trial?
The purpose of the study is to see if a behavioral intervention known as retrieval-extinction training (RET) might affect craving in response to nicotine cues (e.g., pictures, videos and objects) and smoking behavior in men and women who smoke cigarettes.
Research Team
MS
Michael Saladin, PhD
Principal Investigator
Medical University of South Carolina
Eligibility Criteria
This trial is for healthy adults aged 25-65 who have smoked at least 10 cigarettes daily for over 3 years. They must live within a 50-mile radius of the research site, have reliable transport, and not use other smoking cessation aids during the study. Participants should be willing to stop smoking before certain visits and stay smoke-free for four days.Inclusion Criteria
Participants must live within a 50-mile radius of the research facility and have reliable transportation.
You are a healthy adult between the ages of 25 and 65, and have a history of smoking at least 10 cigarettes per day for 3 years or more.
Participants must agree to forego any other medication or behavioral treatment for smoking cessation while enrolled in the study (with the exception of the SC Quitline).
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Exclusion Criteria
You cannot participate if you are addicted to any substances other than nicotine.
Women who are pregnant during the clinical assessment session or either of the fMRI sessions. These participants must agree to notify the study staff if they become pregnant during the study.
Treatment Details
Interventions
- Control Retrieval Extinction Training (RET) (Behavioural Intervention)
- Retrieval Extinction Training (RET) (Behavioural Intervention)
Trial OverviewThe study tests if Retrieval Extinction Training (RET), a behavioral intervention, can reduce cravings and alter smoking behavior in response to nicotine cues. Some participants will undergo RET with fMRI scanning while others without it or may receive control treatments.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: R-E (Retrieval Extinction)Experimental Treatment1 Intervention
83 anticipated participants will undergo 3 sessions on consecutive days of the Retrieval Extinction Training (RET) intervention consisting of a 5-minute 'retrieval' smoking-content video followed 10 minutes later by 1 hour of 'extinction' training consisting of four sequences of smoking-related cues (e.g., pictures). Participants will also receive a lab-based smoking-related cue-reactivity experience during the baseline assessment and 24-hour follow-up test.
Group II: NR-E (No R-E)Experimental Treatment1 Intervention
83 anticipated participants will undergo 3 sessions on consecutive days of the control Retrieval Extinction Training (RET) intervention consisting of a 5-minute 'retrieval' non-smoking or neutral-content video followed 10 minutes later by 1 hour of 'extinction' training consisting of four sequences of non-smoking or neutral cues (e.g., pictures). Participants will also receive a lab-based non-smoking or neutral cue-reactivity experience during the baseline assessment and 24-hour follow-up test.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical University of South Carolina
Lead Sponsor
Trials
994
Recruited
7,408,000+
National Institutes of Health (NIH)
Collaborator
Trials
2,896
Recruited
8,053,000+
National Institute on Drug Abuse (NIDA)
Collaborator
Trials
2,658
Recruited
3,409,000+