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Behavioral Memory Modulation for Nicotine Addiction

N/A
Waitlist Available
Led By Michael Saladin, PhD
Research Sponsored by Medical University of South Carolina
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up between week 1 and week 26
Awards & highlights

Summary

This trial will test a new method to help smokers quit by reducing cravings.

Who is the study for?
This trial is for healthy adults aged 25-65 who have smoked at least 10 cigarettes daily for over 3 years. They must live within a 50-mile radius of the research site, have reliable transport, and not use other smoking cessation aids during the study. Participants should be willing to stop smoking before certain visits and stay smoke-free for four days.Check my eligibility
What is being tested?
The study tests if Retrieval Extinction Training (RET), a behavioral intervention, can reduce cravings and alter smoking behavior in response to nicotine cues. Some participants will undergo RET with fMRI scanning while others without it or may receive control treatments.See study design
What are the potential side effects?
Since this trial involves behavioral training rather than medication, traditional side effects are not expected. However, participants might experience discomfort from abstaining from smoking or stress due to participation requirements like MRI scans.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~between week 1 and week 26
This trial's timeline: 3 weeks for screening, Varies for treatment, and between week 1 and week 26 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean Change in Blood Pressure
Mean Change in Heart Rate
Mean Change in Skin Conductance
+2 more

Side effects data

From 2022 Phase 2 trial • 182 Patients • NCT02966873
19%
Gastrointestinal Discomfort
16%
Viral Upper Respiratory Tract Infections (Cold)
10%
Nausea
10%
Injury
9%
Muscle or Joint Pain
5%
Flatulence
4%
Headache/Migraine
3%
Sinusitis
2%
Pneumonia
2%
Anxiety
2%
Constipation
1%
Stroke
1%
Sepsis
1%
Pancreatitis
1%
Bladder Infection
1%
Injury/Accident
100%
80%
60%
40%
20%
0%
Study treatment Arm
N-Acetylcysteine (NAC) Treatment Group
Placebo Group

Trial Design

4Treatment groups
Experimental Treatment
Group I: R-E (Retrieval Extinction) with no fMRIExperimental Treatment2 Interventions
49 anticipated participants will undergo 3 sessions on consecutive days of the Retrieval Extinction Training (RET) intervention consisting of a 5-minute 'retrieval' smoking-content video followed 10 minutes later by 1 hour of 'extinction' training consisting of four sequences of smoking-related cues (e.g., pictures). Participants will also receive a lab-based smoking-related cue-reactivity experience during the baseline assessment and 24-hour follow-up test that is equivalent to the task that the R-E with fMRI arm receives in the fMRI scanner. This arm participates in the no functional magnetic resonance imaging (fMRI) intervention.
Group II: R-E (Retrieval Extinction) with fMRIExperimental Treatment2 Interventions
34 anticipated participants will undergo 3 sessions on consecutive days of the Retrieval Extinction Training (RET) intervention consisting of a 5-minute 'retrieval' smoking-content video followed 10 minutes later by 1 hour of 'extinction' training consisting of four sequences of smoking-related cues (e.g., pictures). Participants will also receive a smoking-related cue-reactivity experience in an fMRI scanner during the baseline assessment and 24-hour follow-up test. This arm participates in the functional magnetic resonance imaging (fMRI) intervention.
Group III: NR-E (No R-E) with no fMRIExperimental Treatment2 Interventions
49 anticipated participants will undergo 3 sessions on consecutive days of the control Retrieval Extinction Training (RET) intervention consisting of a 5-minute 'retrieval' non-smoking or neutral-content video followed 10 minutes later by 1 hour of 'extinction' training consisting of four sequences of non-smoking or neutral cues (e.g., pictures). Participants will also receive a lab-based non-smoking or neutral cue-reactivity experience during the baseline assessment and 24-hour follow-up test that is equivalent to the task that the NR-E with fMRI arm receives in the fMRI scanner. This arm participates in the no functional magnetic resonance imaging (fMRI) intervention.
Group IV: NR-E (No R-E) with fMRIExperimental Treatment2 Interventions
34 anticipated participants will undergo 3 sessions on consecutive days of the control Retrieval Extinction Training (RET) intervention consisting of a 5-minute 'retrieval' non-smoking or neutral-content video followed 10 minutes later by 1 hour of 'extinction' training consisting of four sequences of non-smoking or neutral cues (e.g., pictures). Participants will also receive a non-smoking or neutral cue-reactivity experience in an fMRI scanner during the baseline assessment and 24-hour follow-up test. This arm participates in the functional magnetic resonance imaging (fMRI) intervention.

Find a Location

Who is running the clinical trial?

Medical University of South CarolinaLead Sponsor
947 Previous Clinical Trials
7,397,877 Total Patients Enrolled
1 Trials studying Nicotine Addiction
77 Patients Enrolled for Nicotine Addiction
National Institutes of Health (NIH)NIH
2,736 Previous Clinical Trials
7,507,759 Total Patients Enrolled
3 Trials studying Nicotine Addiction
327 Patients Enrolled for Nicotine Addiction
National Institute on Drug Abuse (NIDA)NIH
2,503 Previous Clinical Trials
2,625,392 Total Patients Enrolled
15 Trials studying Nicotine Addiction
2,130 Patients Enrolled for Nicotine Addiction

Media Library

Control Retrieval Extinction Training (RET) Clinical Trial Eligibility Overview. Trial Name: NCT03744559 — N/A
Nicotine Addiction Research Study Groups: R-E (Retrieval Extinction) with no fMRI, R-E (Retrieval Extinction) with fMRI, NR-E (No R-E) with no fMRI, NR-E (No R-E) with fMRI
Nicotine Addiction Clinical Trial 2023: Control Retrieval Extinction Training (RET) Highlights & Side Effects. Trial Name: NCT03744559 — N/A
Control Retrieval Extinction Training (RET) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03744559 — N/A
~30 spots leftby Jul 2025