Platelet Rich Plasma for Musculoskeletal Conditions

(PRP for MSK Trial)

Overseen By Jamie Egbert, MS

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Utah

Disqualifiers: Active malignancy, Platelet disorder, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 3

Duration: 1 day

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to assess the effects of platelet-rich plasma (PRP) injections on individuals with various musculoskeletal (MSK) conditions, such as knee osteoarthritis or rotator cuff issues. Researchers seek to determine if PRP can reduce pain, improve movement, and increase satisfaction over a year. Participants should have an MSK condition that has not improved with other treatments. Those experiencing joint or tendon pain that affects daily activities and have not found relief elsewhere may find this trial suitable. As an unphased trial, this study offers a unique opportunity to explore a promising treatment option that could enhance quality of life.

Do I need to stop my current medications for the trial?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that platelet rich plasma injections are safe for musculoskeletal conditions?

Research has shown that platelet-rich plasma (PRP) is generally safe for treating joint and muscle issues. Studies have found PRP to be a promising treatment with benefits for healing and regeneration. It is also considered safer than some other options, such as corticosteroids.

However, possible side effects include infections, swelling, allergic reactions, and small lumps forming under the skin. Although these side effects can occur, current research indicates that the overall risk is low. It is important to discuss potential risks with a healthcare provider before deciding to join a trial. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about Platelet Rich Plasma (PRP) injections for musculoskeletal conditions because they use a unique approach by harnessing the body's natural healing process. Unlike traditional treatments like physical therapy, medications, or surgery, PRP injections involve using a concentrated dose of a patient's own platelets, which are rich in growth factors that can accelerate tissue repair and reduce inflammation. This personalized method has the potential to improve recovery times and outcomes without the need for synthetic drugs or invasive procedures.

What evidence suggests that platelet rich plasma injection might be an effective treatment for musculoskeletal conditions?

Studies have shown that platelet-rich plasma (PRP) injections effectively reduce pain and improve movement in various muscle and joint conditions. For chronic plantar fasciitis, patients have experienced less pain and better movement. Research indicates that PRP significantly reduces pain at 6 and 12 months compared to treatments without PRP. In conditions like knee tendon pain, Achilles tendon pain, and tennis elbow, PRP has shown promising results, aiding in pain relief and improved movement. Overall, PRP is becoming a helpful treatment option for different joint and tendon problems. Participants in this trial will receive a PRP injection to assess its effectiveness in musculoskeletal conditions. ^{6 7 8 9 10}

Are You a Good Fit for This Trial?

This trial is for individuals with various musculoskeletal conditions such as different types of arthritis, tendinitis, and heel pain. Participants will be followed for one year after receiving a PRP injection to assess changes in pain, function, and satisfaction.

Inclusion Criteria

I have a muscle or joint condition that might improve with a PRP injection.

Other treatments I've tried did not work for me.

I am 18 years old or older.

Exclusion Criteria

I do not have any active cancer.

I do not have an infection where I will get the injection.

I do not have any ongoing infections.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a Platelet-Rich Plasma (PRP) injection and their whole blood and PRP are analyzed using a cell counter

1 day

1 visit (in-person)

Follow-up

Participants are monitored for changes in pain levels, functional abilities, and overall patient satisfaction through surveys at multiple time points

12 months

Surveys at 2 weeks, 6 weeks, 3 months, 6 months, and 12 months

What Are the Treatments Tested in This Trial?

Interventions

• Platelet Rich Plasma Injection

Trial Overview The study tests the effectiveness of Platelet Rich Plasma (PRP) injections on improving symptoms in patients with musculoskeletal conditions. It aims to create a patient registry and track outcomes over a year.

How Is the Trial Designed?

Group I: Platelet Rich Plasma Injection Experimental Treatment 2 Interventions

Participants who are eligible and provide consent to participate will undergo a Platelet-Rich Plasma (PRP) injection. Their whole blood and the produced PRP will be analyzed using a cell counter, and they will be asked to complete follow-up surveys at 2 weeks, 6 weeks, 3 months, 6 months, and 12 months..

Who Is Running the Clinical Trial?

University of Utah

Lead Sponsor

Trials

1,169

Recruited

1,623,000+

Citations

1. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC9747876/

Update on the Use of Platelet-Rich Plasma Injections in ... Two studies investigated PRP injections for chronic plantar fasciitis, and both reported positive results in pain and function with PRP. Finally ...

2. clinicaltrials.gov clinicaltrials.gov/study/NCT07231471?term=TREATMENt

Platelet Rich Plasma for Musculoskeletal Conditions This study will evaluate pain, function, and overall patient satisfaction outcomes for the use of PRP for the treatment of a diverse MSK ...

3. academic.oup.com academic.oup.com/painmedicine/article/26/7/407/8071874

Platelet-rich plasma injections as a second-line treatment in ... PRP significantly reduced pain at both 6 and 12 months compared to control treatments (mean difference: −0.83 [95% confidence intervals (CI): −1.61 to −0.04] at ...

4. sciencedirect.com sciencedirect.com/science/article/pii/S2773157X23001595

Therapeutic uses of platelet-rich plasma (PRP) in sport ... PRP has shown promising results in treating conditions such as patellar tendonitis, Achilles tendonitis, tennis elbow, partial rotator cuff tears, ligament ...

5. osiftl.com osiftl.com/peptide-injections-vs-platelet-rich-plasma-prp-therapy-for-musculoskeletal-injuries-a-review-of-the-evidence/

Peptide Injections vs. Platelet-Rich Plasma Therapy A landmark RCT found that PRP injections resulted in significant pain relief and functional improvements compared to corticosteroids at 6-month ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC10652151/

Current Status and Advancements in Platelet-Rich Plasma ... PRP is a promising conservative treatment modality for a variety of conditions with healing and regenerative capabilities and clear evidence of safety.

7. hopkinsmedicine.org hopkinsmedicine.org/health/treatment-tests-and-therapies/plateletrich-plasma-prp-treatment

Platelet-Rich Plasma (PRP) Injections PRP treatment can help support wound healing in trauma and joint injury. · The results of PRP treatment are most noticeable after several weeks for joint ...

8. clinicaltrials.gov clinicaltrials.gov/study/NCT07231471?lastUpdPost=2020-01-16_

Platelet Rich Plasma for Musculoskeletal Conditions This study will evaluate pain, function, and overall patient satisfaction outcomes for the use of PRP for the treatment of a diverse MSK ...

9. sciencedirect.com sciencedirect.com/science/article/pii/S2352320424001329

Adverse events related to platelet-rich plasma therapy and ... PRP therapy may involve several AEs, including postoperative infections, blindness, inflammation, allergic reactions, and nodule development.

10. bmcmusculoskeletdisord.biomedcentral.com bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-024-07629-1

The clinical efficacy and safety of platelet-rich plasma on ... The results showed that PRP was more durable and safer than corticosteroids and other control groups in the treatment of frozen shoulder.