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Emergency Response System Improvements for Cardiac Arrest

N/A
Waitlist Available
Led By Christopher Granger, MD
Research Sponsored by Duke University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Patients who have a pulse on arrival of EMS, where a successful defibrillation was previously administered by a bystander or first responder
OHCA of non-traumatic etiology
Timeline
Screening 3 weeks
Treatment Varies
Follow Up follow-up, up to 4 years
Awards & highlights

Study Summary

This trial is designed to improve outcomes for people who have a cardiac arrest outside of a hospital. It will enroll 50 counties in North Carolina, which are estimated to have a total of approximately 20,000 patients with cardiac arrest over a 4-year intervention period. The trial duration is 7 years.

Who is the study for?
The RACE-CARS trial is for patients who experience non-traumatic out-of-hospital cardiac arrest (OHCA) and are pulseless when first responders arrive or become pulseless in their presence. It's not for cases where resuscitation isn't attempted due to severe injuries, signs of death, decomposition, or a valid DNR order.Check my eligibility
What is being tested?
This study tests a system-wide intervention in 50 North Carolina counties to improve cardiac arrest outcomes. It includes rapid EMS dispatch, optimized first responder actions like early AED use, community CPR/AED training, and systematic bystander instruction by 911 operators.See study design
What are the potential side effects?
Since this trial focuses on emergency response systems rather than medications, there aren't traditional side effects. However, participants may experience varying levels of physical stress from CPR or defibrillation if they're resuscitated during the trial.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I was revived by a defibrillator before EMS arrived.
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My cardiac arrest was not caused by an injury.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~follow-up, up to 4 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and follow-up, up to 4 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Survival with good neurologic outcomes as measured by a CPC score of 1 or 2 at discharge
Secondary outcome measures
Percent of patients who receive CPR from a bystander as measured by EMS report
Rate of Defibrillation before paramedics arrive as measured by bystander interview
Other outcome measures
Change in Neurologic disability as measured by Modified Rankin Score
Change in Quality of life as measured by the EQ-5D-5L
Change in Quality of life as measured by the SF-36
+3 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Intervention (Enhanced Standard of Care)Experimental Treatment4 Interventions
Mass community CPR/AED training, optimize 911 medical dispatch, improve first responder performance
Group II: Control (Standard of Care)Active Control1 Intervention
Usual care, continuing standard quality improvement effort

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,814 Previous Clinical Trials
47,270,875 Total Patients Enrolled
13 Trials studying Cardiac Arrest
10,020 Patients Enrolled for Cardiac Arrest
Duke UniversityLead Sponsor
2,351 Previous Clinical Trials
3,389,546 Total Patients Enrolled
3 Trials studying Cardiac Arrest
1,721 Patients Enrolled for Cardiac Arrest
Christopher Granger, MDPrincipal InvestigatorDuke University
2 Previous Clinical Trials
1,203 Total Patients Enrolled

Media Library

Comprehensive community training of lay people in CPR and AED use. Clinical Trial Eligibility Overview. Trial Name: NCT04660526 — N/A
Cardiac Arrest Research Study Groups: Intervention (Enhanced Standard of Care), Control (Standard of Care)
Cardiac Arrest Clinical Trial 2023: Comprehensive community training of lay people in CPR and AED use. Highlights & Side Effects. Trial Name: NCT04660526 — N/A
Comprehensive community training of lay people in CPR and AED use. 2023 Treatment Timeline for Medical Study. Trial Name: NCT04660526 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are people with the specified condition still welcome to enroll in this research project?

"Unfortunately, this particular clinical trial is no longer looking for volunteers, as indicated by the most recent update on clinicaltrials.gov. Although this study is no longer enrolling, there are 267 other trials currently underway that are still recruiting patients."

Answered by AI
~12881 spots leftby Jun 2027