RAPD Strategy for Substance Abuse

(RAPD Trial)

Overseen By Christine R Koffkey, MPH

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: Wayne State University

Disqualifiers: Meet state standards, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

12 Participants Needed

Trial Summary

What is the purpose of this trial?

Using a 2-group, mixed method cluster randomized trial design, this study will compare standard implementation versus RAPD implementation strategy in Michigan Middle Schools

Will I have to stop taking my current medications?

The trial information does not specify whether participants need to stop taking their current medications.

What data supports the effectiveness of the RAPD treatment for substance abuse?

Research on adaptive interventions, which adjust treatment based on individual needs, shows promise in improving outcomes for adolescents with substance use disorders and in drug court settings. These interventions have been associated with higher success rates and faster resolution times, suggesting that similar strategies like RAPD could be effective for substance abuse treatment. ^{1 2 3 4 5}

How is the RAPD treatment for substance abuse different from other treatments?

The RAPD treatment is unique because it focuses on rapid adaptation to prevent drug use, potentially offering a more personalized approach compared to standard treatments. This method may involve adjusting the treatment based on an individual's specific needs, which is different from one-size-fits-all approaches. ^{1 2 6 7 8}

Research Team

Andria B Eisman, PhD, MPH, MS

Principal Investigator

Wayne State University

Eligibility Criteria

This trial is for Michigan middle schools with 7th-grade classes that have at least 25% of students eligible for free/reduced meals and are struggling to meet state standards for health curriculum implementation.

Inclusion Criteria

Schools that fail to meet state standards for implementation (less than 80% of curriculum) and/or face one or more barriers to Michigan Model for Health (MMH) curriculum implementation

My school has at least 25% of students on free or reduced meals.

Schools must include 7th-grade classes/students

Exclusion Criteria

Schools that meet state identified fidelity standards (i.e., teaching 80% or more of the curriculum) and do not face barriers to MMH implementation

Schools that have fewer than 25% of students eligible for free and reduced meals

Schools that do not include 7th-grade education level

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Implementation

Standard implementation versus RAPD implementation strategy is compared in Michigan Middle Schools

9 months

Follow-up

Participants are monitored for the acceptability, appropriateness, and feasibility of the RAPD strategy

4 weeks

Treatment Details

Interventions

• Rapid Adaptation to Prevent Drug Use (RAPD)
• Standard Implementation

Trial Overview The study compares two strategies: the usual way schools implement drug prevention programs versus a new, rapid adaptation method. Schools will be randomly assigned to one of these groups in equal numbers.

Participant Groups

Group I: Rapid Adaptation to Prevent Drug Use (RAPD) Experimental Treatment 1 Intervention

RAPD is a novel bundle of implementation strategies to improve the responsiveness of an existing evidence-based intervention (EBI), the Michigan Model for Health (MMH) for urgent drug events. These implementation strategies will be deployed in addition to standard implementation components.

Group II: Standard Michigan Model for Health (MMH) Curriculum Implementation Active Control 1 Intervention

Standard implementation of the MMH (Michigan Model for Health), a universal prevention intervention includes curriculum materials, foundational curriculum training and as-needed technical assistance, provided by the regional school health coordinators.

Who Is Running the Clinical Trial?

Wayne State University

Lead Sponsor

Trials

318

Recruited

111,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials

2,658

Recruited

3,409,000+

Findings from Research

The Smart Prescription Management (SPM) intervention significantly reduced opioid prescriptions from an average of 18 to 1.8 per patient, leading to a 30-90% improvement in managing doctor shopping and reducing overdose events and mortality.

The Smart Consumption Monitoring (SCM) intervention improved opioid adherence and decreased the likelihood of addiction by 10-30%, highlighting the effectiveness of adaptive interventions in preventing opioid use disorder.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Adaptive interventions for opioid prescription management and consumption monitoring. Singh, N., Varshney, U.[2023]

In a pilot study involving 30 participants in a misdemeanor drug court, those receiving an adaptive intervention had higher graduation rates and resolved their cases nearly 4 months faster than those in the standard program.

Participants in the adaptive intervention reported similar levels of satisfaction and therapeutic alliance with their counselors, indicating that the intervention is both effective and well-received.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Adaptive interventions may optimize outcomes in drug courts: a pilot study. Marlowe, DB., Festinger, DS., Arabia, PL., et al.[2021]

References

1. England pubmed.ncbi.nlm.nih.gov

Developing adaptive interventions for adolescent substance use treatment settings: protocol of an observational, mixed-methods project. [2019]

2. England pubmed.ncbi.nlm.nih.gov

Adolescents with cannabis use disorders: Adaptive treatment for poor responders. [2022]

3. England pubmed.ncbi.nlm.nih.gov

Adaptive interventions for opioid prescription management and consumption monitoring. [2023]

4. Ireland pubmed.ncbi.nlm.nih.gov

Identifying optimal level-of-care placement decisions for adolescent substance use treatment. [2023]

5. United States pubmed.ncbi.nlm.nih.gov

Adaptive interventions may optimize outcomes in drug courts: a pilot study. [2021]

6. England pubmed.ncbi.nlm.nih.gov

Measurement of negative consequences of substance use in street youth: an expanded use of the Rutgers Alcohol Problem Index. [2015]

7. United States pubmed.ncbi.nlm.nih.gov

The Rutgers Alcohol Problem Index for Adolescent Alcohol and Drug Problems: A Comprehensive Modern Psychometric Study. [2019]

8. United States pubmed.ncbi.nlm.nih.gov

Screening, Brief Intervention, and Referral to Treatment. [2017]