RAPD Strategy for Substance Abuse

(RAPD Trial)

Overseen By Christine R Koffkey, MPH

Age: Any Age

Sex: Any

Trial Phase: Academic

Sponsor: Wayne State University

Disqualifiers: Meet state standards, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

12 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to identify the most effective way to teach a health curriculum that prevents drug use in Michigan middle schools. Researchers will compare the standard teaching method with a new approach, Rapid Adaptation to Prevent Drug Use (RAPD), to determine which is more effective for schools facing challenges. Schools that struggle to implement at least 80% of the health curriculum or have other barriers, and where at least 25% of students qualify for free or reduced meals, may be suitable for this trial. As an unphased trial, this study offers the chance to contribute to innovative educational methods that could significantly impact student health and well-being.

Will I have to stop taking my current medications?

The trial information does not specify whether participants need to stop taking their current medications.

What prior data suggests that the RAPD implementation strategy is safe for middle school students?

Research has shown that the Rapid Adaptation to Prevent Drug Use (RAPD) strategy aims to improve current methods for preventing drug use. It introduces new ways to make these methods more effective in addressing emerging drug-related issues. RAPD is not a new drug or medication; instead, it enhances how schools manage drug problems.

Specific safety studies for RAPD do not exist because it focuses on implementation strategies rather than being a treatment with physical effects. However, it builds on the well-known Michigan Model for Health (MMH), which is already widely used in schools. This foundation suggests that RAPD is likely safe, as it extends an existing and accepted program. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the RAPD Strategy for Substance Abuse because it introduces a new approach to preventing drug use by enhancing the existing Michigan Model for Health (MMH). Unlike traditional methods that use standard curriculum implementation, RAPD rapidly adapts these interventions to address urgent drug events more effectively. This approach aims to make prevention efforts more responsive and timely, potentially offering quicker and more relevant support to those at risk. By adding these adaptive strategies to the established MMH curriculum, the goal is to improve the success rate of drug prevention in dynamic, real-world situations.

What evidence suggests that this trial's treatments could be effective for preventing drug use?

Research shows that the Rapid Adaptation to Prevent Drug Use (RAPD) strategy, which participants in this trial may receive, might reduce the impact of new drugs on young people. Previous studies have found that RAPD can quickly adjust to urgent drug situations, potentially decreasing drug-related harm, including serious health issues and deaths. This method builds on existing programs like the Michigan Model for Health (MMH) but adds flexible strategies to better address new drug threats. The standard implementation of the MMH curriculum, another arm of this trial, serves as a comparator to evaluate RAPD's effectiveness. While researchers continue to test RAPD, early results suggest it could positively impact schools, especially those serving low-income students. This could lead to safer environments and healthier choices for young people. ^{1 3 4 5 6}

Who Is on the Research Team?

Andria B Eisman, PhD, MPH, MS

Principal Investigator

Wayne State University

Are You a Good Fit for This Trial?

This trial is for Michigan middle schools with 7th-grade classes that have at least 25% of students eligible for free/reduced meals and are struggling to meet state standards for health curriculum implementation.

Inclusion Criteria

Schools that fail to meet state standards for implementation (less than 80% of curriculum) and/or face one or more barriers to Michigan Model for Health (MMH) curriculum implementation

Schools must include 7th-grade classes/students

My school has at least 25% of students on free or reduced meals.

Exclusion Criteria

Schools that meet state identified fidelity standards (i.e., teaching 80% or more of the curriculum) and do not face barriers to MMH implementation

Schools that have fewer than 25% of students eligible for free and reduced meals

Schools that do not include 7th-grade education level

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Implementation

Standard implementation versus RAPD implementation strategy is compared in Michigan Middle Schools

9 months

Follow-up

Participants are monitored for the acceptability, appropriateness, and feasibility of the RAPD strategy

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

• Rapid Adaptation to Prevent Drug Use (RAPD)
• Standard Implementation

Trial Overview The study compares two strategies: the usual way schools implement drug prevention programs versus a new, rapid adaptation method. Schools will be randomly assigned to one of these groups in equal numbers.

How Is the Trial Designed?

Group I: Rapid Adaptation to Prevent Drug Use (RAPD) Experimental Treatment 1 Intervention

RAPD is a novel bundle of implementation strategies to improve the responsiveness of an existing evidence-based intervention (EBI), the Michigan Model for Health (MMH) for urgent drug events. These implementation strategies will be deployed in addition to standard implementation components.

Group II: Standard Michigan Model for Health (MMH) Curriculum Implementation Active Control 1 Intervention

Standard implementation of the MMH (Michigan Model for Health), a universal prevention intervention includes curriculum materials, foundational curriculum training and as-needed technical assistance, provided by the regional school health coordinators.

Who Is Running the Clinical Trial?

Wayne State University

Lead Sponsor

Trials

318

Recruited

111,000+

National Institute on Drug Abuse (NIDA)

Collaborator

Trials

2,658

Recruited

3,409,000+

Published Research Related to This Trial

The Smart Prescription Management (SPM) intervention significantly reduced opioid prescriptions from an average of 18 to 1.8 per patient, leading to a 30-90% improvement in managing doctor shopping and reducing overdose events and mortality.

The Smart Consumption Monitoring (SCM) intervention improved opioid adherence and decreased the likelihood of addiction by 10-30%, highlighting the effectiveness of adaptive interventions in preventing opioid use disorder.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Adaptive interventions for opioid prescription management and consumption monitoring. Singh, N., Varshney, U.[2023]

In a pilot study involving 30 participants in a misdemeanor drug court, those receiving an adaptive intervention had higher graduation rates and resolved their cases nearly 4 months faster than those in the standard program.

Participants in the adaptive intervention reported similar levels of satisfaction and therapeutic alliance with their counselors, indicating that the intervention is both effective and well-received.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Adaptive interventions may optimize outcomes in drug courts: a pilot study. Marlowe, DB., Festinger, DS., Arabia, PL., et al.[2021]

Citations

1. reporter.nih.gov reporter.nih.gov/project-details/10887425

The Rapid Adaption to Prevent Drug Use (RAPD ... We will design a RAPD to optimize responses to urgent drug use events and pilot test in schools serving low-income students to assess equity. We will assess ...

2. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11748840/

Rapid Adaptation to Prevent Drug Use (RAPD) This study focuses on designing and deploying implementation strategies to reduce the detrimental impact of emerging drugs.

3. link.springer.com link.springer.com/content/pdf/10.1186/s40814-024-01581-6.pdf

Rapid Adaptation to Prevent Drug Use (RAPD) This line of research has the potential to reduce the notable consequences of emerging drugs, including preventable morbidity and mortality among youth. Widely ...

4. researchgate.net researchgate.net/publication/388233143_Rapid_Adaptation_to_Prevent_Drug_Use_RAPD_protocol_of_a_pilot_randomized_trial_to_enhance_the_impact_of_an_evidence-based_intervention_for_youth

(PDF) Rapid Adaptation to Prevent Drug Use (RAPD) This study focuses on designing and deploying implementation strategies to reduce the detrimental impact of emerging drugs.

5. issup.net issup.net/knowledge-share/resources/2025-01/rapid-adaptation-prevent-drug-use-rapd-protocol-pilot-randomized

Rapid Adaptation to Prevent Drug Use (RAPD) This study aims to create strategies that can quickly reduce the impact of emerging drugs among youth. By reviewing past responses using AAR, we ...

6. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/39838453/

Rapid Adaptation to Prevent Drug Use (RAPD) RAPD refers to a novel set of implementation strategies designed to enhance the capacity of an existing, widely adopted evidence-based universal ...