Exercise + Radiation Therapy for Prostate Cancer
Trial Summary
What is the purpose of this trial?
This study is being done to determine if patients receiving personalized exercise therapy (versus those who do not receive personalized exercise therapy) have improved quality of life and physical functioning after completing their radiation therapy. Second, the study is being done to find if the quality of life changes during therapy correlate with measurements of inflammation in the blood. Third, the study is being done to see if adding exercise therapy to radiation therapy will improve survival.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications. However, it allows for prior or current use of hormone therapy and chemotherapy agents, so you may not need to stop these treatments.
What data supports the effectiveness of the treatment Exercise + Radiation Therapy for Prostate Cancer?
Is exercise combined with radiation therapy for prostate cancer safe?
Radiation therapy for prostate cancer, including external beam radiation and brachytherapy, has been studied for safety. Common side effects include issues with the urinary and digestive systems, but these are generally not severe. Exercise therapy is generally safe and can improve overall health, though specific safety data for its combination with radiation therapy is limited.678910
How does the Exercise + Radiation Therapy treatment for prostate cancer differ from other treatments?
This treatment is unique because it combines radiation therapy with exercise to help reduce fatigue and improve quality of life in prostate cancer patients. Exercise during radiation therapy has been shown to lessen treatment-related side effects, such as fatigue and rectal toxicity, making it a novel approach compared to standard radiation therapy alone.1112131415
Research Team
Nicholas Zaorsky, MD
Principal Investigator
University Hospitals Cleveland Medical Center, Case Comprehensive Cancer Center
Eligibility Criteria
This trial is for men over 18 with metastatic prostate cancer undergoing their first round of palliative radiation therapy. They must have had hormone therapy, be in a stable condition (ECOG ≤3), and speak English. Exclusions include severe heart conditions, respiratory failure, high fracture risk, heavy current exercisers (>90 min/week), or those treated outside the specified hospitals.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Radiation Therapy
Participants receive standard of care radiation treatment, with or without exercise therapy
Exercise Therapy
Participants in the experimental group receive personalized exercise therapy alongside radiation treatment
Follow-up
Participants are monitored for safety and effectiveness after treatment, including weekly follow-up calls for 4 weeks
Treatment Details
Interventions
- Exercise therapy
- Radiation therapy
Radiation therapy is already approved in European Union, United States, Canada, Japan, China, Switzerland for the following indications:
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Cervical cancer
- Uterine cancer
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Esophageal cancer
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
- Nasopharyngeal cancer
- Breast cancer
- Lung cancer
- Colorectal cancer
- Prostate cancer
- Brain tumors
- Skin cancer
Find a Clinic Near You
Who Is Running the Clinical Trial?
Milton S. Hershey Medical Center
Lead Sponsor
Case Comprehensive Cancer Center
Lead Sponsor