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Genetic Testing

Mosaic Embryo Transfer for Infertility

N/A

Recruiting

Led By Mandy Katz-Jaffe, PhD

Research Sponsored by Colorado Center for Reproductive Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Women age 18-45

Women age 18-45 Infertile women who have completed an IVF cycle with PGT at the Colorado Center for Reproductive Medicine (CCRM) that have a mosaic embryo

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 12-15 months after birth of baby

Awards & highlights

Study Summary

This trial looks at whether it's safe to transfer a mosaic embryo that's been screened for genetic abnormalities.

Who is the study for?

This trial is for women aged 18-45 who are infertile and have completed an IVF cycle with PGT at CCRM, possessing a mosaic embryo. They must be willing to transfer only one embryo and meet the clinic's standards for an embryo transfer. It excludes those desiring multiple embryos, using gestational carriers, or having certain chromosomal errors.Check my eligibility

What is being tested?

The study investigates the outcomes of transferring a single mosaic embryo (with both normal and abnormal cells) after preimplantation genetic testing in infertile women. The focus is on understanding the success rate and potential risks associated with such transfers.See study design

What are the potential side effects?

As this trial involves the transfer of a mosaic embryo during IVF, side effects may include typical IVF-related discomforts like cramping or bloating; however, specific risks related to carrying a mosaic embryo will be closely monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am a woman aged between 18 and 45.

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I am a woman aged 18-45, infertile, completed IVF with PGT at CCRM, and have a mosaic embryo.

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I am willing to have a single embryo transferred.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 12-15 months after birth of baby

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~12-15 months after birth of baby

This trial's timeline: 3 weeks for screening, Varies for treatment, and 12-15 months after birth of baby for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Evaluation of Implantation rate

Live birth rate

Secondary outcome measures

Miscarriage Rates

Neonatal Outcomes

Pregnancy complications

+3 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Transfer of mosaic embryoExperimental Treatment1 Intervention

Women will have a mosaic embryo transferred to their uterus after in vitro fertilization (IVF) with pre implantation genetic testing completed at Colorado Center for Reproductive Medicine.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Colorado Center for Reproductive MedicineLead Sponsor

5 Previous Clinical Trials

400 Total Patients Enrolled

4 Trials studying Infertility

346 Patients Enrolled for Infertility

Mandy Katz-Jaffe, PhDPrincipal Investigator - Fertility Genetics

Colorado Center for Reproductive Medicine

2 Previous Clinical Trials

279 Total Patients Enrolled

2 Trials studying Infertility

279 Patients Enrolled for Infertility

Media Library

Mosaic Embryo Transfer (Genetic Testing) Clinical Trial Eligibility Overview. Trial Name: NCT04472156 — N/A

Infertility Research Study Groups: Transfer of mosaic embryo

Infertility Clinical Trial 2023: Mosaic Embryo Transfer Highlights & Side Effects. Trial Name: NCT04472156 — N/A

Mosaic Embryo Transfer (Genetic Testing) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04472156 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this clinical research recruiting participants currently?

"Per the information which is hosted on clinicaltrials.gov, this trial has opened applications for participants. It was first posted in October 2020 and last edited in July 2022."

Answered by AI

What is the scope of participation in this clinical experiment?

"Correct. A review of clinicaltrials.gov reveals that this trial, which was launched on October 15th 2020, is actively searching for participants. Up to 250 patients are expected to join from a single medical centre."

Answered by AI

Who meets the criteria to be a participant in this experiment?

"A total of 250 people between the ages 18 to 45 will be admitted in this clinical trial. To qualify, applicants must have already been through a IVF cycle with PGT at CCRM and possess a mosaic embryo; moreover, they should not be restricted by race, culture, sexual orientation or ethnicity while being willing to transfer single embryos."

Answered by AI

What is the ultimate aim of this investigation?

"The chief outcome of this study, assessed over a 9-12 month post embryo transfer period, is the Implantation rate. Additionally, Stillbirth rates related to Mosaic Embryo Transfer will be examined as well as Prenatal testing results and Products of conception from miscarriage."

Answered by AI