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Chemotherapy + Radiation for Kidney Cancer (Wilms' Tumor)
Study Summary
This trial is studying how well combo chemo with or without radiation therapy works to treat young patients newly diagnosed with stage III or stage IV Favorable Histology Wilms' tumor.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I can perform most of my daily activities without assistance.You must have a negative pregnancy test.I am not currently taking aprepitant.Your liver enzymes (AST or ALT) are not more than 2.5 times the normal level.I haven't had chemotherapy or radiotherapy, except as part of COG-AREN0532 or for urgent medical reasons.I have been recently diagnosed with Wilms' tumor at a specific stage.Your bilirubin levels are within a certain range.I will start treatment within 2 weeks after my surgery or biopsy, unless my doctor advises against it.Your heart's pumping function is normal, as shown by specific heart tests.
- Group 1: Treatment (chemotherapy, surgery, radiotherapy)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What are some of the primary conditions that cyclophosphamide is used to treat?
"While most commonly used as a treatment for lung cancer, cyclophosphamide can also be taken to help manage small cell lung cancer (sclc), multiple sclerosis, leukemia, myelocytic and acute conditions."
Are there many research facilities conducting this trial throughout America?
"There are 100 different clinical trial sites currently enrolling patients for this study. While Columbus, Dallas and New york have participating locations, there are also many other places that you can choose from to minimize the amount of travel required."
What are the predecessors of this experiment?
"Alfacell conducted the first study on cyclophosphamide in 1997 and, after a Phase 3 drug approval, there are currently 1189 active trials for this medication across 74 countries and 2555 cities."
Are there any unfilled appointments in this clinical trial?
"The latest update on clinicaltrials.gov reveals that this trial is not currently looking for patients to enroll. That being said, there are still 3657 other trials recruiting individuals for medical studies."
How many people are taking part in this clinical trial?
"This particular clinical trial is no longer recruiting patients. First posted on February 26th, 2007 and last updated on March 23rd, 20212, the study has finished admitting participants. However, there are 2468 other trials actively recruiting stage iv wilms tumor patients and 1189 cyclophosphamide trials currently underway."
What are the most similar previous studies to this one involving cyclophosphamide?
"There are 1189 clinical trials currently underway that involve the use of cyclophosphamide. Out of these, 252 have reached Phase 3. Additionally, there are 43519 locations worldwide where these trials are taking place."
Are there any notable risks associated with cyclophosphamide?
"Cyclophosphamide's safety is well-documented, as this drug has completed Phase 3 clinical trials."
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