Perturbation Training for Stroke Survivors

YW
SD
Overseen ByShamali Dusane, MPT
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to help stroke survivors improve balance and reduce fall risk through a program called overground slip perturbation training. The program strengthens both the weaker and stronger sides of the body to make walking safer and more stable. Stroke survivors who had a stroke more than six months ago, have some mobility, and no recent major surgeries might be a good fit for this trial. The trial will test if this training can reduce falls and improve walking in real-life settings, not just in the lab. Wearable sensors will monitor participants to track improvements in everyday settings. As an unphased trial, this study offers a unique opportunity to contribute to innovative research that could enhance daily life for stroke survivors.

Do I need to stop my current medications for the trial?

The trial information does not specify if you need to stop taking your current medications. However, it mentions that participants should not be on any sedative drugs.

What prior data suggests that this training protocol is safe for stroke survivors?

Research shows that slip perturbation training is generally well-tolerated by stroke survivors. This training effectively reduces the risk of falls and improves balance. In one study, participants noticed better balance control after just one session, indicating its safety for stroke recovery. Another study found that this training helps lower the risk of falls in people with long-term stroke effects. While some research suggests that more evidence is needed, major negative effects have not been commonly reported. This suggests that slip perturbation training is a promising and safe way to help stroke survivors manage fall risks.12345

Why are researchers excited about this trial?

Researchers are excited about slip perturbation training for stroke survivors because it offers a novel approach to rehabilitation. Unlike traditional therapies that may focus mainly on strength and balance exercises, this method involves exposing patients to controlled slips while they walk. This technique is thought to help retrain the brain and improve balance responses, potentially reducing the risk of falls. By simulating real-life scenarios where slips might occur, it actively engages the nervous system in a way that traditional exercises don't, making it a promising addition to stroke recovery strategies.

What evidence suggests that this trial's slip perturbation training could be effective for stroke survivors?

Research has shown that overground slip perturbation training can reduce the risk of falling for people who have had a stroke. In this trial, researchers will divide participants into different groups. Some will receive slip perturbation training, either for sub-acute or chronic stroke, while others will be in control groups. Studies have found that patients experienced fewer falls and improved stability after slipping. These benefits were noticeable from the first training session and lasted for several months. For those living with the effects of a stroke for a long time, the training maintained these improvements for up to a year. While the strongest evidence supports those with long-term stroke effects, early results suggest that people who recently had a stroke might also benefit. This training focuses on strengthening both sides of the body, helping stroke survivors improve their balance and ability to walk.12367

Who Is on the Research Team?

TB

Tanvi Bhatt, PhD PT

Principal Investigator

University of Illinois at Chicago

Are You a Good Fit for This Trial?

This trial is for stroke survivors who can walk at least 10 meters with or without help, have had a stroke over 6 months ago confirmed by their doctor and brain scans. They should not have other major health issues, recent surgeries, hospital stays, or be on sedatives.

Inclusion Criteria

I haven't had major surgery or been hospitalized recently and am not on sedatives.
I can walk (with or without help) and have had a stroke over 6 months ago, causing lasting weakness on one side.
I can walk at least 10 meters, with or without help like a cane or brace.

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Monitoring

Baseline activity monitoring using wearable sensors for chronic stroke subjects

4 weeks

Treatment

Slip perturbation training for stroke survivors, targeting both paretic and non-paretic limbs

6 weeks

Follow-up

Participants are monitored for stability and fall incidence post-training

12 months

What Are the Treatments Tested in This Trial?

Interventions

  • Overground slip perturbation training
Trial Overview The study tests a new training method to prevent falls in people who've had strokes. It involves slip-perturbation training that focuses on improving balance and walking function by first training the non-affected limb then the affected one.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Active Control
Group I: Slip training for sub-acute strokeExperimental Treatment1 Intervention
Group II: Slip training for chronic strokeExperimental Treatment1 Intervention
Group III: Control for sub-acute strokeActive Control1 Intervention
Group IV: Control for chronic strokeActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials
653
Recruited
1,574,000+

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Collaborator

Trials
2,103
Recruited
2,760,000+

Citations

1.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/37780126/
Motor adaptation and immediate retention to overground ...Abstract. Background: Perturbation-based training has shown to be effective in reducing fall-risk in people with chronic stroke (PwCS).
Motor adaptation and immediate retention to overground ...Perturbation-based training has shown to be effective in reducing fall-risk in people with chronic stroke (PwCS). However, most evidence comes from ...
Perturbation Training for Fall-risk Reduction Among Stroke ...The purpose of this research is to understand the effect of bilateral slip-perturbation training protocol targeting training both paretic vs. non-paretic limbs ...
Motor adaptation and immediate retention to overground ...Background: Perturbation-based training has shown to be effective in reducing fall-risk in people with chronic stroke (PwCS).
Long-term retention effects of overground walk-slip training ...The training group demonstrated improvements from baseline to 6 months (p < 0.02), with no differences between the 6- and 12-month sessions (except improvements ...
A systematic review of perturbation-based balance training ...It is the first review of perturbation training's effect to reduce falls in stroke. · Current evidence of perturbation reducing falls in stroke is insufficient.
Assessment of Postural Control and Gait in Patients with ...The BBS scores showed that both treadmill perturbation-based training performed six days a week for three weeks (the EG) and overground gait and ...
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