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Transcranial Magnetic Stimulation

TMS for Stroke Rehabilitation

N/A

Waitlist Available

Led By Julianne Freeman, BS

Research Sponsored by Emory University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

No history of seizures or epilepsy

Single ischemic infarction affecting the primary motor system

Timeline

Screening 3 weeks

Treatment Varies

Follow Up before, 0 mins after, 30 mins after and 60 mins after motor training.

Awards & highlights

Study Summary

This trial will test if a type of brain stimulation can help improve motor skills.

Who is the study for?

This trial is for stroke survivors aged 30-80, with a single ischemic infarction impacting the motor system. Participants must be able to consent, have no cognitive impairments or depression, and not suffer from other neurological diseases. They can't have contraindications to TMS like epilepsy, metal in the head/neck, implanted devices, history of migraines or take seizure-lowering meds.Check my eligibility

What is being tested?

The study tests if repetitive transcranial magnetic stimulation (rTMS) on different parts of the brain improves motor function after a stroke. It involves various rTMS techniques over specific brain areas and sham treatments for comparison.See study design

What are the potential side effects?

Possible side effects include discomfort at the stimulation site, headache, lightheadedness, twitching facial muscles during treatment sessions and in rare cases seizures may occur.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have never had seizures or epilepsy.

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I had a stroke that affected my movement control.

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My thinking and memory skills are functioning well.

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I do not have any neurological diseases.

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I have never had a migraine headache.

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I am between 30 and 80 years old.

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I am not taking any medication that increases my risk of seizures.

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I am not currently experiencing depression.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ before, 0 mins after, 30 mins after and 60 mins after motor training.

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~before, 0 mins after, 30 mins after and 60 mins after motor training.

This trial's timeline: 3 weeks for screening, Varies for treatment, and before, 0 mins after, 30 mins after and 60 mins after motor training. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Change in Stimulus Response Curve parameters

Change in wrist velocity

Secondary outcome measures

Change in Resting Motor Threshold

Change in Short interval intracortical inhibition (SICI) of the primary motor cortex

Change in reaction time

+2 more

Trial Design

5Treatment groups

Experimental Treatment

Placebo Group

Group I: Single TMS over extensor carpi ulnaris spot of motor cortexExperimental Treatment1 Intervention

Location of single-pulse Transcranial Magnetic Stimulation (sTMS): extensor carpi ulnaris (ECU) hotspot of primary motor cortex (M1).

Group II: Repetitive TMS over ipsilateral premotor cortexExperimental Treatment1 Intervention

Location of repetitive Transcranial Magnetic Stimulation (rTMS): ipsilateral premotor cortex.

Group III: Repetitive TMS over contralateral primary motor cortexExperimental Treatment1 Intervention

Location of repetitive Transcranial Magnetic Stimulation (rTMS): contralateral primary motor cortex.

Group IV: Repetitive TMS over contralateral premotor cortexExperimental Treatment1 Intervention

Location of repetitive Transcranial Magnetic Stimulation (rTMS): contralateral premotor cortex.

Group V: Sham repetitive TMS over contralateral premotor cortexPlacebo Group1 Intervention

Location of Sham repetitive Transcranial Magnetic Stimulation (rTMS): contralateral premotor cortex.

0 / 8Eligibility criteria met

Find a Location

Who is running the clinical trial?

Emory UniversityLead Sponsor

1,636 Previous Clinical Trials

2,560,503 Total Patients Enrolled

28 Trials studying Stroke

347,942 Patients Enrolled for Stroke

American Heart AssociationOTHER

324 Previous Clinical Trials

4,933,708 Total Patients Enrolled

39 Trials studying Stroke

3,925,003 Patients Enrolled for Stroke

Julianne Freeman, BSPrincipal InvestigatorEmory University

Media Library

Repetitive TMS over contralateral premotor cortex (Transcranial Magnetic Stimulation) Clinical Trial Eligibility Overview. Trial Name: NCT03268070 — N/A

Stroke Research Study Groups: Sham repetitive TMS over contralateral premotor cortex, Single TMS over extensor carpi ulnaris spot of motor cortex, Repetitive TMS over contralateral premotor cortex, Repetitive TMS over ipsilateral premotor cortex, Repetitive TMS over contralateral primary motor cortex

Stroke Clinical Trial 2023: Repetitive TMS over contralateral premotor cortex Highlights & Side Effects. Trial Name: NCT03268070 — N/A

Repetitive TMS over contralateral premotor cortex (Transcranial Magnetic Stimulation) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03268070 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there an opportunity for me to join this experiment?

"This clinical trial requires 70 individuals between the age of 30 and 80, who have experienced a stroke. Eligible candidates must possess written consent capabilities, be free from depression or neurological conditions, have no contraindications to transcranial magnetic stimulation (TMS), lack any history of epilepsy or seizures, not contain implants in their body nor metals near their head/neck area; furthermore they need to demonstrate intact cognitive abilities as well as singular ischemic infarction that affects key motor systems."

Answered by AI

Are any patients currently being accepted for this trial?

"Based on the information posted to clinicaltrials.gov, it is evident that this trial has ceased patient recruitment as of October 3rd 2022. However, there are 1043 other studies with open enrollment opportunities available currently."

Answered by AI

Are those younger than 50 years of age admissible to this experiment?

"This medical experiment seeks participants aged between 30 and 80 years old."

Answered by AI

What ultimate goal is the clinical trial attempting to accomplish?

"The primary evaluation metric for this trial is the alteration of wrist velocity over a period before, 0 minutes after, 30 minutes after and 60 minutes after motor training. Furthermore, secondary objectives include assessing alterations in wrist force via 7 isometric extensions; Short Interval Intracortical Inhibition (SICI) within the primary motor cortex through sub-threshold conditioning stimulus and supra-threshold test stimuli; as well as changes in Resting Motor Threshold through Parametric Estimation by Sequential Testing (PEST)."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Transcranial Magnetic Stimulation in Stroke Motor Rehabilitation Treatment

Cathrin Buetefisch 2024. "Transcranial Magnetic Stimulation in Stroke Motor Rehabilitation Treatment". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03268070.

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