TMS for Stroke Rehabilitation
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how repetitive transcranial magnetic stimulation (rTMS) can improve movement and brain function in individuals who have experienced a stroke affecting their motor skills. Participants will receive various types of rTMS to determine which method best enhances recovery and brain adaptability. This trial suits those who have had a single stroke impacting their primary motor system, have no other neurological diseases, and are not currently experiencing depression. As an unphased trial, it offers participants the chance to contribute to pioneering research that could enhance stroke recovery methods.
Do I need to stop my current medications for the trial?
The trial does not specify if you need to stop taking your current medications, but you cannot take any medication that lowers the seizure threshold.
Is there any evidence suggesting that this trial's treatments are likely to be safe?
Research shows that repetitive transcranial magnetic stimulation (rTMS) is generally safe and well-tolerated. Studies have found that both high and low-frequency rTMS do not cause serious side effects. People who have undergone this treatment often find it easy to handle.
This study focuses on specific brain areas: the opposite side of the premotor cortex, the opposite side of the primary motor cortex, and the same side of the premotor cortex. Research indicates that targeting these areas with rTMS can improve motor function without causing significant problems.
In past studies, participants usually experienced only mild side effects, if any. These might include a slight headache or discomfort where the stimulation is applied, but these effects are usually temporary. Overall, evidence suggests that rTMS is a safe option for those considering joining a clinical trial.12345Why are researchers excited about this trial's treatments?
Researchers are excited about these TMS treatments for stroke rehabilitation because they offer a non-invasive approach to improving motor function. Unlike traditional rehabilitation methods that rely on physical therapy, these treatments use repetitive Transcranial Magnetic Stimulation (rTMS) to directly stimulate brain areas involved in movement. This technique targets specific brain regions, such as the contralateral and ipsilateral premotor cortex and the primary motor cortex, potentially enhancing neuroplasticity and speeding up recovery. The ability to precisely focus on different brain areas might offer more personalized and effective rehabilitation options compared to conventional therapies.
What evidence suggests that this trial's treatments could be effective for stroke rehabilitation?
Research has shown that repetitive transcranial magnetic stimulation (rTMS) can help stroke patients improve movement abilities. In this trial, participants will receive different types of rTMS. Some will have rTMS applied to the contralateral premotor cortex, which studies have found significantly enhances motor skills, especially in the arms. Others will receive rTMS over the contralateral primary motor cortex, improving hand function and reducing movement problems. Additionally, some participants will have rTMS applied to the ipsilateral premotor cortex, as evidence suggests this might aid recovery by reducing brain inhibition and boosting activity. Overall, rTMS shows promise for aiding stroke rehabilitation and improving movement.12467
Who Is on the Research Team?
Cathrin Buetefisch, MD
Principal Investigator
Emory University
Are You a Good Fit for This Trial?
This trial is for stroke survivors aged 30-80, with a single ischemic infarction impacting the motor system. Participants must be able to consent, have no cognitive impairments or depression, and not suffer from other neurological diseases. They can't have contraindications to TMS like epilepsy, metal in the head/neck, implanted devices, history of migraines or take seizure-lowering meds.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex to improve motor performance
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Repetitive TMS over contralateral premotor cortex
- Repetitive TMS over contralateral primary motor cortex
- Repetitive TMS over ipsilateral premotor cortex
- Sham Repetitive TMS over contralateral premotor cortex
- Single TMS over extensor carpi ulnaris spot of motor cortex
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
American Heart Association
Collaborator