TMS for Stroke Rehabilitation
CB
Overseen ByCathrin Buetefisch, MD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Emory University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Trial Summary
What is the purpose of this trial?
The goal of the study is to determine the effect of repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex on training-related improvements in motor performance and associated neural plasticity.
Research Team
CB
Cathrin Buetefisch, MD
Principal Investigator
Emory University
Eligibility Criteria
This trial is for stroke survivors aged 30-80, with a single ischemic infarction impacting the motor system. Participants must be able to consent, have no cognitive impairments or depression, and not suffer from other neurological diseases. They can't have contraindications to TMS like epilepsy, metal in the head/neck, implanted devices, history of migraines or take seizure-lowering meds.Inclusion Criteria
You do not have any reasons that would make transcranial magnetic stimulation (TMS) unsafe for you.
I have never had seizures or epilepsy.
Ability to give informed, written consent
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Exclusion Criteria
Not applicable.
Timeline
Screening
Participants are screened for eligibility to participate in the trial
2-4 weeks
Treatment
Participants receive repetitive transcranial magnetic stimulation (rTMS) over the premotor cortex to improve motor performance
6 weeks
Weekly sessions
Follow-up
Participants are monitored for safety and effectiveness after treatment
4 weeks
Treatment Details
Interventions
- Repetitive TMS over contralateral premotor cortex
- Repetitive TMS over contralateral primary motor cortex
- Repetitive TMS over ipsilateral premotor cortex
- Sham Repetitive TMS over contralateral premotor cortex
- Single TMS over extensor carpi ulnaris spot of motor cortex
Trial Overview The study tests if repetitive transcranial magnetic stimulation (rTMS) on different parts of the brain improves motor function after a stroke. It involves various rTMS techniques over specific brain areas and sham treatments for comparison.
Participant Groups
5Treatment groups
Experimental Treatment
Placebo Group
Group I: Single TMS over extensor carpi ulnaris spot of motor cortexExperimental Treatment1 Intervention
Location of single-pulse Transcranial Magnetic Stimulation (sTMS): extensor carpi ulnaris (ECU) hotspot of primary motor cortex (M1).
Group II: Repetitive TMS over ipsilateral premotor cortexExperimental Treatment1 Intervention
Location of repetitive Transcranial Magnetic Stimulation (rTMS): ipsilateral premotor cortex.
Group III: Repetitive TMS over contralateral primary motor cortexExperimental Treatment1 Intervention
Location of repetitive Transcranial Magnetic Stimulation (rTMS): contralateral primary motor cortex.
Group IV: Repetitive TMS over contralateral premotor cortexExperimental Treatment1 Intervention
Location of repetitive Transcranial Magnetic Stimulation (rTMS): contralateral premotor cortex.
Group V: Sham repetitive TMS over contralateral premotor cortexPlacebo Group1 Intervention
Location of Sham repetitive Transcranial Magnetic Stimulation (rTMS): contralateral premotor cortex.
Find a Clinic Near You
Who Is Running the Clinical Trial?
Emory University
Lead Sponsor
Trials
1,735
Recruited
2,605,000+
American Heart Association
Collaborator
Trials
352
Recruited
6,196,000+
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