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Alcohol's Impact on Decision-Making in PTSD (PACS Trial)

N/A

Recruiting

Led By Josh Cisler, PhD

Research Sponsored by University of Texas at Austin

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be between 18 and 65 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year

Awards & highlights

PACS Trial Summary

This trial will investigate how PTSD increases risk for AUDs, and how alcohol may alter decision-making in PTSD, to inform interventions & prevention efforts.

Who is the study for?

This trial is for adults aged 21-60 with PTSD who have had at least two occasions in the past year where they consumed a significant amount of alcohol (4 drinks for men, 3 for women). They must be diagnosed with PTSD through an interview.Check my eligibility

What is being tested?

The study examines how acute alcohol consumption affects decision-making related to approach-avoidance conflict in individuals with PTSD. It involves controlled administration of alcohol and placebo, along with neuroimaging and computational analysis.See study design

What are the potential side effects?

Possible side effects include typical reactions to alcohol such as impaired judgment, dizziness, nausea, or more severe responses if participants have unusual sensitivity to alcohol.

PACS Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Relations between changes in dorsal anterior cingulate cortex activation with alcohol use over a one-year follow-up

Relations between ratio of approach to avoidance choices with alcohol use over a one-year follow-up

changes in dorsal anterior cingulate cortex activation

+1 more

PACS Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: AlcoholActive Control1 Intervention

Participants will drink beverages containing alcohol.

Group II: PlaceboPlacebo Group1 Intervention

Participants will drink beverages containing a very low dose of alcohol (placebo condition).

Do I qualify?Apply below to find out

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Who is running the clinical trial?

University of Texas at AustinLead Sponsor

353 Previous Clinical Trials

81,044 Total Patients Enrolled

Josh Cisler, PhDPrincipal InvestigatorUniversity of Texas at Austin

1 Previous Clinical Trials

35 Total Patients Enrolled

Elizabeth Lippard, PhDPrincipal InvestigatorUniversity of Texas at Austin

3 Previous Clinical Trials

260 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this research offer access to participants above the age of thirty?

"This study is seeking out individuals who are between 21 and 60 years old."

Answered by AI

To whom does this research initiative extend its invitation?

"Applicants for this medical trial must be diagnosed with post-traumatic stress disorder and aged between 21 and 60. This study aims to enrol 200 individuals in total."

Answered by AI

Are there opportunities for participation in this clinical trial at present?

"Clinicaltrials.gov confirms that this study, considered on September 1st 2023 and last amended on August 15th 2023, is not at present recruiting applicants. Nevertheless, there are 665 other trials looking for patient enrolment as of now."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Approach-Avoidance and Alcohol Challenge Study in PTSD

Elizabeth Thomas Cox Lippard 2023. "Approach-Avoidance and Alcohol Challenge Study in PTSD". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06002633.

All > Ptsd Austin