Carbon Monoxide Measurement for Liver Regeneration
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how measuring carbon monoxide levels in the breath can aid in understanding liver regeneration after surgery. Researchers aim to determine if a link exists between carbon monoxide production and the liver's healing and function after partial removal. They collect breath samples from participants to monitor these levels. Individuals undergoing partial liver removal due to liver disease or cancer may be suitable for this study.
As an unphased trial, this study provides a unique opportunity to contribute to groundbreaking research that could enhance liver surgery outcomes.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications.
What prior data suggests that this method is safe for monitoring liver regeneration?
Research suggests that carbon monoxide (CO) might aid liver healing after surgery by accelerating recovery. Although specific safety data for CO use in this trial is unavailable, CO treatments have been studied in other contexts. For example, inhaled CO has undergone safety testing in kidney treatments. Researchers prioritize liver safety when developing new drugs. While specific data for this trial is lacking, existing research indicates that CO is generally safe in similar medical situations.12345
Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a novel method for supporting liver regeneration by measuring carbon monoxide levels in the breath. Unlike traditional methods that might rely on imaging or blood tests to assess liver health, this approach offers a non-invasive and potentially quicker way to monitor liver regeneration. By detecting carbon monoxide, which can be a byproduct of liver activity, this technique could provide real-time insights into how well the liver is recovering, paving the way for more personalized and timely interventions.
What evidence suggests that carbon monoxide measurement is effective for liver regeneration?
Research shows that carbon monoxide (CO) can affect liver health. Studies have found that CO helps the liver heal and regrow after partial removal. In patients with liver transplants, lower CO levels have been linked to better monitoring of liver function. Additionally, CO has been used to prevent damage when blood flow returns to the liver after surgery, improving survival rates. This trial will involve all participants providing breath samples to detect carbon monoxide levels, which could enhance understanding and support of liver recovery.12356
Who Is on the Research Team?
Cherif Boutros, MD
Principal Investigator
Englewood Hospital
Are You a Good Fit for This Trial?
This trial is for individuals undergoing partial hepatectomy, a surgical procedure to remove part of the liver. It's aimed at those who may have conditions like liver cancer or hepatocellular carcinoma and are interested in monitoring their liver regeneration post-surgery.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Pre-surgery Assessment
Participants provide baseline breath samples to measure carbon monoxide levels
Post-surgery Monitoring
Participants provide breath samples at 4 and 24 hours post-resection to measure carbon monoxide levels
Follow-up
Participants undergo CT liver volumetric studies and blood tests to assess liver regeneration and function
What Are the Treatments Tested in This Trial?
Interventions
- Carbon Monoxide Measurement
Find a Clinic Near You
Who Is Running the Clinical Trial?
Englewood Hospital and Medical Center
Lead Sponsor