Your session is about to expire
← Back to Search
Decitabine for COVID-19 (DART Trial)
DART Trial Summary
This trial is testing if the leukemia drug decitabine can help people with severe COVID-19. 40 people will be enrolled, half receiving decitabine and half receiving a placebo. The primary objective is to determine if decitabine is safe and effective for COVID-19 ARDS.
DART Trial Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowDART Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.DART Trial Design
Find a Location
Who is running the clinical trial?
Media Library
- My liver enzymes or bilirubin levels are very high, or my kidneys are not working well.I am not currently taking any immune system modifying drugs or specific medications like Palifermin, Dipyrone, or Deferiprone.I am currently receiving or have recently received chemotherapy for my solid tumor cancer.I use a machine to help with my breathing.I am not taking any nonbiologic immunosuppressants like JAK or BTK inhibitors.My lung function is severely impaired, as shown by a specific oxygen test.You are currently taking or participating in a trial for another experimental treatment for SARS-CoV-2.I have tested positive for COVID-19 through a lab test.Your blood counts show low levels of certain types of blood cells: white blood cells, red blood cells, or platelets.I do not have active HIV or any uncontrolled infections.I am 18 years old or older.You have had a bad reaction to decitabine in the past.
- Group 1: Decitabine + Standard of Care (SOC)
- Group 2: Standard of Care (SOC) + Placebo
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What malady is Decitabine + Standard of Care (SOC) typically employed to ameliorate?
"Decitabine + Standard of Care (SOC) is typically administered to individuals with intermediate-2 risk according to the International Prognostic Scoring System. It can also be employed for ipss high risk, refractory anemias, and anemia management."
Are any enrollees currently being accepted into this research endeavor?
"This trial has ceased to accept new patients, as the most recent update was made on November 22nd 2022. If you are in search of other studies, there are 1,159 currently recruiting for Covid-19 and 102 accepting enrolment into Decitabine + Standard of Care (SOC) trials."
Has the combination of Decitabine and Standard of Care (SOC) been endorsed by the Food & Drug Administration?
"Our team determined a score of 2 for the safety of Decitabine + Standard of Care (SOC) due to its Phase 2 trial status. This means that there is some evidence supporting the medication's security, but none evaluating its effectiveness."
What are the desired outcomes of this medical experiment?
"The primary analysis of this trial, measured over a 28-day period from randomization, will assess the change in clinical state via an ordinal assessment scale. Secondary metrics to be examined include Ventilator Free Days (VFD), Time to Polymerase Chain Reaction Negativity (PCR NEG), and Change in Oxygenation Index (OI)."
What is the aggregate tally of participants enrolled in this clinical study?
"Unfortunately, this trial is not currently accepting candidates. The study was initially posted on September 14th 2020 and the last update occurred on November 22nd 2022. If you are hunting for other medical trials, 1159 covid-19 studies and 102 Decitabine + Standard of Care (SOC) experiments are presently enrolling participants."
Has Decitabine been previously evaluated in conjunction with SOC for therapeutic purposes?
"Currently, 102 clinical trials exploring Decitabine + Standard of Care (SOC) are underway worldwide. Of those studies, 15 have entered the third phase of research and Philadelphia is hosting the highest number thereof. However, there are 1,483 locations operating such trials in total."
Share this study with friends
Copy Link
Messenger