Peanut Protein for Metabolism

Age: 65+

Sex: Any

Trial Phase: Academic

Sponsor: Texas A&M University

Must not be taking: Corticosteroids, Protein supplements

Disqualifiers: Diabetes, Heart disease, Kidney disease, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

Duration: 4 study days

15 Participants Needed

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications. However, if you are using long-term oral corticosteroids or have used a short course of oral corticosteroids within 4 weeks before the study, you may not be eligible to participate.

What data supports the effectiveness of the treatment Peanut protein for metabolism?

Research shows that providing protein as part of nutritional support can improve outcomes in patients with protein deficits, especially in those with gastrointestinal issues. This suggests that peanut protein, as a source of dietary protein, might help improve protein metabolism and overall health in similar contexts. ^{1 2 3 4 5}

Is peanut protein generally safe for humans?

Research shows that peanut protein can cause allergic reactions, especially in people with peanut allergies. However, a study on mice fed with peanut sprout powder showed no toxic effects, suggesting it might be safe in certain forms. Always consult with a healthcare provider before participating in a trial involving peanut protein. ^{6 7 8 9 10}

How does peanut protein treatment differ from other treatments for metabolism?

Peanut protein treatment is unique because it utilizes the natural protein content of peanuts, which is comparable to animal protein in digestibility, to potentially enhance metabolism. Unlike other treatments, it may also offer additional nutritional benefits, such as improved amino acid profiles and antioxidant properties, through processes like fermentation. ^{11 12 13 14 15}

What is the purpose of this trial?

Peanuts are considered a functional food and regular consumption is associated with positive health effects. Protein is the second most common nutrient in peanuts after fat. The protein digestibility of peanuts is similar to that of animal protein, and the limiting amino acids in peanuts vary based on the study and are suggested to be lysine, methionine, or threonine. Defining the reduced responsiveness of various dietary proteins to induce anabolism in older adults is critical for preventing and attenuating physical and cognitive health decline.

Research Team

Marielle Engelen, Ph.D.

Principal Investigator

Texas A&M University

Eligibility Criteria

This trial is for adults interested in the health effects of peanut protein on metabolism. Specific eligibility criteria are not provided, so it's best to contact the study organizers for details on who can participate.

Inclusion Criteria

I am willing and able to follow the study's requirements.

Previous completion of IRB2023-0549: Prandial Metabolic Phenotyping in Sarcopenic Older Adults Comparing Plant Based and Whey Based Protein (NCT06628349)

I am willing to lie flat on my back for up to 6 hours.

Exclusion Criteria

I have never been treated for liver or kidney disorders.

I am currently being treated for a chronic condition like diabetes, cancer, heart, kidney, liver disease, HIV/AIDS, severe asthma, or hepatitis.

Use of protein or amino acids containing nutritional supplements within 5 days of the first study day

Timeline

Screening

Participants are screened for eligibility to participate in the trial

1 day

1 visit (in-person, approx. 3 hours)

Treatment

Participants receive liquid nutritional supplements containing 45g of peanut protein as sip feeds every 20 minutes for 5 hours

4 study days

4 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

2 weeks

Treatment Details

Interventions

• Peanut protein

Trial Overview The trial is exploring how peanut protein affects protein metabolism. It aims to understand if peanuts can be a good source of dietary protein and help maintain physical and cognitive health, especially in older adults.

Participant Groups

Group I: Healthy male older adults Experimental Treatment 1 Intervention

Group II: Healthy female older adults Experimental Treatment 1 Intervention

Who Is Running the Clinical Trial?

Texas A&M University

Lead Sponsor

Trials

156

Recruited

28,900+

References

1. England pubmed.ncbi.nlm.nih.gov

Nutritional modulation of protein metabolism after gastrointestinal surgery. [2013]

2. England pubmed.ncbi.nlm.nih.gov

Comparison of the effect of three different protein content enteral diets on serum levels of proteins, nitrogen balance, and energy expenditure in critically ill infants: study protocol for a randomized controlled trial. [2020]

3. United States pubmed.ncbi.nlm.nih.gov

Performance responses and indicators of gastrointestinal health in early-weaned pigs fed low-protein amino acid-supplemented diets. [2022]

4. Switzerland pubmed.ncbi.nlm.nih.gov

Protein intake in renal and hepatic disease. [2011]

5. Canada pubmed.ncbi.nlm.nih.gov

Impact of nutrition support on patient outcome and hospital costs. [2004]

6. Germany pubmed.ncbi.nlm.nih.gov

Purification and characterisation of a panel of peanut allergens suitable for use in allergy diagnosis. [2021]

7. United States pubmed.ncbi.nlm.nih.gov

An evaluation of the sensitivity of subjects with peanut allergy to very low doses of peanut protein: a randomized, double-blind, placebo-controlled food challenge study. [2019]

8. United States pubmed.ncbi.nlm.nih.gov

Airborne concentrations of peanut protein. [2019]

9. India pubmed.ncbi.nlm.nih.gov

Allergenicity reduction of the bio-elicited peanut sprout powder (BPSP) and toxicological acceptance of BPSP-supplemented diets assessed with ICR mice. [2022]

10. England pubmed.ncbi.nlm.nih.gov

Allergy to peanut oil--clinically relevant? [2017]

11. France pubmed.ncbi.nlm.nih.gov

Proteolysis of the peanut allergen Ara h 1 by an endogenous aspartic protease. [2020]

12. Netherlands pubmed.ncbi.nlm.nih.gov

Peanut as a source of protein for human foods. [2019]

13. United States pubmed.ncbi.nlm.nih.gov

Enhancement of Nutritional and Antioxidant Properties of Peanut Meal by Bio-modification with Bacillus licheniformis. [2017]

14. United States pubmed.ncbi.nlm.nih.gov

Isolation and characterization of a peanut maturity-associated protein. [2019]

15. England pubmed.ncbi.nlm.nih.gov

Purification and identification of antioxidant peptides from peanut protein isolate hydrolysates using UHR-Q-TOF mass spectrometer. [2018]