Prostate cancer often presents with no symptoms at all. Symptoms usually appear after the cancer has started to spread to nearby pelvic lymph nodes. Most prostate cancers do not cause any pain during urination. Signs and symptoms can vary depending on the stage of the disease and how far it has spread. The primary signs include increased difficulty passing urine, backache, unexplained bleeding, a lump in the pelvis, painful sex, loss of sexual desire, a change in the shape of the penis or body, or problems with bladder control. Other less common ways that prostate cancer can present are urinary frequency, feeling incomplete emptying of the bladder, swollen lymph nodes around the groin area, loss of appetite, and bone pains.
Prostate cancer is relatively uncommon among men under 50 years old. However, it kills more men than breast cancer or colon cancer combined. The survival rate after treatment is 10 percent less than that of women with breast cancer, but only 2 percent worse than that of men with colon cancer. It is therefore important to diagnose and treat prostate cancer as soon as possible.
Men whose relatives were diagnosed with prostate cancer have approximately 50% increased odds of having prostate cancer themselves. This effect appears to operate through both genetic linkage and shared environmental effects. The percentage of men who develop prostate cancer does not appear to differ significantly among men who are more than five years younger at diagnosis of prostate cancer than it does among men ages 40 to 65 years older.
MRI has provided all the information needed for definitive diagnosis of [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer). Improvements are awaited in terms of detection of tumour extent in the peripheral regions of the prostate.
MRI offers several advantages over CT scans and ultrasound when looking at the prostate. It can provide more information on the status of the prostate than other imaging techniques can. MRI also has fewer artifacts than CT images. Therefore, MRI is a superior method for pelvic imaging.
The causes of prostate cancer are multifactorial, including genetic, environmental, behavioural and hormonal factors. The most likely combination of these factors are thought to be responsible for the development of prostate cancer. The causative roles of cigarette smoking and alcohol consumption remain unclear.
The findings suggest that metastases occur within 12 weeks after diagnosis of invasive PCa. However, distant metastases are relatively rare in patients with early stage disease, and their occurrence is associated with shorter survival. Early detection of metastases should therefore be encouraged.
Overall, the average age at diagnosis was 68 years old for all [prostate cancer](https://www.withpower.com/clinical-trials/prostate-cancer)s. But for localized cancers, it was 51 years older (P<0.001). Median age at diagnosis was 66 years for advanced prostate cancer. And mean age at diagnosis was 65 years for localized disease (P<0.001), 67 years for locally recurrent/metastatic (P<0.001) prostate cancer, and 79 years for metastatic prostate cancer (P<0.001).
MR is frequently used as a diagnostic tool for determining the extent of pelvic and para-aortic lymphadenopathy in patients presenting with advanced prostate cancer. The addition of MRI to traditional staging techniques resulted in no change in treatment decisions in more than half of our patients. The value of MRI in the evaluation of patients with organ-confined disease remains unclear and warrants further investigation.
MRI was often used as part of treatment planning but was not typically combined with other forms of therapy. Further study into the use of MRI during treatment is warranted.
Recent findings do not support the existence of any familial pattern of prostate cancer among our study population. It is important to note that this information does not exclude the possibility that the genetic basis for prostate cancer might exist but has yet to be discovered.