Time Restricted Eating for Weight Management

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Illinois at Chicago

Must not be taking: Weight loss, Glucose-lowering

Disqualifiers: Diabetes, Eating disorders, Pregnancy, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

90 Participants Needed

Trial Summary

What is the purpose of this trial?

A 12-month randomized, controlled, parallel-arm trial, divided into 2 consecutive periods: (1) 6-month weight loss period; and (2) 6-month weight maintenance, will be implemented. Adults with obesity will be randomized to 1 of 3 groups: (1) 8h-TRE, ad libitum food intake from 12pm to 8 pm, fasting from 8 pm to 12 pm daily, (2) CR, 25% energy restriction every day; or 3) control, ad libitum food intake daily, eating within more than 10 hours per day.

Research Team

Krista Varady, PhD

Principal Investigator

University of Illinois Chicago

Eligibility Criteria

This trial is for adults aged 18-70 with obesity (BMI of 30-50) who are sedentary or lightly active. It's not suitable for those unstable in weight, on certain medications, unable to maintain a food/activity log, with eating disorders, irregular menstrual cycles, smokers, diabetics, night shift workers, or pregnant individuals.

Inclusion Criteria

I am mostly inactive or lightly active.

You haven't been doing much physical activity in the past 3 months, like walking or light exercise, for less than an hour per week.

I am between 18 and 70 years old.

Exclusion Criteria

Your weight has changed by more than 4 kilograms in the past 3 months.

I am not on medications that affect weight or blood sugar.

Pregnant, or trying to become pregnant

Treatment Details

Interventions

• 8-hour Time restricted eating
• Calorie restriction

Trial Overview The study tests if eating within an 8-hour window (12pm-8pm) leads to better weight management compared to daily calorie restriction or no intervention over a year. Participants will first focus on losing weight for six months and then maintaining it for another six.

Participant Groups

Group I: Calorie restriction Experimental Treatment 1 Intervention

25% energy restriction every day

Group II: 8-hour Time restricted eating Experimental Treatment 1 Intervention

Ad libitum food intake from 12-8 pm every day Fasting from 8-12 pm every day (16-h fast)

Group III: Control Active Control 1 Intervention

Usual diet, Ad libitum intake, eating within \>10 hours per day

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials

653

Recruited

1,574,000+