Protein Powders for Nutrition

GD
Overseen ByGwen Duytschaever
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to understand how the body processes different protein powders. Participants will consume two types of protein products: a fast-digesting milk protein (milk protein concentrate) and a slow-digesting micellar casein (micellar casein isolate). Researchers will measure the absorption rate of amino acids (the building blocks of proteins) in the small intestine and its impact on digestion. Ideal candidates for this study are healthy individuals who can maintain their usual diet and activity levels, have no major gastrointestinal issues, and are not on regular prescription medications. As an unphased study, this trial allows participants to contribute to foundational research on protein digestion.

Will I have to stop taking my current medications?

The trial requires that you do not use regular prescription medications that could affect the study's safety or outcome. If you are taking medications that alter gastrointestinal function, you may need to stop them a week before the study, except for laxatives and proton pump inhibitors, which have specific guidelines. Please consult with the study team for more details.

Is there any evidence suggesting that this trial's treatments are likely to be safe?

Research has shown that Micellar Casein Isolate (MCI) is often used in food products and is generally well-tolerated. This protein is commonly found in sports nutrition items like shakes and bars. Reports of harmful side effects are rare when used as directed for nutrition.

Milk Protein Concentrate (MPC) is also popular in protein powders and shakes. However, a small concern exists. Some studies have found that protein powders can sometimes contain high levels of heavy metals like lead. This doesn't mean every product has this issue, but it's something to consider when choosing protein supplements.

Both proteins are used regularly by many people without major safety concerns. However, staying informed and choosing products carefully is always advisable. Before joining a trial, consider discussing these points with the study team.12345

Why are researchers excited about this trial?

Researchers are excited about Micellar Casein Isolate (MCI) and Milk Protein Concentrate (MPC) because they offer unique nutritional benefits compared to standard protein supplements like whey or soy proteins. Unlike other treatments that primarily focus on rapid digestion, MCI is known for its slow digestion, which provides a prolonged release of amino acids and may enhance muscle protein synthesis over time. On the other hand, MPC combines casein and whey, potentially offering both fast and slow-release proteins in one product. This combination could provide a balanced approach to muscle recovery and growth, appealing to those seeking optimal nutrition post-exercise.

What evidence suggests that this trial's treatments could be effective for nutrition?

This trial will compare the effects of Micellar Casein Isolate (MCI) and Milk Protein Concentrate (MPC) on muscle health and physical performance. Research has shown that MCI can improve muscle endurance and reduce tiredness during workouts by slowing protein breakdown, aiding muscle recovery and growth over time. MPC, on the other hand, has been linked to increased muscle strength and lean body mass, especially when combined with strength training. It also boosts appetite and improves certain health markers, benefiting overall well-being. Both proteins provide essential building blocks for muscle repair and growth. Participants in this trial will receive both MCI and MPC in different intervention periods to assess their effectiveness in promoting muscle health and enhancing physical performance.678910

Are You a Good Fit for This Trial?

This trial is for healthy individuals interested in how their bodies digest different protein powders. Participants will try two types of proteins: a fast-digesting milk concentrate and a slow-digesting casein isolate. Specific eligibility details are not provided, but typically participants should have no major health issues.

Inclusion Criteria

Signed Informed Consent; willing & able to comply with study procedures
Willing to maintain their diet and physical activity levels during the study
I can swallow a large capsule.
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Exclusion Criteria

Consumption of probiotic or prebiotic supplements within 1 month prior to screening
Colon cleanses/bowel prep for 2 weeks
Pregnant or breastfeeding
See 17 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Intervention Phase 1

Participants ingest the MCI/SP protein product for their first intervention period

4 weeks
Weekly visits for sample collection and monitoring

Intervention Phase 2

Participants ingest the MPC/FP protein product for their second intervention period

4 weeks
Weekly visits for sample collection and monitoring

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Micellar Casein Isolate
  • Milk Protein Concentrate
Trial Overview The study compares the digestion of two protein supplements: Milk Protein Concentrate (fast-acting) and Micellar Casein Isolate (slow-acting). Healthy volunteers will consume each product during separate phases to assess amino acid levels and gastric emptying rates.
How Is the Trial Designed?
2Treatment groups
Active Control
Group I: MCI/SP to MPC/FPActive Control2 Interventions
Group II: MPC/FP to MCI/SPActive Control2 Interventions

Find a Clinic Near You

Who Is Running the Clinical Trial?

Nimble Science Ltd.

Lead Sponsor

Trials
11
Recruited
570+

Citations

Effects of soluble milk protein or casein supplementation on ...The main results revealed enhanced muscle endurance (i.e., number of repetitions), reduced fatigue (i.e., muscle power loss) and slightly ...
Casein Protein Supplementation in Trained Men and WomenThe purpose of this investigation was to determine the effects of casein supplementation (54 grams) in the morning (Casein-MOR) or evening (Casein-EVE) (90 ...
Ingestion of whey hydrolysate, casein, or soy protein isolateConversely, casein has a modest effect on whole body protein synthesis but instead inhibits whole body protein breakdown (3, 8, 9). Thus, at least at the whole ...
Effects of soluble milk protein or casein supplementation on ...The main results revealed enhanced muscle endurance (i.e., number of repetitions), reduced fatigue (i.e., muscle power loss) and slightly ...
Comparison of milk protein concentrate, micellar casein, ...Improved stability, water solubility, increased encapsulation rate, extended shelf life, and bioavailability of lipophilic medicines during gastrointestinal ...
Micellar Casein Isolate (Kosher, Halal)Sports nutrition products; Biscuits and other baked goods. Documents. Technical Documents. Safety Data Sheet View / Download. Product Details. Grade. Food.
Casein Protein - Uses, Side Effects, and moreLearn more about Casein Protein uses, effectiveness, possible side effects, interactions, dosage, user ratings and products that contain Casein Protein.
Chocolate Micellar Casein Protein - 5 Pound Bulk, GMO ...Naked Chocolate Casein contains no artificial sweeteners or colors and is GMO-Free, No rBGH or rBST, Soy Free and Gluten-Free.
What's the Difference Between Casein and Whey Protein?Whey protein is a popular supplement with many health benefits, but some worry about its safety. Here's a review of whey protein's safety and ...
Reconstitution properties of micellar casein powderA problem associated with micellar casein (MC) powders is their poor reconstitution properties. In this study, we prepared MCs with different salt and ...
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