SPM™ for Healthy Skin
(SPMT Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores how a new skin product, SPM™, can improve skin appearance, enhance hydration, and protect the skin's barrier. Participants will apply the product to one area of their skin for six weeks, while another area remains untreated for comparison. Researchers will assess changes by measuring the skin's moisture levels and structure before and after product use. This trial suits healthy adults without ongoing skin issues who consent to small skin samples being taken. As an unphased trial, it offers participants the chance to contribute to foundational research that could lead to innovative skincare solutions.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are currently using systemic corticosteroids or immunosuppressants.
What prior data suggests that SPM™ is safe for cosmetic use?
Research has shown that SPM™, a cream made with peptides, is designed to be safe for cosmetic use. This treatment includes ingredients like amino acids, vitamins, and recombinant human serum albumin, which are commonly found in skincare products and are known to be well-tolerated.
Although detailed safety studies specifically on SPM™ are lacking, its ingredients are generally considered safe for skin application. In cosmetics, safety checks often avoid animal testing and use alternative methods to ensure products do not irritate the skin or cause other issues.
This study is exploratory and focuses on cosmetic use, so the treatment is not expected to cause significant side effects. Participants will apply the product only to their skin, reducing the risk of serious adverse effects.12345Why are researchers excited about this trial?
SPM™ is unique because it combines peptides, amino acids, vitamins, and recombinant human serum albumin to enhance skin health, hydration, and barrier function. Unlike most standard skincare treatments, which often focus on moisturizing or exfoliating, SPM™ aims to improve skin structure and function at a molecular level. Researchers are excited about this treatment because it leverages a new peptide-based formulation that could offer more comprehensive skin benefits than conventional topical products.
What evidence suggests that SPM™ is effective for improving skin appearance and hydration?
Research has shown that SPM™, a cream made with special proteins, might improve skin health by reducing irritation and boosting skin function. Early laboratory studies found that SPM™ can decrease certain proteins that cause skin irritation. The cream is also designed to increase skin moisture and strengthen the skin's protective layer, promoting skin health. In this trial, participants will apply SPM™ to one designated skin area, while another area will remain untreated as a control. Although human trial data is limited, these early results suggest that SPM™ could enhance skin health and hydration.15678
Are You a Good Fit for This Trial?
This trial is for healthy adults interested in improving their skin's appearance, hydration, and barrier function. Participants should be willing to apply a topical peptide-based formulation twice daily and undergo noninvasive skin measurements as well as small punch biopsies.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants apply SPM™ topical cosmetic formulation twice daily for six weeks to a designated skin area
Follow-up
Participants are monitored for safety and effectiveness after treatment, including a final safety follow-up visit to evaluate recovery and participant-reported outcomes
What Are the Treatments Tested in This Trial?
Interventions
- SPM™
Trial Overview
The study tests the effects of SPM™, a new skincare product, on healthy adult skin over six weeks. It measures how well it hydrates the skin and strengthens its barrier by comparing treated areas with untreated ones using tools like Tewameter® and Corneometer®.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Participants will apply the SPM™ topical cosmetic formulation twice daily for six (6) weeks to a designated skin area (e.g., right arm). SPM™ is a peptide-based cosmetic formulation containing amino acids, vitamins, and recombinant human serum albumin, designed to support healthy skin appearance, hydration, and barrier function. A matching contralateral site (e.g., left arm) will remain untreated and serve as the within-subject control for comparison. No product will be applied to this area. Skin biopsies (3-6 mm) will be obtained from both the treated and untreated sites at two timepoints: Baseline (before starting SPM™ application), and End of the 6-week product-use period. Biopsy samples from both sites will be analyzed in parallel to characterize cosmetic skin attributes (e.g., structure, hydration-related markers, and barrier-related characteristics) and to compare changes between the SPM™-treated and untreated control areas.
Find a Clinic Near You
Who Is Running the Clinical Trial?
BizCoz Global PTE. LTD
Lead Sponsor
Biocoz Global Pte. Ltd.
Lead Sponsor
Citations
Evaluation of SPM™ Topical Cosmetic Application on Skin ...
Preclinical data demonstrate reduced expression of inflammatory cytokines and potential improvements in epidermal physiology.
2.
trial.medpath.com
trial.medpath.com/clinical-trial/b57bd151c0126028/nct07236736-spm-topical-cosmetic-skin-hydration-barrierEvaluation of SPM™ Topical Cosmetic Application on Skin ...
Preclinical data demonstrate reduced expression of inflammatory cytokines and potential improvements in epidermal physiology.
3.
medicaldevicenavigator.com
medicaldevicenavigator.com/upcoming_clinical_study_evaluates_spm_cosmetic_application/Upcoming Clinical Study Evaluates SPM™ Cosmetic ...
The trial's main goals include quantifying the impact of SPM™ on skin hydration levels and overall barrier integrity. These parameters are critical in assessing ...
Fibroblast exosomes promote wound healing and improve the ...
Our findings demonstrate that fibroblast exosome treatment not only accelerates wound closure but also improves the long-term quality of healed ...
Biochemical insights into specialized plant metabolites
Clinical studies have demonstrated the efficacy of flavonoids in improving skin barrier function and reducing irritation. For instance, quercetin, a ...
6.
researchgate.net
researchgate.net/publication/49638924_Safety_of_botanical_ingredients_in_personal_care_productscosmeticsSafety of botanical ingredients in personal care products/ ...
When choosing new ingredients for cosmetic formulations, data on cyto-and genotoxicity, skin irritation, photosensitization, dermal ...
3 questions to master the microplastic regulation in cosmetics
Cosmetic manufacturers have to be vigilant about compliance. In this article, let's understand the regulation on microplastics and microbeads use, explore the ...
Safety assessment of cosmetics by read across applied to ...
As a result of the cosmetics testing ban, safety evaluations of cosmetics ingredients must now be conducted using animal-free methods.
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