Cardiac MRI for Heart Disease
(SPINS2 Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests whether detailed heart scans can diagnose heart disease more effectively than regular scans. It uses a vasodilator, a medication that widens blood vessels, to observe blood flow to the heart during stress, such as exercise. Individuals who frequently experience chest pain or shortness of breath and have been advised they might have heart disease could be suitable candidates. The trial includes two groups: one receiving detailed scans and the other receiving standard scans. As an unphased trial, this study provides a unique opportunity to advance heart disease diagnosis techniques.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that cardiac MRI is safe for diagnosing heart disease?
Research has shown that using a vasodilator, a medicine that widens blood vessels, during a heart MRI is safe. One study found stress cardiac MRI to be safe and effective in predicting major heart problems in patients with heart failure. Another review highlighted the benefits of assessing blood flow in the heart during these tests.
These findings suggest that the vasodilator used in this study is well-tolerated. No major safety issues emerged in these studies, indicating that this method is generally considered safe for participants in a clinical trial.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it explores a new way to evaluate myocardial blood flow using cardiac MRI. Unlike the standard qualitative approach, this new method combines both quantitative and qualitative stress cardiac magnetic resonance imaging, potentially offering more detailed insights into heart health. By providing a more comprehensive view of blood flow in the heart, this technique could improve the accuracy of diagnosing heart disease, leading to better treatment decisions.
What evidence suggests that this trial's methods could be effective for diagnosing heart disease?
Research has shown that using certain medications called vasodilators with heart MRI scans effectively assesses heart function. In this trial, participants will undergo either a new myocardial blood flow evaluation or a standard one. Studies indicate that stress MRI, which uses a vasodilator to simulate exercise, helps identify heart problems. This method predicts major heart events, such as heart attacks, in people with heart failure. It also safely measures the severity of heart disease by accurately assessing blood flow. Overall, this approach is reliable and adds value to heart health checks.13678
Are You a Good Fit for This Trial?
This trial is for individuals experiencing chest pain or shortness of breath, who may have heart problems like blocked coronary arteries. Participants should be suitable for cardiac MRI tests and willing to undergo stress testing that simulates exercise.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants have demographics and imaging characteristics recorded at baseline visits
Treatment
Participants receive standardized quantitative stress cardiac magnetic resonance imaging protocol with Gadavist and vasodilator stress
Follow-up
Participants are monitored for safety and effectiveness after treatment, with follow-up via email or telephone at 3, 12, and 24 months
What Are the Treatments Tested in This Trial?
Interventions
- Vasodilator
Find a Clinic Near You
Who Is Running the Clinical Trial?
Brigham and Women's Hospital
Lead Sponsor