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Understanding Cannabis Use and Depression in Young People with HIV

N/A
Recruiting
Led By Vilma Gabbay, MD
Research Sponsored by Albert Einstein College of Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 month
Awards & highlights

Study Summary

This trial will investigate the mechanisms of substance use disorders and comorbid mental illnesses in people living with HIV.

Who is the study for?
This trial is for young adults aged 18-34 living with HIV in The Bronx, who experience depression and frequently use cannabis but do not have major psychiatric conditions like bipolar or psychotic disorders. Participants must be fluent in English or Spanish, able to consent, and have an IQ over 75. They should not have MRI contraindications like claustrophobia or metallic implants nor severe medical illnesses.Check my eligibility
What is being tested?
The study aims to understand how cannabis use affects the brain's reward and pain responses in young adults with HIV. It involves MRI scans for all participants to observe neural activity related to substance abuse disorders and depression.See study design
What are the potential side effects?
Since this trial involves MRI scans, there are minimal side effects expected. However, some individuals might feel discomfort due to the confined space of the scanner (claustrophobia) or loud noises during scanning.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 month
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 month for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
neural circuitry underling reward and pain
Secondary outcome measures
AUDIT-C The higher the score the greater the alcohol use disorder.
Addiction Severity Index (ASI)
Beck Depression Inventory-II (BDI-II) Score 0-63 higher the score greater the depression
+16 more
Other outcome measures
3-item R-UCLA Loneliness Scale Range 3-9. Higher the lonelier a participant feels
Anxiety
Feeling suicidal (finding)
+8 more

Trial Design

1Treatment groups
Experimental Treatment
Group I: PLWHExperimental Treatment1 Intervention
All participants will undergo neuroimaging and behavioral tests.

Find a Location

Who is running the clinical trial?

National Institute on Drug Abuse (NIDA)NIH
2,470 Previous Clinical Trials
2,619,451 Total Patients Enrolled
38 Trials studying Depression
62,313 Patients Enrolled for Depression
Albert Einstein College of MedicineLead Sponsor
287 Previous Clinical Trials
11,856,828 Total Patients Enrolled
8 Trials studying Depression
1,554 Patients Enrolled for Depression
Vilma Gabbay, MDPrincipal InvestigatorAlbert Einstein College of Medicine
2 Previous Clinical Trials
640 Total Patients Enrolled

Media Library

PLWH Clinical Trial Eligibility Overview. Trial Name: NCT05453513 — N/A
Depression Research Study Groups: PLWH
Depression Clinical Trial 2023: PLWH Highlights & Side Effects. Trial Name: NCT05453513 — N/A
PLWH 2023 Treatment Timeline for Medical Study. Trial Name: NCT05453513 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is enrollment still available for this investigation?

"According to information accessible on clinicaltrials.gov, this medical trial is currently enrolling participants. The research was first posted in April 1st 2022 and the most recent update occurred August 18th of that same year."

Answered by AI

Does this clinical investigation include participants aged forty and over?

"The age range for participants to be eligible for this medical study is from 18 years old up to 34."

Answered by AI

What main aims is this research trying to achieve?

"The aims of this trial, measured within an initial time frame, are to assess the Brief Pain Inventory (BPI). Secondary data points include Time Flowback (TLFB) - a tool for quantifying marijuana, cigarette and other drug use; Daily sessions and Frequency as outlined by Age of Onset; Quantity of Cannabis Use Inventory (DFAQ-CU); CUPIT which measures risky or problematic cannabis consumption."

Answered by AI

Am I eligible to contribute to this research effort?

"This clinical trial seeks 280 people between the ages of 18-34 that are suffering from depression. To qualify, applicants must be HIV positive (confirmed via lab reports or testing), able to understand study procedures and sign informed consent forms (with an IQ higher than 75 on a full-scale basis), have used cannabis regularly in recent months but not necessarily meet DSM-5 criteria for Cannabis Use Disorder, and display at least moderate symptoms of depression as determined by a raw score ≥12 on the Montgomery Asberg Depression Rating Scale."

Answered by AI

Approximately how many participants are being observed in this research project?

"Affirmative. Information from clinicaltrials.gov states that this research study is currently recruiting participants, with the initial posting on April 1st 2022 and last edit occurring August 18th of the same year. 280 potential test subjects are needed at a single site for participation in the trial."

Answered by AI

Who else is applying?

What state do they live in?
New York
What site did they apply to?
Vilma Gabbay, MD, MS
What portion of applicants met pre-screening criteria?
Did not meet criteria
How many prior treatments have patients received?
3+
Recent research and studies
clinicaltrials.govStudy
The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV
Vilma Gabbay 2022. "The Neural Underpinnings of Depression and Cannabis Use in Young People Living With HIV". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05453513.
All > Depression New York
~143 spots leftby Jul 2026
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