PICO vs Standard Care Dressings for Preventing Surgical Site Infections
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but if you are on warfarin therapy, you cannot participate in the study.
What data supports the effectiveness of the treatment Aquacel Ag Surgical Dressing and PICO for preventing surgical site infections?
Research shows that the Aquacel Ag Surgical Dressing significantly reduces the rate of surgical site infections (SSIs) and improves patient satisfaction after surgeries like total knee arthroplasty. Additionally, the PICO system, a type of negative pressure wound therapy, has been effective in reducing wound complications, including infections, in various surgical and traumatic wounds.12345
Is the PICO dressing generally safe for use in humans?
The PICO dressing has been used safely in various studies for different types of wounds, including surgical and traumatic wounds, without significant safety concerns. It has been shown to reduce complications like infections and wound dehiscence (wound reopening) in some cases, although its effectiveness can vary depending on the specific condition and patient group.34567
How does the PICO treatment differ from standard care for preventing surgical site infections?
The PICO treatment is unique because it uses a single-use negative pressure wound therapy system, which helps to reduce wound complications by applying gentle suction to the wound area, promoting faster healing and reducing the risk of infection. This is different from standard care dressings, which do not use negative pressure and may require more frequent changes.34567
What is the purpose of this trial?
This trial is comparing two types of dressings for patients having repeat knee or hip replacement surgeries. One dressing uses suction to help wounds heal faster, while the other uses silver to prevent infections. The goal is to see which dressing better prevents healing problems. Topical silver agents and dressings are used to control infection and promote healing in chronic wounds, but reviews have found mixed results regarding their effectiveness.
Eligibility Criteria
This trial is for adults over 18 who need a second knee or hip surgery and can follow the study plan. They must not be pregnant, breastfeeding, or at risk of pregnancy without contraception. People with skin issues that prevent wound therapy use, active bleeding at the site, allergies to dressing materials, or on warfarin are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Single-Use NPWT (PICO) or standard care dressings (AQUACEL Ag Surgical Dressing) during revision TKA and THA
Follow-up
Participants are monitored for incision healing complications
Treatment Details
Interventions
- Aquacel Ag Surgical Dressing
- Revision Total Joint Arthroplasty
- Single-Use Negative Pressure Wound Therapy (PICO)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Rothman Institute Orthopaedics
Lead Sponsor