Physical Activity Coaching for Lung Cancer

Recruiting at 13 trial locations

Overseen By Dan Raz, MD

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: City of Hope Medical Center

Disqualifiers: Lung surgery in less than 14 days

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 5

382 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to determine if phone-based coaching can boost physical function for older adults undergoing lung cancer surgery. It compares this method to self-monitoring of physical activity. The coaching includes setting personal fitness goals and participating in phone sessions both before and after surgery. This trial may suit individuals aged 65 or older who are scheduled for lung cancer surgery and can speak English or Spanish. As an unphased trial, it offers a unique opportunity to contribute to innovative research that could enhance recovery for future patients.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.

What prior data suggests that telephone-based physical activity coaching is safe for older adults undergoing lung cancer surgery?

Research has shown that phone-based physical activity coaching is safe for older adults recovering from lung cancer surgery. Studies have found this type of coaching manageable and free of major issues. For instance, one study on phone coaching for older patients after surgery found it practical and safe. Participants did not report any major problems during or after the sessions.

Overall, evidence suggests that phone-based exercise coaching is a safe choice for those seeking to improve their physical abilities after surgery. Participants have generally responded well to the coaching, with no serious negative events reported. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about the Physical Activity Coaching for Lung Cancer trial because it explores a new way to support lung cancer patients through personalized physical activity programs. Unlike traditional treatments that primarily focus on surgery, chemotherapy, or radiation, this approach emphasizes the potential benefits of exercise tailored to individual needs. The trial includes telephone-based coaching, which helps patients and their family caregivers set fitness goals and provides ongoing support, making physical activity a more integral part of recovery and survivorship. This method aims to improve quality of life and potentially enhance recovery outcomes by incorporating regular, personalized exercise into the patient's routine.

What evidence suggests that this trial's treatments could be effective for improving physical function in older adults undergoing lung cancer surgery?

Research has shown that phone-based coaching, which participants in this trial may receive, can help older adults stay active and improve their physical abilities after lung cancer surgery. Studies have found that this type of coaching boosts recovery and enhances quality of life. In this trial, patients receiving phone coaching will set fitness goals and follow a personalized activity plan. This method provides easy support and guidance, potentially leading to better results. Overall, phone coaching may help maintain or even improve physical abilities during the challenging time around surgery. ^{1 5 6 7 8}

Who Is on the Research Team?

Dan Raz

Principal Investigator

City of Hope Medical Center

Are You a Good Fit for This Trial?

This trial is for older adults scheduled for lung cancer surgery and their caregivers. It aims to see if phone coaching or self-monitoring can help maintain physical function during this time. Participants should be able to perform basic exercises and have access to a telephone.

Inclusion Criteria

Agreement to wear pedometer during study duration

I am 65 years old or older.

I can read and understand English or Spanish and am willing to complete surveys about my health.

Exclusion Criteria

My lung surgery is scheduled within the next 2 weeks.

Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including exercise program and compliance issues related to feasibility/logistics)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Pre-Surgery Coaching

Patients attend telephone-based coaching sessions 7-14 days before surgery

1-2 weeks

1 session (virtual)

Post-Surgery Coaching

Patients attend telephone-based coaching sessions at days 7, 14, 21, and 51 post-discharge

8 weeks

4 sessions (virtual)

Follow-up

Participants are monitored for functional capacity and quality of life at 30, 60, and 180 days post-discharge

6 months

What Are the Treatments Tested in This Trial?

Interventions

• Self Monitored Physical Activity
• Telephone-based Physical Activity Coaching

Trial Overview The study tests two methods: one where participants receive regular phone calls from a coach who guides them through physical activities, and another where they monitor their own exercise routine without guidance.

How Is the Trial Designed?

Group I: Arm I (Telephone-based coaching session) Experimental Treatment 6 Interventions

Patients attend telephone-based coaching sessions over 20-50 minutes once 7-14 days before standard of care surgery, and then at days 7, 14, 21, and 51 post-discharge, for a total of 5 sessions. Patients also receive a personalized physical activity program and set fitness goals. FCGs also receive coaching and serve as a walking buddy for their patient. Patients and FCGs also wear an activity monitor throughout the trial.

Group II: Arm II (Written education) Active Control 5 Interventions

Patients receive written educational materials on physical activity and cancer survivorship. Patients and FCGs also wear an activity monitor throughout the trial.

Who Is Running the Clinical Trial?

City of Hope Medical Center

Lead Sponsor

Trials

614

Recruited

1,924,000+

National Cancer Institute (NCI)

Collaborator

Trials

14,080

Recruited

41,180,000+

Published Research Related to This Trial

A 12-week tele-coaching intervention for lung transplant recipients was found to be feasible and well-accepted, with 86% of participants enjoying the program and no adverse events reported.

Participants in the tele-coaching group significantly increased their daily steps and movement intensity compared to the usual care group, indicating that this intervention can effectively enhance physical activity levels post-lung transplantation.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Feasibility and acceptability of a physical activity behavioural modification tele-coaching intervention in lung transplant recipients. Hume, E., Muse, H., Wallace, K., et al.[2022]

This study will assess the effectiveness of a 12-week home-based exercise and self-management program for lung cancer patients post-surgery, comparing it to usual care in a randomized controlled trial with 112 participants.

The primary outcome is improvement in physical function, measured by the EORTC QLQ c30 questionnaire, with secondary outcomes including health-related quality of life and exercise capacity, evaluated over 12 months.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effect of a postoperative home-based exercise and self-management programme on physical function in people with lung cancer (CAPACITY): protocol for a randomised controlled trial. Granger, CL., Edbrooke, L., Antippa, P., et al.[2022]

In a study of 34 patients who underwent lung resection, those who received accelerometer-based exercise instruction significantly increased their daily steps to an average of 8039 steps compared to 4887 steps in the control group two months post-surgery.

The intervention group also showed greater improvements in light intensity physical activity (LPA) and moderate-vigorous intensity physical activity (MVPA), indicating that accelerometer-based guidance effectively enhances physical activity levels after lung surgery.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The effectiveness of an accelerometer-based physical activity enhancement intervention for patients undergoing lung resection - A pilot randomized controlled trial. Sunahara, M., Matsuzawa, R., Nakagawa, F., et al.[2023]

Preoperative exercise-based interventions significantly improve pulmonary function in lung cancer patients before lung resection surgery, with standardized mean differences indicating meaningful enhancements.

Patients who participated in these exercise programs experienced shorter hospital stays and a reduced risk of postoperative complications, highlighting the intervention's potential to improve recovery outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Functional and postoperative outcomes after preoperative exercise training in patients with lung cancer: a systematic review and meta-analysis. Sebio Garcia, R., Yáñez Brage, MI., Giménez Moolhuyzen, E., et al.[2022]

The physical activity self-management program for lung cancer patients was feasible, with a high consent rate of 89% and an average of 4 consultations per participant, primarily initiated post-surgery.

While the program did not significantly increase physical activity levels or reduce sedentary time after 8 weeks, it helped maintain activity levels compared to typical declines reported in other studies, suggesting potential benefits that warrant further investigation in a randomized controlled trial.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

CAPACITY: A physical activity self-management program for patients undergoing surgery for lung cancer, a phase I feasibility study. Granger, CL., Irving, L., Antippa, P., et al.[2019]

Postoperative exercise interventions for surgical lung cancer patients have high to moderate-quality evidence showing they can significantly improve exercise capacity and muscle strength, which are crucial for recovery.

Preoperative exercise interventions may also enhance exercise capacity and pulmonary function, reduce the risk of postoperative complications, and shorten hospital stays, although the evidence quality is lower.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Effects of perioperative exercise interventions on lung cancer patients: An overview of systematic reviews. Zhou, W., Woo, S., Larson, JL.[2021]

A study of 23 operable non-small cell lung cancer patients showed that physical activity levels decreased after surgery but improved significantly by six months post-operation, nearly returning to preoperative levels.

Increased moderate-to-vigorous physical activity in the first month after surgery was linked to better health outcomes at six months, including improved walking distance, quality of life, and reduced fatigue, highlighting the importance of early postoperative activity.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Physical behavior and associations with health outcomes in operable NSCLC patients: A prospective study. Timmerman, JGJ., Dekker-van Weering, MGHM., Wouters, MWJMM., et al.[2019]

Only 23-28% of surgical lung cancer patients met the recommended physical activity guidelines of 150 minutes per week, indicating a significant gap in pre- and post-operative physical activity levels.

Physical activity levels decreased after surgery, with patients averaging fewer daily steps (3934-8863) in the first 1-3 months post-surgery compared to preoperative levels, suggesting a need for interventions to enhance recovery and improve health outcomes.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Physical activity in surgical lung cancer patients: a systematic review. Zhou, W., Webster, KE., Smith, EL., et al.[2022]

Citations

1. clinicaltrials.gov clinicaltrials.gov/study/NCT06196008

Study Details | NCT06196008 | Telephone-based Physical ... Telephone-based physical activity coaching may improve physical functioning for older adults with lung cancer who are undergoing surgery. Detailed Description.

2. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/39118035/

design of a multicenter pragmatic randomized trial - PubMed The primary aim of this comparative effectiveness trial is to determine whether telephone-based physical activity coaching before and after ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S1556086425021495

P3.18.84 A Randomized Comparative Effectiveness Trial of ... P3.18.84 A Randomized Comparative Effectiveness Trial of Perioperative Physical Activity in Older Adults With Lung Cancer and Their Family Caregivers.

4. bmccancer.biomedcentral.com bmccancer.biomedcentral.com/articles/10.1186/s12885-024-12660-5

Comparative effectiveness of perioperative physical activity in ... The trial will determine whether this telephone-based physical activity coaching approach can enhance postoperative functional capacity and QOL outcomes.

5. clinicaltrials.stanford.edu clinicaltrials.stanford.edu/trials/t/NCT06196008.html

Telephone-based Physical Activity Coaching or Self ... Telephone-based physical activity coaching may improve physical functioning for older adults with lung cancer who are undergoing surgery. Official Title. SR2204 ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8805142/

Pilot Study of a Telehealth Perioperative Physical Activity ... In this study, we assessed the feasibility of a personalized telehealth intervention to enhance physical activity for older (≥65 years) gastrointestinal (GI) ...

7. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC12427458/

Physical Activity Telecoaching in Post-Surgical NSCLC ... These results demonstrate that telecoaching is feasible, acceptable, and safe in patients recovering from lung cancer surgery and may offer an ...

8. clinicaltrials.gov clinicaltrials.gov/study/NCT06057766

Physical Activity Coaching After Surgery for Patients with ... The goal of this randomized controlled clinical trial is to test a 12-week physical activity telecoaching program for NSCLC patients after surgery.