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Procedure

Weight Loss Surgery for Fatty Liver Disease

N/A

Waitlist Available

Research Sponsored by Washington University School of Medicine

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up before and after ~20% weightloss, up to 6 months

Awards & highlights

Study Summary

This trial will look at how weight loss affects the rates of liver scarring in obese patients.

Who is the study for?

This trial is for individuals with obesity, specifically those who have a body mass index (BMI) of 35 kg/m2 or higher and are scheduled for weight loss surgery. It's not open to pregnant individuals, people with liver diseases other than NAFLD, those who've had bariatric surgery before, anyone with significant organ dysfunction/disease, tobacco users, or heavy alcohol drinkers.Check my eligibility

What is being tested?

The study is looking at how effective significant weight loss from bariatric surgery can be on improving liver health in people with non-alcoholic fatty liver disease (NAFLD). The focus is on the rate of hepatic fibrogenesis reduction post-surgery.See study design

What are the potential side effects?

While the trial itself doesn't list specific side effects related to the intervention since it focuses on surgical outcomes rather than medication side effects, potential risks generally associated with weight loss surgery include nutritional deficiencies, digestive issues and surgical complications.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ before and after ~20% weightloss, up to 6 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~before and after ~20% weightloss, up to 6 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and before and after ~20% weightloss, up to 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Hepatic Fibrogenesis

Liver histology

Secondary outcome measures

Adipose histology

Body composition

Insulin sensitivity

+12 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Weight lossExperimental Treatment1 Intervention

Participants will undergo weight loss surgery

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Weight loss surgery

2008

N/A

~80

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Washington University School of MedicineLead Sponsor

1,931 Previous Clinical Trials

2,299,679 Total Patients Enrolled

5 Trials studying Non-alcoholic Fatty Liver Disease

284 Patients Enrolled for Non-alcoholic Fatty Liver Disease

Media Library

Weight loss surgery (Procedure) Clinical Trial Eligibility Overview. Trial Name: NCT03701828 — N/A

Non-alcoholic Fatty Liver Disease Research Study Groups: Weight loss

Non-alcoholic Fatty Liver Disease Clinical Trial 2023: Weight loss surgery Highlights & Side Effects. Trial Name: NCT03701828 — N/A

Weight loss surgery (Procedure) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03701828 — N/A

Non-alcoholic Fatty Liver Disease Patient Testimony for trial: Trial Name: NCT03701828 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are participants of this experiment over the age of forty permissible?

"This medical trial is open to patients within the age range of 18-65. Additionally, there are 33 studies for those under legal age and 319 trials that cater to individuals over 65 years old."

Answered by AI

Can I join this medical experiment?

"This trial is actively seeking 30 people aged 18 to 65 suffering from fatty liver. Crucially, they need to possess a body mass index of at least 35 kg/m2 and have an upcoming bariatric surgery scheduled."

Answered by AI

What is the end goal of this investigation?

"This medical trial will measure the liver histology of participants before and after a 20% weight loss, over a 6 month period. Secondary outcomes include examining tissue gene expression (mRNA content), lipidomics in adipose, liver and blood tissues, as well as protein synthesis rates within plasma proteins."

Answered by AI

Has this clinical trial opened enrollment to participants yet?

"Affirmative. Per the information available on clinicaltrials.gov, this medical study is currently recruiting participants. It was initially posted on February 1st 2019 and most recently updated on August 22nd 2022. 30 individuals must be enlisted from a single centre for the trial to go ahead as planned."

Answered by AI

How many individuals have volunteered to partake in this clinical exploration?

"Affirmative. According to the information accessible on clinicaltrials.gov, this study is actively seeking out volunteers for participation. The trial was originally posted in February 2019 and amended as recently as August 2022; 30 people are needed from 1 site."

Answered by AI

Who else is applying?

What state do they live in?

Missouri

What site did they apply to?

Washington University School of Medicine

What portion of applicants met pre-screening criteria?

Met criteria

How many prior treatments have patients received?

Why did patients apply to this trial?

I need to lose weight. I’ve tried many things to lose weight and keep it off. Over the years since childhood I have gone up and down. Since menopause I have stayed obese. On a recent ultrasound it showed fatty liver disease. Would like to reverse the trend.

PatientReceived no prior treatments

Recent research and studies

clinicaltrials.govStudy

Liver Health and Metabolic Function in People With Obesity

2019. "Liver Health and Metabolic Function in People With Obesity". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03701828.

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