Weight Loss Surgery for Fatty Liver Disease
Trial Summary
What is the purpose of this trial?
This trial is studying if losing a lot of weight can help reduce liver scarring in people with obesity who have a common liver disease called NAFLD. The goal is to see if weight loss can prevent severe liver problems.
Eligibility Criteria
This trial is for individuals with obesity, specifically those who have a body mass index (BMI) of 35 kg/m2 or higher and are scheduled for weight loss surgery. It's not open to pregnant individuals, people with liver diseases other than NAFLD, those who've had bariatric surgery before, anyone with significant organ dysfunction/disease, tobacco users, or heavy alcohol drinkers.Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Pre-surgery Assessment
Participants undergo various assessments including genotyping, body composition, and insulin sensitivity before weight loss surgery
Weight Loss Surgery
Participants undergo weight loss surgery to achieve significant weight loss
Post-surgery Follow-up
Participants are monitored for changes in liver fibrogenesis, lipid turnover, and other metabolic functions after weight loss
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Weight loss surgery
Find a Clinic Near You
Who Is Running the Clinical Trial?
Washington University School of Medicine
Lead Sponsor