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Glycemic Management for High Blood Sugar in Surgical Patients

N/A
Waitlist Available
Research Sponsored by University of Calgary
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Undergoing a surgical procedure, adults (older than 18 years of age), admitted to the hospital for more than 24 hours after their surgical procedure.
Be older than 18 years old
Must not have
Under 18 years of age
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 weeks after the index surgical procedure
Awards & highlights
No Placebo-Only Group

Summary

This trial tests a special care plan called PGMP to manage blood sugar in surgical patients at risk of high levels. It aims to improve recovery by monitoring and controlling blood sugar, reducing complications, and shortening hospital stays.

Who is the study for?
This trial is for adults over 18 who are undergoing surgery and will be in the hospital for more than a day afterward. It's designed to help those at risk of high blood sugar after their operation, including people with known or undiagnosed diabetes.
What is being tested?
The trial tests a Perioperative Glycemic Management Pathway (PGMP) against usual care to see if it can better manage post-surgery blood sugar levels, shorten hospital stays, reduce readmissions, and save costs. The study involves multiple hospitals and uses a stepped-wedge design.
What are the potential side effects?
Since this intervention focuses on managing blood sugar levels around the time of surgery rather than medication side effects per se, specific side effects aren't listed but may include risks associated with any changes in glycemic control.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am an adult who will be in the hospital for more than a day after surgery.

Exclusion Criteria

You may be eligible for the trial if you check “No” for criteria below:
Select...
I am under 18 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~365 days after surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and 365 days after surgery for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Length of stay
Secondary study objectives
Hypoglycemia
Readmissions
Other study objectives
Surgical site infections

Awards & Highlights

No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.

Trial Design

2Treatment groups
Active Control
Group I: Intervention: PGMPActive Control1 Intervention
Sites will implement a perioperative glycemic management pathway based on national guidelines and current evidence, with support of an implementation scientist team.
Group II: Non-intervention: usual careActive Control1 Intervention
Sites will perform usual perioperative glycemic management.

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
Common treatments for high blood sugar include insulin therapy and GLP-1 receptor agonists. Insulin therapy lowers blood glucose by promoting cellular glucose uptake and reducing hepatic glucose production. GLP-1 receptor agonists enhance meal-induced insulin secretion, inhibit glucagon release, and slow gastric emptying. These mechanisms are vital for high blood sugar patients, particularly in perioperative settings, to prevent complications like infections, extended hospital stays, and increased mortality.
Protocol for a prospective, international cohort study on the Management and Outcomes of Perioperative Care among European Diabetic Patients (MOPED).Diabetes and cardiovascular disease: from new mechanisms to new therapies.Perioperative Glycemic Management of Patients Undergoing Bariatric Surgery.

Find a Location

Who is running the clinical trial?

University of CalgaryLead Sponsor
809 Previous Clinical Trials
876,814 Total Patients Enrolled

Media Library

Perioperative glycemic management pathway Clinical Trial Eligibility Overview. Trial Name: NCT05036655 — N/A
High Blood Sugar Research Study Groups: Intervention: PGMP, Non-intervention: usual care
High Blood Sugar Clinical Trial 2023: Perioperative glycemic management pathway Highlights & Side Effects. Trial Name: NCT05036655 — N/A
Perioperative glycemic management pathway 2023 Treatment Timeline for Medical Study. Trial Name: NCT05036655 — N/A
~2353 spots leftby Dec 2025