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Urolithin A for Healthy Subjects

N/A

Recruiting

Led By Josephine M Egan, M.D.

Research Sponsored by National Institute on Aging (NIA)

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Ability to take oral medication and be willing to adhere to the daily regimen

Male or female, age >= 55 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 8 weeks

Awards & highlights

Study Summary

"This trial will test if a natural supplement called Urolithin A (UA) can help improve how the body controls blood glucose levels in people aged 55 and older with a BMI of 27

Who is the study for?

This trial is for healthy adults aged 55 or older with a body mass index (BMI) of 27 or higher. Participants will be involved in the study for about 8 weeks, which includes taking gelcaps daily and undergoing various tests such as blood draws after drinking a sweet liquid, wearing a glucose monitor, exercising on a treadmill, and having imaging scans.Check my eligibility

What is being tested?

The trial is testing whether Urolithin A (UA), taken as gelcaps every morning, can improve insulin levels and help control blood sugar compared to a placebo. Half of the participants will receive UA while the other half will get a placebo that looks identical but contains no medicine.See study design

What are the potential side effects?

Potential side effects are not explicitly mentioned in the provided information. However, since Urolithin A is being tested for its effects on glucose metabolism in healthy adults, any unexpected changes in blood sugar levels or reactions to the supplement would be monitored.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can take pills and will follow the daily medication schedule.

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I am 55 years old or older.

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I can walk and use a treadmill without any physical problems.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 8 weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~8 weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

To determine if urolithin A supplementation will influence insulin secretion in response to oral glucose at 4 and 8 weeks after supplementation.

Secondary outcome measures

To determine if UA supplementation will alter gut microbiome composition.

To determine if UA supplementation will enhance mitochondria respiration, based on p31 spectroscopy by thigh MRI/MRS at baseline and 8 weeks after supplementation.

To determine if UA supplementation will increase incretin secretion in response to oral glucose at 4 and 8 weeks after the supplementation.

+1 more

Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Urolithin AActive Control1 Intervention

50% of participants

Group II: PlaceboPlacebo Group1 Intervention

50% of participants

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

National Institute on Aging (NIA)Lead Sponsor

1,675 Previous Clinical Trials

28,020,705 Total Patients Enrolled

Josephine M Egan, M.D.Principal InvestigatorNational Institute on Aging (NIA)

12 Previous Clinical Trials

17,760 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Which specific individuals are considered the ideal candidates for inclusion in this clinical trial?

"To be eligible for participation, individuals should be in good health and fall within the age range of 55 to 100 years. The study aims to recruit a total of 180 participants."

Answered by AI

Are potential participants currently able to apply for enrollment in this trial?

"The current data on clinicaltrials.gov indicates that this particular research endeavor is no longer in need of additional participants. Originally uploaded on February 28, 2024, and last revised on February 22, 2024, the study has concluded its recruitment phase. Nonetheless, there are a substantial number of 812 other trials actively seeking new participants at present."

Answered by AI

Are individuals aged 75 and above eligible to enroll in this research study?

"Patients aged between 55 and a centenary are eligible for participation in this study. There are 66 ongoing trials catering to minors under 18 years old, and an additional 384 targeting individuals surpassing the age of consent."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial

2024. "Effects of Urolithin A Supplementation on Glucose Metabolism in Healthy Adults 55 >= Years Old: A Randomized Triple-Masked Controlled Clinical Trial". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT06274749.

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