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HIIT for Reducing Frailty in Older Veterans (HIIT@Home Trial)

Led By Bruce R. Troen, MD
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Screening 3 weeks
Treatment Varies
Follow Up change from baseline to endpoint at 12 weeks
Awards & highlights


This trial is studying how high intensity exercise can help older people stay physically active and healthy as they age.

Who is the study for?
This trial is for older veterans, both male and female of any race, who are at least 60 years old. Participants should be non-frail or pre-frail with a frailty score less than 3 and must be medically cleared to exercise. Those with severe COPD, advanced kidney disease, extreme high blood pressure, or significant cognitive impairment cannot join.Check my eligibility
What is being tested?
The study is testing the effects of different types of High Intensity Interval Training (HIIT) on reducing frailty and enhancing resilience in older adults. It compares center-based HIIT, home-based HIIT against a control group receiving standard attention without intensive training.See study design
What are the potential side effects?
While specific side effects are not listed for this type of physical intervention, general risks may include muscle soreness, fatigue after workouts, increased risk of falls during exercise sessions and potential exacerbation of underlying health conditions.


Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~change from baseline to endpoint at 12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and change from baseline to endpoint at 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Body Composition (Lean and fat mass)
C-Reactive Protein
Frailty assessment
+8 more
Secondary outcome measures
Amyloid beta 42/40 ratio
Anxiety and depression
Brain Derived Neurotrophic Factor (BDNF)
+10 more

Trial Design

3Treatment groups
Experimental Treatment
Group I: Home based HIITExperimental Treatment1 Intervention
Home based HIIT
Group II: Center based attention controlExperimental Treatment1 Intervention
Center based attention control
Group III: Center based HIITExperimental Treatment1 Intervention
Center based HIIT

Research Highlights

Information in this section is not a recommendation. We encourage patients to speak with their healthcare team when evaluating any treatment decision.
Mechanism Of Action
Side Effect Profile
Prior Approvals
Other Research
High Intensity Interval Training (HIIT) improves frailty by enhancing muscle strength, endurance, and mitochondrial function, while reducing inflammation. These mechanisms are crucial for frailty patients as they lead to better physical performance and functional capacity, allowing for improved recovery from stressors. This enhanced resilience helps maintain optimal health and reduces the risk of adverse outcomes such as falls, hospitalization, and mortality.
High Intensity Interval Training Improves Physical Performance and Frailty in Aged Mice.Are the group-based interventions improving the functional exercise capacity and quality of life of frail subjects with chronic heart failure?Short Session High Intensity Interval Training and Treadmill Assessment in Aged Mice.

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Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,628 Previous Clinical Trials
3,325,779 Total Patients Enrolled
10 Trials studying Frailty
40,664 Patients Enrolled for Frailty
Bruce R. Troen, MDPrincipal InvestigatorKansas City VA Medical Center, Kansas City, MO
2 Previous Clinical Trials
78 Total Patients Enrolled
2 Trials studying Frailty
78 Patients Enrolled for Frailty

Media Library

Center based HIIT Clinical Trial Eligibility Overview. Trial Name: NCT05625204 — N/A
Frailty Research Study Groups: Center based attention control, Center based HIIT, Home based HIIT
Frailty Clinical Trial 2023: Center based HIIT Highlights & Side Effects. Trial Name: NCT05625204 — N/A
Center based HIIT 2023 Treatment Timeline for Medical Study. Trial Name: NCT05625204 — N/A
~133 spots leftby Dec 2027